AXL signaling pathway (Homo sapiens)

From WikiPathways

Revision as of 07:26, 17 March 2020 by Keshav (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
PLASMA MEMBRANELEF1CCND1VEGFAMYCBECN1NLRP3ZEB1AXIN2CASP1MAP1LC3BANXA2FN1TGFBR2ATG52450MSNTGF4GLI2CALD1TGFB2TMEM132ASMOADAM11GLI3NRG1TGFB1I1SPARCBMP8BAKT3SNAI3MITFAHNAK2VAV11PBMP6EGFRY1101BMP716, 23Y1173CDK427SP1CAV210CDK627CD274MYC CXCL16TGFB1TMEFF1LINC00526CXCR6BMP8ALYNGLI1 RPS6KA1BCL2T35929S363BIRC5FOXP3TGFB2COL3A1CHEK129LIGHTTFTGFBR2P53CCR2YESDKK3SERPINE1CCL2ADGRE1VIMAXLY815Y86041, 44, 51Y779SOCS1ACOX1NFKB147MKI67CTLA4GSK3 5, 15, 20, 31S9STAT141PBCL2L1TGFB1MAPK8P2, 30, 42RAC140RPS6S253S928, 33S263MMP9CCND1CPT1AATF2P30TNFANGPT2CASP39CTNNB1S552CD36CCNE1 MEK1SOCS3MERTKP25CDKN2AVCAM-1PI3K6, 11, 49PMAP2K221, 40MAP2K121MAPK3T2023, 33, 37MAPK14P24Bcl-2mTOR22PTWISTKDR46IRS-1VEGFA46SNAI1ACTA2CTNNB1JUN30PPDK1LTBCAV1TNS2Y48332CHUKP7, 35BIRC5MAPK92, 30PTIMP1AKT1T308S47318, 25, 26SLUGcell migration and invasionPARP1MAPK1Y20417, 29, 34MET38ACTA1FOXO136PIL1BFOXO1RPS6KB1GAS645PTK219PCOL1A1PAK139PSNAI2SCDELMO151NFKB1P7CDKN1APTPN1146PSNAILMCP1COL1A1CYR61 KRASAutophagyPPARGCYNUAnti-apoptotic Signaling Cell migrationTumor progressionEMTMMP2Tumor invasion/migrationAngiogenesisThrombosisCellular senescenceRegulatory T cells(Tregs)Lung adenocarcinomasCHEK129S280MDM4S31427MDM2MDM4DAPKS3084CIP2A4ProliferationPMEGFR nuclear translocation mediatorsDormacy cellsurvivalApoptosisCYTOPLASMNUCLEUSCDH1Cell survivalRELA25RELAS5299, 13Colorectal CancerTranscription factorsTranscriptional regulator Bone morphogenetic proteinsChemokinesTransmembrane proteinCollagen Osteosarcoma Matrix metalloproteasesRAC12SRCY41614, 43, 48SMAD32S213Liver Inflammation, Steatohepatitis, and FibrosisIL1BIL-18InflammationCTNNB18EGFRPRKACACYNUFASFLT1COL3A1LEGENDLigandReceptorLeads to unknown mechanismPositive regulation of gene expressionNegative regulation of gene expressionTranslocationInhibitionPlasma membraneCytoplasmNucleusPMCPNUInduced CatalysisS100A10 SOCS3SOCS1 Immune suppression


Description

Axl is a transmembrane protein comes under TAM (Tyro3,Axl and Mertk) family of receptor tyrosine kinase (RTK). It is first identified as transforming gene, isolated from primary human myeloid leukemia cells. Axl gene is located in chromosome 19, at 19q13.1 , which encodes 894 amino acids with molecular weight range between 100 and 140kDa. Axl receptor is having extracellular, transmembrane and an intracellular domain. Extra cellular domain contains two immunoglobulin like (IgL) and fibronectin type-III (FN III) like domain with a single pass transmembrane domain. An intracellular protein tyrosine kinase domain contains total six phosphorylation sites, among them three phosphorylation sites were found in N-terminal domain such as Tyr 779 , Tyr 821 and Tyr 866 and other three sites were found in C-terminal domain such as Tyr 698 , Tyr 702 , Tyr 703 which are getting autophosphorlyated to accomplish their complete functions of subsequent kinase activity. Axl activation is mediated by a ligand growth arrest-specific protein 6 (Gas6). The activation of Axl can also occur through ligand independent in response to ROS which mainly occurs during oxidative stress and overexpression of Axl. Axl receptor is extensively expressed in various tissues such as brain, heart, liver, bone marrow, neurons and vascular tissues. The aberrant expression as well as prolonged activation of Axl has been reported