GDNF/RET signalling axis (Mus musculus)

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Revision as of 13:32, 18 February 2020 by S. Arnouts (Talk | contribs)
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Metanephric mesenchymeNephric ductRepulsionNephrogenic cordMaintenanceSALL1SOX11GFRA1LIM1RETGLI3RFOXC2PAX2SPRY1IFT27GREM1FOXC1BMP4SLIT2IFT25EYA1ROBO2FAT4β-catGATA3GDNFSOX17AGTR2GDNF


Description

GDNF-RET signalling is at the core of the signalling network in kidney development. These signalling interactions between the metanephric mesenchyme and the nephric duct are crucial to ensure the induction of the ureter from the nephric duct.

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Ontology Terms

 

Bibliography

  1. Kozlov VM, Schedl A; ''Duplex kidney formation: developmental mechanisms and genetic predisposition.''; F1000Res, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
109222view07:40, 28 February 2020FehrhartFixed connections
109221view07:37, 28 February 2020FehrhartAdded reference
109220view07:34, 28 February 2020FehrhartUpdated version
109145view13:32, 18 February 2020S. ArnoutsOntology Term : 'CAKUT' added !
109144view13:31, 18 February 2020S. ArnoutsOntology Term : 'regulatory pathway' added !
109143view13:29, 18 February 2020S. ArnoutsModified description
109142view13:28, 18 February 2020S. ArnoutsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AGTR2GeneProductENSMUSG00000068122 (Ensembl)
BMP4GeneProductENSMUSG00000021835 (Ensembl)
EYA1GeneProductENSMUSG00000025932 (Ensembl)
FAT4GeneProductENSMUSG00000046743 (Ensembl)
FOXC1GeneProductENSMUSG00000050295 (Ensembl)
FOXC2GeneProductENSMUSG00000046714 (Ensembl)
GATA3GeneProductENSMUSG00000015619 (Ensembl)
GDNFGeneProductENSMUSG00000022144 (Ensembl)
GFRA1ProteinP97785 (Uniprot-TrEMBL)
GLI3RProteinQ61602 (Uniprot-TrEMBL)
GREM1GeneProductENSMUSG00000074934 (Ensembl)
IFT25ProteinQ9D6H2 (Uniprot-TrEMBL)
IFT27ProteinQ9D0P8 (Uniprot-TrEMBL)
LIM1GeneProductENSMUSG00000018698 (Ensembl)
PAX2GeneProductENSMUSG00000004231 (Ensembl)
RETProteinP35546 (Uniprot-TrEMBL)
ROBO2GeneProductENSMUSG00000052516 (Ensembl)
SALL1GeneProductENSMUSG00000031665 (Ensembl)
SLIT2GeneProductENSMUSG00000031558 (Ensembl)
SOX11GeneProductENSMUSG00000063632 (Ensembl)
SOX17GeneProductENSMUSG00000025902 (Ensembl)
SPRY1GeneProductENSMUSG00000037211 (Ensembl)
β-catProteinQ02248 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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