FGFR3 signalling in chondrocyte proliferation and terminal differentiation (Homo sapiens)

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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="FGFR3 signalling in chondrocyte proliferation and terminal differentiation" Version="20191218" Organism="Homo sapiens">
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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="FGFR3 signalling in chondrocyte proliferation and terminal differentiation" Version="20191218" Organism="Homo sapiens"><Comment Source="WikiPathways-description">Taken from Achondroplasia: Development, Pathenogenesis, and Therapy by Ornitz DM, Legeai-Mallet L (www.ncbi.nlm.nih.gov/pubmed/27987249)
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Signaling pathways in the postnatal growth plate.
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During endochondral bone development, FGF9 and FGF18, derived from the perichondrium and surrounding tissue, signal to FGFR3 in chondrocytes. The balance of chondrocyte proliferation and differentiation is controlled by crosstalk of several signaling pathways. Expression of FGFR3 is enhanced by thyroid hormone (T3/3,3',5'-Triiodothyronine) and suppressed by PTHLH. FGFR3 signaling results in increased expression of Snail1 (encoded by SNAI1), which is required for activation of STAT1 and MAPK signaling (p38 branches). Signaling from PTHLH, IHH and BMPs antagonizes the suppression of chondrocyte proliferation by FGFR3. Both FGFR3 and PTHLH function to suppress chondrocyte differentiation and antagonize the action of Wnt signaling, which promotes differentiation. FGFR3 negatively regulates the autophagy protein, ATG5. Activation of downstream signals: PP2a (encoded by PPP2CA) regulates p107 (encoded by RBL1) activation, and STAT1 regulates p21Waf1/Cip1 (encoded by CKDN1A) activation. Both function to suppress chondrocyte proliferation. Activation of the MAPKs, ERK1, and ERK2, regulate Sox9 expression, which functions to suppress chondrocyte terminal differentiation and endochondral ossification.
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Linked with a dotted arrow to the GeneProduct nodes are diseases caused by mutation in the respective gene.</Comment>
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   <BiopaxRef>e9a</BiopaxRef>
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Revision as of 23:44, 12 January 2020

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

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CompareRevisionActionTimeUserComment
108739view10:56, 27 January 2020DeSlModified description
108738view10:56, 27 January 2020DeSlOntology Term : 'parathyroid hormone signaling pathway' added !
108737view10:55, 27 January 2020DeSlOntology Term : 'thyroid hormone signaling pathway' added !
108736view10:54, 27 January 2020DeSlOntology Term : 'fibroblast growth factor signaling pathway' added !
108735view10:53, 27 January 2020DeSlOntology Term : 'Muenke Syndrome' added !
108734view10:48, 27 January 2020DeSlModified description
108733view10:36, 27 January 2020DeSlModified description
108732view10:33, 27 January 2020DeSlConverted arrows to graphical lines for disease connectivity.
108643view23:09, 14 January 2020RleeFixed unconnected line.
108622view23:44, 12 January 2020RleeModified description
108621view23:40, 12 January 2020RleeModified title
108620view23:40, 12 January 2020RleeNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/1/14/WP4767_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/1/14/WP4767_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 108622)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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