in various disease conditions such as cancer, chronic immune disorders and cardiovascular diseases. The Axl receptor is a class of protein that transfer signals from the extracellular matrix into the cytoplasm and results in various signaling pathways through its downstream substrates. This regulates various physiological processes including cell proliferation, survival, motility, aggregation and anti-inflammation. The Axl receptor activation contributes various down signaling pathways including PI3K/AKT, MAPK/ERK, JAK/STAT, and PI3K/AKT/mTOR. Axl ligand independent activation also induces AKT and MAPK signaling pathways and regulates EMT, which are mainly involved in cell proliferation, migration and survival of colorectal cancer. However, it has a major concern in biomedical importance, comprehensive detail about Axl mediated signaling pathway is still unavailable in the publically available pathway resources. Therefore, we systematically developed an integrated pathway map of Axl signaling. The pathway map was developed through literature mining from published literature data based on manual annotation guidelines adapted from Netpath (curated resource of signal transduction pathways in humans). In the present study, PubMed search using query terms showed about 1170 articles, which were related to Axl signaling pathway until November 2019. These articles were carefully reviewed based on our annotation criteria and short listed into 171 articles which had information pertinent to Axl mediated signaling.

Comments

 
March_2020
 
Type your comment here

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Ammoun S, Provenzano L, Zhou L, Barczyk M, Evans K, Hilton DA, Hafizi S, Hanemann CO; ''Axl/Gas6/NF-kappa-B signalling in schwannoma pathological proliferation, adhesion and survival.''; Oncogene, 2014 PubMed Europe PMC Scholia
  2. Elkabets M, Pazarentzos E, Juric D, Sheng Q, Pelossof RA, Brook S, Benzaken AO, Rodon J, Morse N, Yan JJ, Liu M, Das R, Chen Y, Tam A, Wang H, Liang J, Gurski JM, Kerr DA, Rosell R, Teixid C, Huang A, Ghossein RA, Rosen N, Bivona TG, Scaltriti M, Baselga J; ''AXL mediates resistance to PI3K inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.''; Cancer Cell, 2015 PubMed Europe PMC Scholia
  3. Bertin FR, Lemari CA, Robins RS, Blostein MD; ''Growth arrest-specific 6 regulates thrombin-induced expression of vascular cell adhesion molecule-1 through forkhead box O1 in endothelial cells.''; J Thromb Haemost, 2015 PubMed Europe PMC Scholia
  4. Hasanbasic I, Cuerquis J, Varnum B, Blostein MD; ''Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells.''; Am J Physiol Heart Circ Physiol, 2004 PubMed Europe PMC Scholia
  5. Ruan GX, Kazlauskas A; ''Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  6. Grommes C, Lee CY, Wilkinson BL, Jiang Q, Koenigsknecht-Talboo JL, Varnum B, Landreth GE; ''Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases.''; J Neuroimmune Pharmacol, 2008 PubMed Europe PMC Scholia
  7. Shankar SL, O'Guin K, Kim M, Varnum B, Lemke G, Brosnan CF, Shafit-Zagardo B; ''Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  8. Yu H, Liu R, Ma B, Li X, Yen HY, Zhou Y, Krasnoperov V, Xia Z, Zhang X, Bove AM, Buscarini M, Parekh D, Gill IS, Liao Q, Tretiakova M, Quinn D, Zhao J, Gill PS; ''Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma.''; Br J Cancer, 2015 PubMed Europe PMC Scholia
