Acetylcholine Synthesis (Danio rerio)

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1Synaptic CleftPyruvate from GlycolysisCytosolAcetyl-CoApemtpcyt1aaachechkapdha2chatpdha1aAcetateCholineAcetylcholine Choline Glycerophosphocholine Posphatidylcholines Posphatidylethanolamines Cytidine diphosphate cholinePhosphorylcholine


Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.

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Ontology Terms



  1. Blusztajn JK, Wurtman RJ; ''Choline and cholinergic neurons.''; Science, 1983 PubMed Europe PMC Scholia


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109425view08:02, 17 March 2020L DupuisDeleted a line that wasn't connected to anything
104305view17:05, 15 May 2019EgonwReplaced a secondary ChEBI ID with primary ID.
104302view14:03, 15 May 2019Fehrhartconnected lines
104301view14:01, 15 May 2019Fehrhartadded metabolite ID
104300view13:59, 15 May 2019Fehrhartadded metabolite Ids
77433view12:17, 8 September 2014Mkutmonupdated some gene labels and layout.
77400view22:33, 5 September 2014MaintBotremoved homology mapp label
71503view19:21, 17 October 2013MaintBotAutomated update of data sources
71017view19:48, 22 September 2013EgonwAdded identifiers for a number of metabolites.
70058view07:15, 12 July 2013Mkutmonhomology mapp was overwriting pathway title
70057view07:13, 12 July 2013Mkutmonfixed unconnected lines, changed labels to metabolites
70056view07:09, 12 July 2013MkutmonPeriodical save, work in progress
68621view04:08, 6 July 2013MaintBotUpdated to 2013 gpml schema
67028view09:56, 26 June 2013Christine ChichesterOntology Term : 'acetylcholine metabolic pathway' added !
40784view22:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35067view11:22, 11 February 2010ThomasModified description
35065view11:16, 11 February 2010Thomasadded literature reference
34175view21:19, 9 December 2009MaintBotAutomatic update of empty xrefs
21682view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:Acetylcholine Synthesis]] moved to [[Pathway:WP476]]: Moved to stable identifier
12036view08:45, 15 May 2008MaintBotAdded to category $category
12034view08:45, 15 May 2008A.KwaUploaded new pathway

External references


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NameTypeDatabase referenceComment
Acetate MetaboliteCHEBI:30089 (ChEBI)
Acetyl-CoAMetaboliteCHEBI:57288 (ChEBI)
Acetylcholine MetaboliteCHEBI:15355 (ChEBI)
Choline MetaboliteCHEBI:15354 (ChEBI)
Choline MetaboliteCHEBI:15354 (ChEBI)
Cytidine diphosphate cholineMetaboliteCHEBI:16436 (ChEBI)
Glycerophosphocholine MetaboliteCHEBI:36313 (ChEBI)
PhosphorylcholineMetaboliteCHEBI:18132 (ChEBI)
Posphatidylcholines MetaboliteCHEBI:49183 (ChEBI)
Posphatidylethanolamines MetaboliteCHEBI:16038 (ChEBI)
acheGeneProduct114549 (Entrez Gene)
chatGeneProduct100170938 (Entrez Gene)
chkaGeneProductENSDARG00000041078 (Ensembl)
pcyt1aaGeneProduct550327 (Entrez Gene)
pdha1aGeneProduct406702 (Entrez Gene)
pemtGeneProduct393127 (Entrez Gene)

Annotated Interactions

No annotated interactions

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