Peroxiredoxin 2 induced ovarian failure (Mus musculus)

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1The number of follicles and Corpora lutea declinesOvarian functional degenerationOvarian failureAgingOvarian structural degenerationApoptosisSize of ovaries declineReactive oxygen species StAR CYP11A1BaxPeroxiredoxin-2Cytochrome cPARPProgesteroneCaspase-3JNK3Beta-HSDEstradiol-17beta


This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.

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Ontology Terms



  1. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS; ''Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.''; Free Radic Biol Med, 2018 PubMed Europe PMC Scholia


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110293view14:20, 2 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110230view14:26, 27 April 2020EgonwUpdated the data source.
110070view08:45, 16 April 2020FehrhartOntology Term : 'c-Jun N-terminal kinases MAPK signaling pathway' added !
110069view08:45, 16 April 2020FehrhartAdded reference and some graphical adjustments
110068view08:43, 16 April 2020FehrhartModified description
109438view12:54, 17 March 2020FehrhartOntology Term : 'ovarian dysfunction' added !
109437view12:54, 17 March 2020FehrhartOntology Term : 'signaling pathway' added !
109250view11:56, 2 March 2020LaurentModified title
109233view12:10, 1 March 2020Bas LahaijeNew pathway

External references


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NameTypeDatabase referenceComment
3Beta-HSDProteinE9PXG7 (Uniprot-TrEMBL)
BaxGeneProductENSMUSG00000003873 (Ensembl)
CYP11A1ProteinQ9QZ82 (Uniprot-TrEMBL) Mitochondrial
Caspase-3ProteinA0A1B0GRX1 (Uniprot-TrEMBL)
Cytochrome cProteinP62897 (Uniprot-TrEMBL) Somatic
Estradiol-17betaMetaboliteCHEBI:4864 (ChEBI)
JNKProteinENSMUSP00000023291 (Ensembl Mouse)
PARPMetaboliteCHEBI:62913 (ChEBI)
Peroxiredoxin-2ProteinQ61171 (Uniprot-TrEMBL)
ProgesteroneMetaboliteCHEBI:45786 (ChEBI)
Reactive oxygen species MetaboliteCHEBI:26523 (ChEBI)
StAR ProteinP51557 (Uniprot-TrEMBL)
  • Mitichondrial
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Annotated Interactions

No annotated interactions

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