  9. Li W, Xiong X, Abdalla A, Alejo S, Zhu L, Lu F, Sun H; ''HGF-induced formation of the MET-AXL-ELMO2-DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion.''; J Biol Chem, 2018 PubMed Europe PMC Scholia
  10. Collina F, La Sala L, Liotti F, Prevete N, La Mantia E, Chiofalo MG, Aquino G, Arenare L, Cantile M, Liguori G, Di Gennaro F, Pezzullo L, Losito NS, Vecchio G, Botti G, Melillo RM, Franco R; ''AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer.''; Cancers (Basel), 2019 PubMed Europe PMC Scholia
  11. Antony J, Tan TZ, Kelly Z, Low J, Choolani M, Recchi C, Gabra H, Thiery JP, Huang RY; ''The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.''; Sci Signal, 2016 PubMed Europe PMC Scholia
  12. Martinelli E, Martini G, Cardone C, Troiani T, Liguori G, Vitagliano D, Napolitano S, Morgillo F, Rinaldi B, Melillo RM, Liotti F, Nappi A, Bianco R, Berrino L, Ciuffreda LP, Ciardiello D, Iaffaioli V, Botti G, Ferraiolo F, Ciardiello F; ''AXL is an oncotarget in human colorectal cancer.''; Oncotarget, 2015 PubMed Europe PMC Scholia
  13. Wang C, Jin H, Wang N, Fan S, Wang Y, Zhang Y, Wei L, Tao X, Gu D, Zhao F, Fang J, Yao M, Qin W; ''Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3-catenin Signaling.''; Theranostics, 2016 PubMed Europe PMC Scholia
  14. Goudarzi S, Rivera A, Butt AM, Hafizi S; ''Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination.''; ASN Neuro, 2016 PubMed Europe PMC Scholia
  15. Allen MP, Xu M, Linseman DA, Pawlowski JE, Bokoch GM, Heidenreich KA, Wierman ME; ''Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  16. Chen YL, Tsai YT, Chao TT, Wu YN, Chen MC, Lin YH, Liao CH, Chou SP, Chiang HS; ''DAPK and CIP2A are involved in GAS6/AXL-mediated Schwann cell proliferation in a rat model of bilateral cavernous nerve injury.''; Oncotarget, 2018 PubMed Europe PMC Scholia
  17. Gallicchio M, Mitola S, Valdembri D, Fantozzi R, Varnum B, Avanzi GC, Bussolino F; ''Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor.''; Blood, 2005 PubMed Europe PMC Scholia
  18. Jin Y, Nie D, Li J, Du X, Lu Y, Li Y, Liu C, Zhou J, Pan J; ''Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing -Catenin.''; Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  19. Brand TM, Iida M, Corrigan KL, Braverman CM, Coan JP, Flanigan BG, Stein AP, Salgia R, Rolff J, Kimple RJ, Wheeler DL; ''The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor.''; Sci Signal, 2017 PubMed Europe PMC Scholia
  20. Paccez JD, Duncan K, Vava A, Correa RG, Libermann TA, Parker MI, Zerbini LF; ''Inactivation of GSK3B pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma.''; Mol Biol Cell, 2015 PubMed Europe PMC Scholia
  21. Ammoun S, Provenzano L, Zhou L, Barczyk M, Evans K, Hilton DA, Hafizi S, Hanemann CO; ''Axl/Gas6/NFB signalling in schwannoma pathological proliferation, adhesion and survival.''; Oncogene, 2014 PubMed Europe PMC Scholia
  22. Goruppi S, Chiaruttini C, Ruaro ME, Varnum B, Schneider C; ''Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells.''; Mol Cell Biol, 2001 PubMed Europe PMC Scholia
  23. Jin CW, Wang H, Chen YQ, Tang MX, Fan GQ, Wang ZH, Li L, Zhang Y, Zhang W, Zhong M; ''Gas6 delays senescence in vascular smooth muscle cells through the PI3K/ Akt/FoxO signaling pathway.''; Cell Physiol Biochem, 2015 PubMed Europe PMC Scholia
  24. Yumoto K, Eber MR, Wang J, Cackowski FC, Decker AM, Lee E, Nobre AR, Aguirre-Ghiso JA, Jung Y, Taichman RS; ''Axl is required for TGF-2-induced dormancy of prostate cancer cells in the bone marrow.''; Sci Rep, 2016 PubMed Europe PMC Scholia
