FGFR3 signalling in chondrocyte proliferation and terminal differentiation (Homo sapiens)

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1Endochondral ossificationWntPre-hypertrophic chondrocytesproduced by prehypertrophicand hypertrophic chondrocytes AutophagyReserve chondrocytesPerichondrium/periosteumChondrocyte differentiationHypertrophic chondrocytesNPR2MAPK13FGFR33,3',5'-TriiodothyronineFGF9BMP2STAT1PTHLHCNPSNAI1IHHATG5THRAMAPK11MAPK12FGF18MAPK14PTH1RPTH1RProliferating chondrocytesBMP4OMIM:215045Chondrodysplasia,Blomstrand typeOMIM:600002Eiken syndromeOMIM:156400Metaphyseal chondrodysplasia,Murk Jansen typeOMIM:187600Thanatophoric dysplasia, type IOMIM:187601Thanatophoric dysplasia, type IIOMIM:616482SADDANOMIM:100800AchondroplasiaOMIM:146000HypochondroplasiaOMIM:610474CATSHL syndromeOMIM:613382Brachydactyly, type E2OMIM:612961Multiple synostoses syndrome 3OMIM:607778Acrocapitofemoral dysplasiaOMIM:112600Brachydactyly, type A2OMIM:602875Acromesomelic dysplasia, Maroteaux typeSOX9RBL1CDKN1ARBL1PPPPPPP2CAChondrocyte proliferationOMIM:612247Crouzon syndrome withacanthosis nigricansOMIM:602849Muenke syndromeOMIM:149730LADD syndromeOMIM:215045Chondrodysplasia,Blomstrand typeOMIM:600002Eiken syndromeOMIM:156400Metaphyseal chondrodysplasia,Murk Jansen typeOMIM:615923Epiphyseal chondrodysplasia, Miura typeOMIM:112500Brachydactyly, type A1Syndactyly Lueken type


Description

No description

Quality Tags

Ontology Terms

 

Bibliography

  1. Ornitz DM, Legeai-Mallet L; ''Achondroplasia: Development, pathogenesis, and therapy.''; Dev Dyn, 2017 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
109131view06:31, 18 February 2020RleeFixed unconnected line.
108991view00:07, 13 February 2020Khanspersdecreased BoardHeight
108990view00:07, 13 February 2020Khanspersdecreased BoardHeight
108989view00:06, 13 February 2020Khanspersdecreased BoardHeight and BoardWidth
108988view00:05, 13 February 2020Khanspersdecreased BoardHeight
108768view01:56, 29 January 2020RleeRemoved extra DataNode
108767view01:54, 29 January 2020RleeModified description
108766view01:53, 29 January 2020RleeAdded ERK1/2 branch of MAPK pathway
108739view10:56, 27 January 2020DeSlModified description
108738view10:56, 27 January 2020DeSlOntology Term : 'parathyroid hormone signaling pathway' added !
108737view10:55, 27 January 2020DeSlOntology Term : 'thyroid hormone signaling pathway' added !
108736view10:54, 27 January 2020DeSlOntology Term : 'fibroblast growth factor signaling pathway' added !
108735view10:53, 27 January 2020DeSlOntology Term : 'Muenke Syndrome' added !
108734view10:48, 27 January 2020DeSlModified description
108733view10:36, 27 January 2020DeSlModified description
108732view10:33, 27 January 2020DeSlConverted arrows to graphical lines for disease connectivity.
108643view23:09, 14 January 2020RleeFixed unconnected line.
108622view23:44, 12 January 2020RleeModified description
108621view23:40, 12 January 2020RleeModified title
108620view23:40, 12 January 2020RleeNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3,3',5'-TriiodothyronineMetaboliteCHEBI:11684 (ChEBI)
ATG5GeneProductENSG00000057663 (Ensembl)
BMP2GeneProductENSG00000125845 (Ensembl)
BMP4GeneProductENSG00000125378 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CNPGeneProductENSG00000173786 (Ensembl)
FGF18GeneProductENSG00000156427 (Ensembl)
FGF9GeneProductENSG00000102678 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
IHHGeneProductENSG00000163501 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
NPR2GeneProductENSG00000159899 (Ensembl)
PPP2CAGeneProductENSG00000113575 (Ensembl)
PTH1RGeneProductENSG00000160801 (Ensembl)
PTHLHGeneProductENSG00000087494 (Ensembl)
RBL1GeneProductENSG00000080839 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SOX9GeneProductENSG00000125398 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
THRAGeneProductENSG00000126351 (Ensembl)

Annotated Interactions

No annotated interactions

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