Peroxiredoxin 2 induced ovarian failure (Mus musculus)

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Ovarian structural degenerationAgingThe number of follicles and Corpora lutea declinesApoptosisSize of ovaries declineOvarian failureOvarian functional degenerationReactive oxygen species Estradiol-17beta3Beta-HSDStAR BaxProgesteroneCaspase-3JNKPARPCytochrome cPeroxiredoxin-2CYP11A1


Description

This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.

Quality Tags

Ontology Terms

 

Bibliography

  1. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS; ''Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.''; Free Radic Biol Med, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110293view14:20, 2 May 2020EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
110230view14:26, 27 April 2020EgonwUpdated the data source.
110070view08:45, 16 April 2020FehrhartOntology Term : 'c-Jun N-terminal kinases MAPK signaling pathway' added !
110069view08:45, 16 April 2020FehrhartAdded reference and some graphical adjustments
110068view08:43, 16 April 2020FehrhartModified description
109438view12:54, 17 March 2020FehrhartOntology Term : 'ovarian dysfunction' added !
109437view12:54, 17 March 2020FehrhartOntology Term : 'signaling pathway' added !
109250view11:56, 2 March 2020LaurentModified title
109233view12:10, 1 March 2020Bas LahaijeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3Beta-HSDProteinE9PXG7 (Uniprot-TrEMBL)
BaxGeneProductENSMUSG00000003873 (Ensembl)
CYP11A1ProteinQ9QZ82 (Uniprot-TrEMBL) Mitochondrial
Caspase-3ProteinA0A1B0GRX1 (Uniprot-TrEMBL)
Cytochrome cProteinP62897 (Uniprot-TrEMBL) Somatic
Estradiol-17betaMetaboliteCHEBI:4864 (ChEBI)
JNKProteinENSMUSP00000023291 (Ensembl Mouse)
PARPMetaboliteCHEBI:62913 (ChEBI)
Peroxiredoxin-2ProteinQ61171 (Uniprot-TrEMBL)
ProgesteroneMetaboliteCHEBI:45786 (ChEBI)
Reactive oxygen species MetaboliteCHEBI:26523 (ChEBI)
StAR ProteinP51557 (Uniprot-TrEMBL)
  • Mitichondrial
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Annotated Interactions

No annotated interactions

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