  25. Song X, Wang H, Logsdon CD, Rashid A, Fleming JB, Abbruzzese JL, Gomez HF, Evans DB; ''Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma.''; Cancer, 2011 PubMed Europe PMC Scholia
  26. Baumann C, Ullrich A, Torka R; ''GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance.''; Mol Oncol, 2017 PubMed Europe PMC Scholia
  27. Paccez JD, Vasques GJ, Correa RG, Vasconcellos JF, Duncan K, Gu X, Bhasin M, Libermann TA, Zerbini LF; ''The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.''; Oncogene, 2013 PubMed Europe PMC Scholia
  28. Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW; ''Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.''; Oncogene, 2008 PubMed Europe PMC Scholia
  29. Li Y, Jia L, Liu C, Gong Y, Ren D, Wang N, Zhang X, Zhao Y; ''Axl as a downstream effector of TGF-1 via PI3K/Akt-PAK1 signaling pathway promotes tumor invasion and chemoresistance in breast carcinoma.''; Tumour Biol, 2015 PubMed Europe PMC Scholia
  30. Heidemann D; ''[The speedomatic amalgam condensation instrument set. Clinical experiences].''; Quintessenz, 1983 PubMed Europe PMC Scholia
  31. Yanagita M, Ishii K, Ozaki H, Arai H, Nakano T, Ohashi K, Mizuno K, Kita T, Doi T; ''Mechanism of inhibitory effect of warfarin on mesangial cell proliferation.''; J Am Soc Nephrol, 1999 PubMed Europe PMC Scholia
  32. Ben-Batalla I, Schultze A, Wroblewski M, Erdmann R, Heuser M, Waizenegger JS, Riecken K, Binder M, Schewe D, Sawall S, Witzke V, Cubas-Cordova M, Janning M, Wellbrock J, Fehse B, Hagel C, Krauter J, Ganser A, Lorens JB, Fiedler W, Carmeliet P, Pantel K, Bokemeyer C, Loges S; ''Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma.''; Blood, 2013 PubMed Europe PMC Scholia
  33. Brcena C, Stefanovic M, Tutusaus A, Joannas L, Menndez A, Garca-Ruiz C, Sancho-Bru P, Mar­ M, Caballeria J, Rothlin CV, Fernndez-Checa JC, de Frutos PG, Morales A; ''Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.''; J Hepatol, 2015 PubMed Europe PMC Scholia
  34. de Polo A, Luo Z, Gerarduzzi C, Chen X, Little JB, Yuan ZM; ''AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex.''; J Mol Cell Biol, 2017 PubMed Europe PMC Scholia
  35. Gomes AM, Carron EC, Mills KL, Dow AM, Gray Z, Fecca CR, Lakey MA, Carmeliet P, Kittrell F, Medina D, Machado HL; ''Stromal Gas6 promotes the progression of premalignant mammary cells.''; Oncogene, 2019 PubMed Europe PMC Scholia
  36. Lee EH, Kim EM, Ji KY, Park AR, Choi HR, Lee HY, Kim SM, Chung BY, Park CH, Choi HJ, Ko YH, Bai HW, Kang HS; ''Axl acts as a tumor suppressor by regulating LIGHT expression in T lymphoma.''; Oncotarget, 2017 PubMed Europe PMC Scholia
  37. Brown JE, Krodel M, Pazos M, Lai C, Prieto AL; ''Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.''; PLoS One, 2012 PubMed Europe PMC Scholia
  38. Wu G, McBride DW, Zhang JH; ''Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-B pathway after MCAO in rats.''; Neurobiol Dis, 2018 PubMed Europe PMC Scholia
  39. Han J, Bae J, Choi CY, Choi SP, Kang HS, Jo EK, Park J, Lee YS, Moon HS, Park CG, Lee MS, Chun T; ''Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice.''; Autophagy, 2016 PubMed Europe PMC Scholia
  40. Lee Y, Lee M, Kim S; ''Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug.''; Biochem Biophys Res Commun, 2013 PubMed Europe PMC Scholia
