Thyroid hormones production and their peripheral downstream signalling effects regarding congenital hypothyroidism (Homo sapiens)

From WikiPathways

(Difference between revisions)
Jump to: navigation, search
(Replaced secondary ChEBI identifiers with a primary identifiers.)
Current revision (08:52, 14 January 2020) (view source)
(changed nodes)
 
Line 180: Line 180:
     <Xref Database="Uniprot-TrEMBL" ID="P16066" />
     <Xref Database="Uniprot-TrEMBL" ID="P16066" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Triidothyronine (T3)" GraphId="a527e" Type="Metabolite">
+
   <DataNode TextLabel="T3" GraphId="a527e" Type="Metabolite">
-
     <Graphics CenterX="655.339556475" CenterY="1051.5780811390052" Width="134.6358543417366" Height="25.0" ZOrder="33246" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="655.3032391590666" CenterY="1051.5780811390052" Width="62.53132767570015" Height="24.99999999999995" ZOrder="33246" FontSize="12" Valign="Middle" Color="0000ff" />
     <Xref Database="ChEBI" ID="CHEBI:18258" />
     <Xref Database="ChEBI" ID="CHEBI:18258" />
   </DataNode>
   </DataNode>
Line 212: Line 212:
     <Xref Database="ChEBI" ID="CHEBI:33569" />
     <Xref Database="ChEBI" ID="CHEBI:33569" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Thyroxine (T4)" GraphId="e2be7" Type="Metabolite">
+
   <DataNode TextLabel="T4" GraphId="e2be7" Type="Metabolite">
-
     <Graphics CenterX="422.84085709999977" CenterY="1051.5780811390055" Width="90.0" Height="25.0" ZOrder="33255" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="422.8408570999997" CenterY="1051.5780811390052" Width="62.531327675700176" Height="25.0" ZOrder="33255" FontSize="12" Valign="Middle" Color="0000ff" />
     <Xref Database="ChEBI" ID="CHEBI:75602" />
     <Xref Database="ChEBI" ID="CHEBI:75602" />
   </DataNode>
   </DataNode>
Line 601: Line 601:
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MCT8" GraphId="ad0f9" Type="Protein">
   <DataNode TextLabel="MCT8" GraphId="ad0f9" Type="Protein">
-
     <Graphics CenterX="655.339556475" CenterY="1091.977583952057" Width="54.078998819968824" Height="25.0" ZOrder="33354" FontSize="12" Valign="Middle" Color="ff0000" />
+
     <Graphics CenterX="655.3032391590664" CenterY="1091.977583952057" Width="54.078998819968824" Height="25.0" ZOrder="33354" FontSize="12" Valign="Middle" Color="ff0000" />
     <Xref Database="Uniprot-TrEMBL" ID="P36021" />
     <Xref Database="Uniprot-TrEMBL" ID="P36021" />
   </DataNode>
   </DataNode>
Line 637: Line 637:
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DIO2" GraphId="c8f85" Type="GeneProduct">
   <DataNode TextLabel="DIO2" GraphId="c8f85" Type="GeneProduct">
-
     <Graphics CenterX="560.8797636624997" CenterY="1030.1347632380955" Width="40.84100999999998" Height="25.0" ZOrder="33374" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="574.5428624741553" CenterY="1030.1347632380955" Width="40.84100999999998" Height="25.0" ZOrder="33374" FontSize="12" Valign="Middle" />
     <Xref Database="Ensembl" ID="ENSG00000211448" />
     <Xref Database="Ensembl" ID="ENSG00000211448" />
   </DataNode>
   </DataNode>
Line 853: Line 853:
     <Graphics ConnectorType="Elbow" ZOrder="32938" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="32938" LineThickness="1.0">
       <Point X="581.4203525918166" Y="991.7093005649623" GraphRef="fef60" RelX="0.0" RelY="1.0" />
       <Point X="581.4203525918166" Y="991.7093005649623" GraphRef="fef60" RelX="0.0" RelY="1.0" />
-
       <Point X="655.339556475" Y="1039.0780811390052" GraphRef="a527e" RelX="0.0" RelY="-1.0" ArrowHead="mim-cleavage" />
+
       <Point X="655.3032391590666" Y="1039.0780811390052" GraphRef="a527e" RelX="0.0" RelY="-1.0" ArrowHead="mim-cleavage" />
     </Graphics>
     </Graphics>
     <Xref Database="" ID="" />
     <Xref Database="" ID="" />
Line 1,003: Line 1,003:
     <BiopaxRef>ddc</BiopaxRef>
     <BiopaxRef>ddc</BiopaxRef>
     <Graphics ZOrder="32957" LineThickness="1.0">
     <Graphics ZOrder="32957" LineThickness="1.0">
-
       <Point X="560.8797636624997" Y="1042.6347632380955" GraphRef="c8f85" RelX="0.0" RelY="1.0" />
+
       <Point X="574.5428624741553" Y="1042.6347632380955" GraphRef="c8f85" RelX="0.0" RelY="1.0" />
-
       <Point X="536.5632749124999" Y="1051.5780811390052" GraphRef="f0d23" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
+
       <Point X="551.2774136228854" Y="1051.5780811390052" GraphRef="f0d23" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
     </Graphics>
     </Graphics>
     <Xref Database="" ID="" />
     <Xref Database="" ID="" />
Line 1,420: Line 1,420:
     <Graphics ConnectorType="Elbow" ZOrder="33009" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="33009" LineThickness="1.0">
       <Point X="581.4203525918166" Y="991.7093005649623" GraphRef="fef60" RelX="0.0" RelY="1.0" />
       <Point X="581.4203525918166" Y="991.7093005649623" GraphRef="fef60" RelX="0.0" RelY="1.0" />
-
       <Point X="422.84085709999977" Y="1039.0780811390055" GraphRef="e2be7" RelX="0.0" RelY="-1.0" ArrowHead="mim-cleavage" />
+
       <Point X="422.84085709999977" Y="1039.0780811390052" GraphRef="e2be7" RelX="0.0" RelY="-1.0" ArrowHead="mim-cleavage" />
     </Graphics>
     </Graphics>
     <Xref Database="" ID="" />
     <Xref Database="" ID="" />
Line 1,594: Line 1,594:
   <Interaction GraphId="b8bcd">
   <Interaction GraphId="b8bcd">
     <Graphics ZOrder="33031" LineThickness="1.0">
     <Graphics ZOrder="33031" LineThickness="1.0">
-
       <Point X="655.339556475" Y="1104.477583952057" GraphRef="ad0f9" RelX="0.0" RelY="1.0" />
+
       <Point X="655.3032391590664" Y="1104.477583952057" GraphRef="ad0f9" RelX="0.0" RelY="1.0" />
       <Point X="655.339556475" Y="1133.218137161414" GraphRef="ac91e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
       <Point X="655.339556475" Y="1133.218137161414" GraphRef="ac91e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
     </Graphics>
     </Graphics>
Line 1,722: Line 1,722:
     <BiopaxRef>b7c</BiopaxRef>
     <BiopaxRef>b7c</BiopaxRef>
     <Graphics ZOrder="33047" LineThickness="1.0">
     <Graphics ZOrder="33047" LineThickness="1.0">
-
       <Point X="655.339556475" Y="1064.0780811390052" GraphRef="a527e" RelX="0.0" RelY="1.0" />
+
       <Point X="655.3032391590666" Y="1064.0780811390052" GraphRef="a527e" RelX="0.0" RelY="1.0" />
-
       <Point X="655.339556475" Y="1079.477583952057" GraphRef="ad0f9" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
+
       <Point X="655.3032391590664" Y="1079.477583952057" GraphRef="ad0f9" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
     </Graphics>
     </Graphics>
     <Xref Database="" ID="" />
     <Xref Database="" ID="" />
Line 1,833: Line 1,833:
     <Graphics ZOrder="33060" LineThickness="1.0">
     <Graphics ZOrder="33060" LineThickness="1.0">
       <Point X="510.97976366249975" Y="1042.6347632380955" GraphRef="aae3f" RelX="0.0" RelY="1.0" />
       <Point X="510.97976366249975" Y="1042.6347632380955" GraphRef="aae3f" RelX="0.0" RelY="1.0" />
-
       <Point X="536.5632749124999" Y="1051.5780811390052" GraphRef="f0d23" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
+
       <Point X="551.2774136228854" Y="1051.5780811390052" GraphRef="f0d23" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
     </Graphics>
     </Graphics>
     <Xref Database="" ID="" />
     <Xref Database="" ID="" />
Line 1,972: Line 1,972:
   <Interaction GraphId="d0b9f">
   <Interaction GraphId="d0b9f">
     <Graphics ZOrder="33078" LineThickness="1.0">
     <Graphics ZOrder="33078" LineThickness="1.0">
-
       <Point X="467.84085709999977" Y="1051.5780811390055" GraphRef="e2be7" RelX="1.0" RelY="0.0" />
+
       <Point X="454.10652093784984" Y="1051.5780811390052" GraphRef="e2be7" RelX="1.0" RelY="0.0" />
-
       <Point X="588.0216293041317" Y="1051.5780811390052" GraphRef="a527e" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
+
       <Point X="624.0375753212165" Y="1051.5780811390052" GraphRef="a527e" RelX="-1.0" RelY="0.0" ArrowHead="mim-conversion" />
       <Anchor Position="0.5718253972921086" Shape="None" GraphId="f0d23" />
       <Anchor Position="0.5718253972921086" Shape="None" GraphId="f0d23" />
     </Graphics>
     </Graphics>
Line 2,138: Line 2,138:
     <BiopaxRef>b7c</BiopaxRef>
     <BiopaxRef>b7c</BiopaxRef>
     <Graphics ZOrder="33098" LineThickness="1.0">
     <Graphics ZOrder="33098" LineThickness="1.0">
-
       <Point X="422.84085709999977" Y="1064.0780811390055" GraphRef="e2be7" RelX="0.0" RelY="1.0" />
+
       <Point X="422.84085709999977" Y="1064.0780811390052" GraphRef="e2be7" RelX="0.0" RelY="1.0" />
       <Point X="422.84085709999977" Y="1079.4775839520573" GraphRef="a1357" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
       <Point X="422.84085709999977" Y="1079.4775839520573" GraphRef="a1357" RelX="0.0" RelY="-1.0" ArrowHead="mim-binding" />
     </Graphics>
     </Graphics>
Line 3,060: Line 3,060:
   <InfoBox CenterX="0.0" CenterY="0.0" />
   <InfoBox CenterX="0.0" CenterY="0.0" />
   <Biopax>
