IL-18 signaling pathway (Homo sapiens)

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CYNUIRAK1P1IL-18 Signaling PathwayCYCSTRAF6IL18RAPIL18BAXIL18R1MAPK1Y204IL-18BPProteinProtein - protein dissociationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation Induced catalysisProtein-protein interactionLEGENDPhosphorylationGolgi apparatusEndosomeNucleusMitochondrionCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageProteinmRNALigandEnzyme complexCASP8NOX1TICAM2SLC12A3LCKPCYMTCYCSCYMTNFKB1NCF1NCF2NCF1NCF2CYPMIMP3ELAVL1CTNNB1GSK3BCYNUCCL2CCL3CCL4IL18R1IL18RAPIL18BPIFNGMMP3MMP8MMP14MMP13MMP9MMP2LTBIL13TIMP3TIMP1PTX3IER3TP53MYH6IL17RCIL18TRPM7DEKFOXN3PRCCHSPB8CCL5BTG2TNIP3CCL1TMEM165BIN1TSHZ1MBTPS1PTPN7PHF20TRPC2MTCH1HPS1SLC4A7AARSUCK1ZNF219NSMFKCNH2PPP1R13LPLOD3MEPCEARFGAP2RASA3TRPC4APPTMSEEF2ProteinInduced activationInterleukinsChemokinesMatrix metalloproteases CytokinesCDsTNF familyGrowth factorsTight-junctionproteinsTranscriptionfactorsCell cycleregulatorsOxidativestressMetabolic enzymesTransport proteinsNFKB familyUncategorizedCell deathregulatorsStructural proteinsOthersHormonesPhosphatasesKinasesDeacetylases and UbiquitinasesProtein-modifying enzymesTRAF1FASFADDTNFSF11TNFRSF11BTNFAIP2TNFAIP3TNFFASLGCLDN12CLDN4CLDN3CLDN1CLDN15Signaling proteinsProteinsynthesisJUNRUNX2FOSIRF6KLF2BIRC3BADBCL2BCL2L1PTENPTPRZ1CCNB2CCNA2CDK5R2mRNAsplicingPLA2G7NACAEPB41SYT10ZNF444RUSC1CCDC9FAM110AITM2CGRNATF3NFKBIANFKBIERELBNFKB2RELNFKB1RELANFKBIZAKT1T308S473MAPK3T202CREB1S133MAPK14T180Y182PIK3R1PELK1S383MAPK8T183Y185ATF2T71CHUKPIKBKBPRPS6S235S240S244S236SRCY419Y139NFKBIAPHSPB1PCSN2PMAP3K7PGSK3AS21PTENPACACBS79JUNS63S73GRIN2BPPRKCAPPRKCBPRAF1Y360Y361TNFRSF1AMEF2ACEBPBGATA1SP1CFLARBIDCASP3IRF1TNFTP53FASLGFASCYPMMAPK9T180Y182ProteinInduced inhibitionReceptorNUCLEUSCYTOPLASMPLASMAMEMBRANEMITOCHONDRIAMYD88IL1BIL2RAIL10IL12BIL9IL6CCL19CCL20CXCL16CXCL2CXCL3CCL18CXCL8MMP1NR1H3ABHD16ATACR1SDC4RGS16SOCS3EPS8GRM7NR4A1SEMA6DHCAR2SEMA6CARF6RXRBRPTORS1PR4CD36CD83CD81VEGFACCN4BMP2HDGFNOS2LONP2ELAVL1IMP3NFATC4S676NFKB1RELAS536S276CTNNB1GSK3BS9CYNUCYNUCYNUCYNUCYNUNFATC4BSGFN1CNTN2ICAM1SPP1ITGA2BCell adhesionmoleculesRELACOL1A1COL3A1COL1A2DESMYH7ACTA1TMSB4XACTA2SNTB1CRYGCLMNB2KLC1Ion channelsTFCETPRAE1B2MABCF1ARL4DTOMM40RANGAP1PKN1KITLGBAZ1BSTK40HDAC3USP5FBXW7ADIPOQNR0B2NDUFC1ZDHHC7GPAT4HMOX1ENO1UGGT1PYGBLARS2PLCG1APBA2ADAMTS5STOML1ZC3H12AZNF143FAM186BNRN1SPON1STMN1RPS11NPPBNPPAKRT31FUT1CA11ANP32ALRRFIP1NCAPH2ZBTB7ARND2ALS2ARFGAP1PRM1KIFC3PWWP3ACENPBHOXD8BPGMACADSCPT1AHADHPTGS2PPT2ACOD1COX17ECH1TGM2PLD1PIGTUGT2B10ARG1IRAK4MAP2K7STAT3Y705BAXAMPK1T172PARP1RPS6KB1T389IL37ULBP2MYD88RFX5TBX21STAT3CYNUPRKCDPBADS136Promotes Th1 responseActivation of intrinsic and extrinsic proapoptotic signalingImmune process proteinsInduces NK cellsand Th1 responsePro-apoptoticreponseMucosal mast cellinduced Th2 responseMucosal mast cell differentiationMucosal mast cell induced Th2 responseinduces ECM degradation andcardiac remodelingMMP inhibitorsAugments liver cellproliferationInduces inflammatory responseRegulates NK cell activity during Listeria infectionIncreases intestinalhyperpermeabilityand microbial translocationEnhances breast cancer cell migration