  41. Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ; ''Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.''; Proc Natl Acad Sci U S A, 2014 PubMed Europe PMC Scholia
  42. ''''; , PubMed Europe PMC Scholia
  43. Sainaghi PP, Castello L, Bergamasco L, Galletti M, Bellosta P, Avanzi GC; ''Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.''; J Cell Physiol, 2005 PubMed Europe PMC Scholia
  44. Peng CK, Wu CP, Lin JY, Peng SC, Lee CH, Huang KL, Shen CH; ''Gas6/Axl signaling attenuates alveolar inflammation in ischemia-reperfusion-induced acute lung injury by up-regulating SOCS3-mediated pathway.''; PLoS One, 2019 PubMed Europe PMC Scholia
  45. Allen MP, Zeng C, Schneider K, Xiong X, Meintzer MK, Bellosta P, Basilico C, Varnum B, Heidenreich KA, Wierman ME; ''Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.''; Mol Endocrinol, 1999 PubMed Europe PMC Scholia
  46. Reichl P, Dengler M, van Zijl F, Huber H, Fhrlinger G, Reichel C, Sieghart W, Peck-Radosavljevic M, Grubinger M, Mikulits W; ''Axl activates autocrine transforming growth factor- signaling in hepatocellular carcinoma.''; Hepatology, 2015 PubMed Europe PMC Scholia
  47. Demarchi F, Verardo R, Varnum B, Brancolini C, Schneider C; ''Gas6 anti-apoptotic signaling requires NF-kappa B activation.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  48. Cheng LC, Chen YL, Cheng AN, Lee AY, Cho CY, Huang JS, Chuang SE; ''AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells.''; J Biomed Sci, 2018 PubMed Europe PMC Scholia
  49. Sen T, Tong P, Diao L, Li L, Fan Y, Hoff J, Heymach JV, Wang J, Byers LA; ''Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer.''; Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  50. Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW; ''Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.''; Oncogene, 2008 PubMed Europe PMC Scholia
  51. Leconet W, Larbouret C, Chard T, Thomas G, Neiveyans M, Busson M, Jarlier M, Radosevic-Robin N, Pugnire M, Bernex F, Penault-Llorca F, Pasquet JM, Plegrin A, Robert B; ''Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy.''; Oncogene, 2014 PubMed Europe PMC Scholia
  52. Wang C, Jin H, Wang N, Fan S, Wang Y, Zhang Y, Wei L, Tao X, Gu D, Zhao F, Fang J, Yao M, Qin W; ''Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3-catenin Signaling.''; Theranostics, 2016 PubMed Europe PMC Scholia
  53. Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, C JF; ''Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.''; Mol Cell Biol, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
111812view18:27, 8 September 2020EgonwRemoved a space in a PubMed identifier.
111809view16:01, 8 September 2020EgonwRemoved semicolons from the PubMed identifiers
111785view14:01, 7 September 2020DeSlRemoved special characters in publication list.
111784view13:52, 7 September 2020DeSlUpdated PMID ID (removed semicolon).
111783view13:51, 7 September 2020DeSlUpdated SRC protein ID
111515view05:07, 24 August 2020Rex D A Bupdate
111146view06:44, 20 July 2020Rex D A Blegend updated
111142view03:27, 19 July 2020Rex D A B
111141view03:25, 19 July 2020Rex D A BConnections
111140view13:18, 18 July 2020KeshavModified description
111138view11:14, 17 July 2020Rex D A BConnections and protein name
109999view19:17, 11 April 2020KeshavOntology Term : 'Gas6 - Axl signaling axis' added !
109998view19:11, 11 April 2020Keshavinteractions
109917view16:59, 6 April 2020KhanspersOntology Term : 'signaling pathway' added !