   <Biopax>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e69">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cd1">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15971998</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27681418</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem J</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Rep</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mîinea CP</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Minard AY</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sano H</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tan SX</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kane S</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yang P</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sano E</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fazakerley DJ</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fukuda M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Domanova W</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peränen J</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Parker BL</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lane WS</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Humphrey SJ</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lienhard GE</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jothi R</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stöckli J</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">James DE</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f52">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e8e">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11533250</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18467435</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Biol</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Endocrinology</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
+
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Miller LD</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schakman O</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Park KS</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kalista S</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guo QM</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bertrand L</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alkharouf NW</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lause P</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Malek RL</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verniers J</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee NH</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ketelslegers JM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu ET</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thissen JP</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng SY</bp:AUTHORS>
+
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca5">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21448409</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21448409</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iodine, Iodine metabolism and Iodine deficiency disorders revisited.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Indian J Endocrinol Metab</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ahad F</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ganie SA</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f7c">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25390014</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brown adipose tissue and thermogenesis.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Horm Mol Biol Clin Investig</bp:SOURCE>
 +
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fenzl A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kiefer FW</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a09">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18259611</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Invest</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Simonides WS</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mulcahey MA</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Redout EM</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Muller A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zuidwijk MJ</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Visser TJ</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wassen FW</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Crescenzi A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">da-Silva WS</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Harney J</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Engel FB</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Obregon MJ</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Larsen PR</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bianco AC</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang SA</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e7d">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17666482</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roles of hydrogen peroxide in thyroid physiology and disease.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Endocrinol Metab</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Song Y</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Driessens N</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Costa M</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De Deken X</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Detours V</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Corvilain B</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maenhaut C</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Miot F</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Sande J</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Many MC</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumont JE</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fc4">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fc4">
Line 3,114: Line 3,178:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nikolaev VO</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nikolaev VO</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lohse MJ</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lohse MJ</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf5">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22353746</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DIO2 modifies inflammatory responses in chondrocytes.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Osteoarthritis Cartilage</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng AW</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bolognesi M</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kraus VB</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb9">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21683758</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Endocrinol</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Massart C</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hoste C</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Virion A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ruf J</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumont JE</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Sande J</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a3c">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a3c">
Line 3,123: Line 3,210:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lebeck J</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lebeck J</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a0d">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b42">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20802499</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18329679</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Promotion by thyroid hormone of cytoplasm-to-nucleus shuttling of thyroid hormone receptors.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Med</bp:SOURCE>
+
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Steroids</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Davis PJ</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Davis FB</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lin HY</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eca">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20167242</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Efficient use and recycling of the micronutrient iodide in mammals.</bp:TITLE>
 +
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">López M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rokita SE</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Varela L</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adler JM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vázquez MJ</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McTamney PM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rodríguez-Cuenca S</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watson JA Jr</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">González CR</bp:AUTHORS>