109422view07:26, 17 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Matrix metalloproteases
Immune suppression
RPS6KA1ProteinNP_002944.2 (NCBI Protein)
ACOX1GeneProduct51 (Entrez Gene)
ACTA1GeneProduct58 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
ADAM11GeneProduct4185 (Entrez Gene)
ADGRE1GeneProductADGRE1
AHNAK2GeneProduct113146 (Entrez Gene)
AKT1GeneProductAKT1 (Other)
AKT3GeneProduct10000 (Entrez Gene)
ANGPT2GeneProduct285 (Entrez Gene)
ANXA2GeneProductANXA2
ATF2ProteinNP_001871.2 (NCBI Protein)
ATG5GeneProduct9474 (Entrez Gene)
AXIN2GeneProductAXIN2
AXLProteinNP_068713.2 (NCBI Protein)
Angiogenesis
Anti-apoptotic Signaling
Apoptosis
Autophagy
BCL2GeneProduct596 (Entrez Gene)
BCL2L1GeneProduct596 (Entrez Gene)
BECN1GeneProduct8678 (Entrez Gene)
BIRC5GeneProductBIRC5
BMP6GeneProduct654 (Entrez Gene)
BMP7GeneProduct655 (Entrez Gene)
BMP8AGeneProduct353500 (Entrez Gene)
BMP8BGeneProduct656 (Entrez Gene)
Bcl-2GeneProductBcl-2
Bone morphogenetic proteins
CALD1GeneProduct800 (Entrez Gene)
CASP1GeneProductCASP1
CASP3GeneProduct836 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene)
CAV2GeneProduct858 (Entrez Gene)
CCL2GeneProduct6347 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND1GeneProductCCND1
CCNE1 GeneProductCCNE1
CCR2GeneProduct729230 (Entrez Gene)
CD274GeneProduct29126 (Entrez Gene)
CD36GeneProduct948 (Entrez Gene)
CDH1GeneProductCDH1
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CHEK1Protein1111 (Entrez Gene)
CHEK1ProteinCHEK1 (NCBI Protein)
CHUKProteinNP_001269.3 (NCBI Protein)
CIP2AGeneProduct57650 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
CPT1AGeneProduct1374 (Entrez Gene)
CTLA4GeneProduct12477 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNB1GeneProductCTNNB1
CXCL16GeneProduct58191 (Entrez Gene)
CXCR6GeneProduct10663 (Entrez Gene)
CY
CYR61 GeneProduct3491 (Entrez Gene)
Cell migration
Cell survival
Cellular senescence
Chemokines
Collagen
Colorectal Cancer
DAPKGeneProduct1612 (Entrez Gene)
DKK3GeneProduct27122 (Entrez Gene)
Dormacy cellsurvival
EGFR nuclear translocation mediators
EGFRGeneProductEGFR
EGFRGeneProductEGFR (Other)
ELMO1GeneProduct9844 (Entrez Gene)
EMT
FASGeneProductFAS
FLT1GeneProduct2321 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO1ProteinNP_002006.2 (NCBI Protein)
FOXP3GeneProduct50943 (Entrez Gene)
GAS6GeneProduct2621 (Entrez Gene)
GLI1GeneProduct2735 (Entrez Gene)
GLI2GeneProduct2736 (Entrez Gene)
GLI3GeneProduct2737 (Entrez Gene)
GSK3 ProteinNP_002084.2 (NCBI Protein)
IL-18GeneProduct3606 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IRS-1GeneProduct3667 (Entrez Gene)
Inflammation
JUNProteinNP_002219.1 (NCBI Protein)
KDRGeneProduct3791 (Entrez Gene)
KRASGeneProductKRAS
LEF1GeneProduct51176 (Entrez Gene)
LIGHTGeneProduct8740 (Entrez Gene)
LINC00526GeneProduct147525 (Entrez Gene)
LTBGeneProduct4050 (Entrez Gene)
LYNGeneProductLYN
Liver Inflammation, Steatohepatitis, and Fibrosis
Lung adenocarcinomas
MAP1LC3BGeneProduct81631 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14ProteinNP_001306.1 (NCBI Protein)
MAPK1ProteinNP_002736.3 (NCBI Protein)
MAPK3ProteinNP_002737.2 (NCBI Protein)
MAPK8ProteinNP_001310259.1 (NCBI Protein)
MAPK9ProteinNP_002743.3 (NCBI Protein)
MCP1GeneProductMCP1
MDM2GeneProductMDM2
MDM4GeneProductMDM4
MDM4ProteinNP_002384.2 (NCBI Protein)
MEK1GeneProductMEK1
MERTKProteinNP_006334.2 (NCBI Protein)
METGeneProduct4233 (Entrez Gene)
MITFGeneProduct4286 (Entrez Gene)
MKI67GeneProductMKI67
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
MSNGeneProduct4478 (Entrez Gene)
MYC GeneProduct4609 (Entrez Gene)
MYCGeneProductMYC
NFKB1GeneProduct4790 (Entrez Gene)
NFKB1ProteinNP_065390.1 (NCBI Protein)
NLRP3GeneProduct114548 (Entrez Gene)
NRG1GeneProduct3084 (Entrez Gene)
NU
Osteosarcoma
P53GeneProductP53
PAK1ProteinNP_002567.3 (NCBI Protein)
PARP1GeneProduct142 (Entrez Gene)
PDK1GeneProductPDK1
PI3KProteinNP_006209.2 (NCBI Protein)
PM
PPARGGeneProduct5468 (Entrez Gene)
PRKACA5566 (Entrez Gene)
PTK2ProteinNP_001186578.1 (NCBI Protein)
PTPN11ProteinNP_002825.3 (NCBI Protein)
Proliferation
RAC1GeneProduct5879 (Entrez Gene)
RACProteinNP_008839.2 (NCBI Protein)
RELAGeneProduct5970 (Entrez Gene)
RELAProteinNP_065390.1 (NCBI Protein)
RPS6KB1ProteinNP_003152.1 (NCBI Protein)
RPS6ProteinNP_001001.2 (NCBI Protein)
Regulatory T cells (Tregs)
S100A10 GeneProductS100A10
SCDGeneProduct6319 (Entrez Gene)
SERPINE1GeneProductSERPINE1
SLUGGeneProductSLUG
SMAD3ProteinNP_005893.1 (NCBI Protein)
SMOGeneProduct6608 (Entrez Gene)
SNAI1GeneProduct6615 (Entrez Gene)
SNAI2GeneProduct6591 (Entrez Gene)
SNAI3GeneProduct333929 (Entrez Gene)
SNAILGeneProductSNAIL
SOCS1GeneProduct8651 (Entrez Gene)
SOCS1GeneProductSOCS1
SOCS3GeneProduct9021 (Entrez Gene)
SOCS3GeneProductSOCS3
SP1GeneProduct28423548 (Entrez Gene)
SPARCGeneProduct6678 (Entrez Gene)
SRCProteinNP_005408.1 (NCBI Protein)
STAT1ProteinNP_009330.1 (NCBI Protein)
TFGeneProductTF
TGF4GeneProduct6925 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB1I1GeneProduct7041 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TMEFF1GeneProduct8577 (Entrez Gene)
TMEM132AGeneProduct54972 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNS2ProteinNP_056134.2 (NCBI Protein)
TWISTGeneProduct7291 (Entrez Gene)
Thrombosis
Transcription factors
Transcriptional regulator
Transmembrane protein
Tumor invasion/migration
Tumor progression
VAV1ProteinNP_005419.2 (NCBI Protein)
VCAM-1GeneProduct7412 (Entrez Gene)
VEGFAGeneProduct7422 (Entrez Gene)
VIMGeneProduct7431 (Entrez Gene)
YESGeneProductYES
ZEB1GeneProduct6935 (Entrez Gene)
cell migration and invasion
mTORProteinNP_004949.1 (NCBI Protein)

Annotated Interactions

No annotated interactions
Personal tools