+
    </bp:PublicationXref>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Velagapudi VR</bp:AUTHORS>
+
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a63">
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morgan DA</bp:AUTHORS>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19196800</bp:ID>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schoenmakers E</bp:AUTHORS>
+
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Agassandian K</bp:AUTHORS>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid.</bp:TITLE>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lage R</bp:AUTHORS>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Endocrinology</bp:SOURCE>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Martínez de Morentin PB</bp:AUTHORS>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tovar S</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bizhanova A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nogueiras R</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kopp P</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carling D</bp:AUTHORS>
+
    </bp:PublicationXref>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lelliott C</bp:AUTHORS>
+
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="be4">
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gallego R</bp:AUTHORS>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20051527</bp:ID>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oresic M</bp:AUTHORS>
+
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chatterjee K</bp:AUTHORS>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molecular aspects of thyroid hormone actions.</bp:TITLE>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Saha AK</bp:AUTHORS>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Endocr Rev</bp:SOURCE>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rahmouni K</bp:AUTHORS>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diéguez C</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng SY</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vidal-Puig A</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leonard JL</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Davis PJ</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c2e">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c2e">
Line 3,166: Line 3,264:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gottesman ME</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gottesman ME</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="afe">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b7c">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26207953</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8222576</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thyroid hormone transport proteins.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Endocrinol Metab</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clin Lab Med</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1993</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aguayo-Mazzucato C</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bartalena L</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DiIenno A</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Robbins J</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hollister-Lock J</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cahill C</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sharma A</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Weir G</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Colton C</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bonner-Weir S</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ae0">
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">congenital hypothyroidism</bp:TERM>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21511232</bp:ID>
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0050328</bp:ID>
+
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
+
-
    </bp:openControlledVocabulary>
+
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb1">
+
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17574003</bp:ID>
+
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">New insights into thyroid hormone action.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Inherited defects of thyroid hormone metabolism.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Best Pract Res Clin Endocrinol Metab</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ann Endocrinol (Paris)</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oetting A</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumitrescu AM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yen PM</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Refetoff S</bp:AUTHORS>
-
    </bp:PublicationXref>
+
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">thyroid-stimulating hormone signaling pathway</bp:TERM>
+
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001200</bp:ID>
+
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
+
-
    </bp:openControlledVocabulary>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c77">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27693079</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Transcriptional regulation of the uncoupling protein-1 gene.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Villarroya F</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peyrou M</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giralt M</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e8e">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18467435</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Endocrinology</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schakman O</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kalista S</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bertrand L</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lause P</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verniers J</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ketelslegers JM</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thissen JP</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca5">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21448409</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21448409</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iodine, Iodine metabolism and Iodine deficiency disorders revisited.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Indian J Endocrinol Metab</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ahad F</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ganie SA</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fcf">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fcf">
Line 3,247: Line 3,291:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Targovnik HM</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Targovnik HM</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a79">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ae1">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12172553</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28723567</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Cell Biol</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Inoki K</bp:AUTHORS>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28723567</bp:ID>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li Y</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhu T</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wu J</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guan KL</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b42">
+
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18329679</bp:ID>
+
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Promotion by thyroid hormone of cytoplasm-to-nucleus shuttling of thyroid hormone receptors.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Steroids</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Rep</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Davis PJ</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yao L</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Davis FB</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cui X</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lin HY</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen Q</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yang X</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fang F</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang J</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu G</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jin W</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chang Y</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf5">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b74">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22353746</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22653837</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DIO2 modifies inflammatory responses in chondrocytes.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treatedwith sorafenib.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Osteoarthritis Cartilage</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hepatology</bp:SOURCE>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng AW</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Spirli C</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bolognesi M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morell CM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kraus VB</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Locatelli L</bp:AUTHORS>
-
    </bp:PublicationXref>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Okolicsanyi S</bp:AUTHORS>
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f7c">
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ferrero C</bp:AUTHORS>
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25390014</bp:ID>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim AK</bp:AUTHORS>
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fabris L</bp:AUTHORS>
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brown adipose tissue and thermogenesis.</bp:TITLE>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fiorotto R</bp:AUTHORS>
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Horm Mol Biol Clin Investig</bp:SOURCE>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Strazzabosco M</bp:AUTHORS>
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fenzl A</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kiefer FW</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="be4">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20051527</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molecular aspects of thyroid hormone actions.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Endocr Rev</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng SY</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leonard JL</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Davis PJ</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c13">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c13">
Line 3,312: Line 3,342:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stevenson RE</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stevenson RE</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c93">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eae">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28322461</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17452290</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iodinated TG in Thyroid Follicular Lumen Regulates TTF-1 and PAX8 Expression via TSH/TSHR Signaling Pathway.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Protein kinase C-regulated cAMP response element-binding protein phosphorylation in cultured rat striatal neurons.</bp:TITLE>
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Cell Biochem</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brain Res Bull</bp:SOURCE>
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang H</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shi Y</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liang B</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cai H</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cai Q</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ae0">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21511232</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Inherited defects of thyroid hormone metabolism.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ann Endocrinol (Paris)</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumitrescu AM</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Refetoff S</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e7d">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17666482</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roles of hydrogen peroxide in thyroid physiology and disease.</bp:TITLE>
+
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Endocrinol Metab</bp:SOURCE>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Song Y</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mao LM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Driessens N</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tang Q</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Costa M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang JQ</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De Deken X</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Detours V</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Corvilain B</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maenhaut C</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Miot F</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Sande J</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Many MC</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumont JE</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f06">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f7a">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28235572</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27449104</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADPH: new oxygen for the ROS theory of aging.</bp:TITLE>
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Signal</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oncotarget</bp:SOURCE>
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Houddane A</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bultot L</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Novellasdemunt L</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Johanns M</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gueuning MA</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vertommen D</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Coulie PG</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bartrons R</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hue L</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rider MH</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b47">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24872083</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of adipocyte lipolysis.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nutr Res Rev</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frühbeck G</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Méndez-Giménez L</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernández-Formoso JA</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernández S</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rodríguez A</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c32">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29997323</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Mol Sci</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR>
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29997323</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Mol Sci</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kouidhi S</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clerget-Froidevaux MS</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cd1">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27681418</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.</bp:TITLE>
+
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Rep</bp:SOURCE>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Minard AY</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernandez-Marcos PJ</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tan SX</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nóbrega-Pereira S</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yang P</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fazakerley DJ</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Domanova W</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Parker BL</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Humphrey SJ</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jothi R</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stöckli J</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">James DE</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a63">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bcd">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19196800</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28448947</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Endocrinology</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Redox Biol</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bizhanova A</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Contreras C</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kopp P</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nogueiras R</bp:AUTHORS>
-
    </bp:PublicationXref>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diéguez C</bp:AUTHORS>
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b90">
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rahmouni K</bp:AUTHORS>
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23045339</bp:ID>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">López M</bp:AUTHORS>
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Physiol</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mariotta L</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ramadan T</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Singer D</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guetg A</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Herzog B</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stoeger C</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Palacín M</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lahoutte T</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Camargo SM</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verrey F</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a09">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18259611</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Invest</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Simonides WS</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mulcahey MA</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Redout EM</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Muller A</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zuidwijk MJ</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Visser TJ</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wassen FW</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Crescenzi A</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">da-Silva WS</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Harney J</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Engel FB</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Obregon MJ</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Larsen PR</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bianco AC</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang SA</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb9">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21683758</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Endocrinol</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Massart C</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hoste C</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Virion A</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ruf J</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumont JE</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Sande J</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b7c">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">8222576</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thyroid hormone transport proteins.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clin Lab Med</bp:SOURCE>
+
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1993</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bartalena L</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Robbins J</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ab9">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ab9">
Line 3,493: Line 3,385:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Byrne JH</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Byrne JH</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eae">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c77">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17452290</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27693079</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Protein kinase C-regulated cAMP response element-binding protein phosphorylation in cultured rat striatal neurons.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Transcriptional regulation of the uncoupling protein-1 gene.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brain Res Bull</bp:SOURCE>
+
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Villarroya F</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peyrou M</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giralt M</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bd5">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21440011</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Akt, FoxO and regulation of apoptosis.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochim Biophys Acta</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang X</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tang N</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hadden TJ</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rishi AK</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 +
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM>
 +
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID>
 +
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 +
    </bp:openControlledVocabulary>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb1">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17574003</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">New insights into thyroid hormone action.</bp:TITLE>
 +
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Best Pract Res Clin Endocrinol Metab</bp:SOURCE>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mao LM</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oetting A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tang Q</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yen PM</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang JQ</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e06">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a0d">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">31076567</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20802499</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oncogenesis</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Med</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2019</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen J</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">López M</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bell J</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Varela L</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lau BT</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vázquez MJ</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Whittaker T</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rodríguez-Cuenca S</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stapleton D</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">González CR</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ji HP</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Velagapudi VR</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morgan DA</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schoenmakers E</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Agassandian K</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lage R</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Martínez de Morentin PB</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tovar S</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nogueiras R</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carling D</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lelliott C</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gallego R</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oresic M</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chatterjee K</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Saha AK</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rahmouni K</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diéguez C</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vidal-Puig A</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f7a">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e38">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27449104</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25330987</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NADPH: new oxygen for the ROS theory of aging.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A thyroid hormone receptor/KLF9 axis in human hepatocytes and pluripotent stem cells.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oncotarget</bp:SOURCE>
+
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stem Cells</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
+
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernandez-Marcos PJ</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cvoro A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nóbrega-Pereira S</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Devito L</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milton FA</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Noli L</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Filippi C</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sakai K</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Suh JH</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">H Sieglaff D</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dhawan A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sakai T</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ilic D</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Webb P</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e69">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15971998</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.</bp:TITLE>
 +
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem J</bp:SOURCE>
 +
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mîinea CP</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sano H</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kane S</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sano E</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fukuda M</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Peränen J</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lane WS</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lienhard GE</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d70">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d70">
Line 3,538: Line 3,497:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goetze JP</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Goetze JP</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a79">
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">12172553</bp:ID>
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID>
+
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
+
-
    </bp:openControlledVocabulary>
+
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ddc">
+
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27351946</bp:ID>
+
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Polymorphisms of iodothyronine deiodinases (DIO1, DIO3) genes are not associated with recurrent depressive disorder.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pharmacol Rep</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Cell Biol</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GaÅ‚ecka E</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Inoki K</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Talarowska M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Li Y</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maes M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhu T</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Su KP</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wu J</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Górski P</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guan KL</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Szemraj J</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ecc">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ecc">
Line 3,565: Line 3,518:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van den Heuvel JK</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van den Heuvel JK</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rensen PCN</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rensen PCN</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b90">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">23045339</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Physiol</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mariotta L</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ramadan T</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Singer D</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guetg A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Herzog B</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stoeger C</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Palacín M</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lahoutte T</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Camargo SM</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verrey F</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b47">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">24872083</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of adipocyte lipolysis.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nutr Res Rev</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frühbeck G</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Méndez-Giménez L</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernández-Formoso JA</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernández S</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rodríguez A</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a3e">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a3e">
Line 3,588: Line 3,570:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Salvatore D</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Salvatore D</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
 +
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 +
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">thyroid-stimulating hormone signaling pathway</bp:TERM>
 +
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0001200</bp:ID>
 +
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 +
    </bp:openControlledVocabulary>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c16">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c16">
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15</bp:ID>
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15</bp:ID>
Line 3,608: Line 3,595:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang JQ</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang JQ</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d09">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="afe">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21317437</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26207953</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thermogenic activation induces FGF21 expression and release in brown adipose tissue.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Endocrinol Metab</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hondares E</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aguayo-Mazzucato C</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iglesias R</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DiIenno A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giralt A</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hollister-Lock J</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gonzalez FJ</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cahill C</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giralt M</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sharma A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mampel T</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Weir G</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Villarroya F</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Colton C</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bonner-Weir S</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a7b">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a7b">
Line 3,636: Line 3,624:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Greenberg ME</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Greenberg ME</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eca">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c32">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">20167242</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29997323</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Efficient use and recycling of the micronutrient iodide in mammals.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Mol Sci</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rokita SE</bp:AUTHORS>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">29997323</bp:ID>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adler JM</bp:AUTHORS>
+
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McTamney PM</bp:AUTHORS>
+
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Integrating Thyroid Hormone Signaling in Hypothalamic Control of Metabolism: Crosstalk Between Nuclear Receptors.</bp:TITLE>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watson JA Jr</bp:AUTHORS>
+
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Mol Sci</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kouidhi S</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clerget-Froidevaux MS</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bcd">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f06">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28448947</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28235572</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Redox Biol</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Signal</bp:SOURCE>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Contreras C</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Houddane A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nogueiras R</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bultot L</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diéguez C</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Novellasdemunt L</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rahmouni K</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Johanns M</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">López M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gueuning MA</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Vertommen D</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Coulie PG</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bartrons R</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hue L</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rider MH</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e38">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ddc">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25330987</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">27351946</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A thyroid hormone receptor/KLF9 axis in human hepatocytes and pluripotent stem cells.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Polymorphisms of iodothyronine deiodinases (DIO1, DIO3) genes are not associated with recurrent depressive disorder.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stem Cells</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pharmacol Rep</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cvoro A</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">GaÅ‚ecka E</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Devito L</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Talarowska M</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Milton FA</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maes M</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Noli L</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Su KP</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang A</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Górski P</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Filippi C</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Szemraj J</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sakai K</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Suh JH</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">H Sieglaff D</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dhawan A</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sakai T</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ilic D</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Webb P</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ae1">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c93">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28723567</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28322461</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iodinated TG in Thyroid Follicular Lumen Regulates TTF-1 and PAX8 Expression via TSH/TSHR Signaling Pathway.</bp:TITLE>
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Cell Biochem</bp:SOURCE>
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">28723567</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.</bp:TITLE>
+
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Rep</bp:SOURCE>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yao L</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang H</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cui X</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shi Y</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen Q</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liang B</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yang X</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cai H</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fang F</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cai Q</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang J</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu G</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jin W</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chang Y</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bd5">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d09">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21440011</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21317437</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Akt, FoxO and regulation of apoptosis.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thermogenic activation induces FGF21 expression and release in brown adipose tissue.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochim Biophys Acta</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Biol Chem</bp:SOURCE>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang X</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hondares E</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tang N</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iglesias R</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hadden TJ</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giralt A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rishi AK</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gonzalez FJ</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giralt M</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mampel T</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Villarroya F</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b74">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f52">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22653837</bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11533250</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treatedwith sorafenib.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hepatology</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Biol</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Spirli C</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Miller LD</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morell CM</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Park KS</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Locatelli L</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guo QM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Okolicsanyi S</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alkharouf NW</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ferrero C</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Malek RL</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim AK</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee NH</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fabris L</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu ET</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fiorotto R</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng SY</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Strazzabosco M</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e06">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">31076567</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oncogenesis</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2019</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chen J</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bell J</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lau BT</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Whittaker T</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stapleton D</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ji HP</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 +
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">congenital hypothyroidism</bp:TERM>
 +
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0050328</bp:ID>
 +
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
 +
    </bp:openControlledVocabulary>
   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
108638view08:52, 14 January 2020Rik-lahaijechanged nodes
108396view20:35, 16 December 2019EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
108391view13:22, 16 December 2019Rik-lahaijelines
108390view13:13, 16 December 2019Rik-lahaijeModified description
108389view12:57, 16 December 2019Rik-lahaijeannotations
108388view12:52, 16 December 2019Rik-lahaijechanged legend
108387view12:46, 16 December 2019Rik-lahaije
108378view10:24, 15 December 2019Marvin M2Connected lines and converted some into graphical lines
108263view14:56, 3 December 2019L DupuisConverted interactions to graphical lines in legend
108262view14:55, 3 December 2019L DupuisConnected unconnected lines
108096view12:55, 28 November 2019FehrhartOntology Term : 'congenital hypothyroidism' added !
108095view12:52, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
107964view09:26, 18 November 2019FehrhartOntology Term : 'thyroid-stimulating hormone signaling pathway' added !
107960view09:14, 14 November 2019Rik-lahaijeModified description
107959view09:09, 14 November 2019Rik-lahaijeModified title
107958view09:09, 14 November 2019Rik-lahaijeNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/3/39/WP4746_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/3/39/WP4746_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 108638)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
Personal tools