Thyroid hormones production and their peripheral downstream signalling effects regarding congenital hypothyroidism (Homo sapiens)

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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Protein kinase C-regulated cAMP response element-binding protein phosphorylation in cultured rat striatal neurons.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brown adipose tissue and thermogenesis.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Transcriptional regulation of the uncoupling protein-1 gene.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Metabolic impact of the glycerol channelsAQP7 and AQP9 in adipose tissue and liver.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Mol Endocrinol</bp:SOURCE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Proc Natl Acad Sci U S A</bp:SOURCE>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Massart C</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ruf J</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ambrosio R</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumont JE</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Elefante A</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Sande J</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mirebeau-Prunier D</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fenzi G</bp:AUTHORS>
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      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">congenital hypothyroidism</bp:TERM>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Mol Endocrinol</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mariotta L</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Calebiro D</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ramadan T</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nikolaev VO</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Singer D</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lohse MJ</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guetg A</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stoeger C</bp:AUTHORS>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The MCT8 thyroid hormone transporter and Allan-Herndon-Dudley syndrome.</bp:TITLE>
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      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Best Pract Res Clin Endocrinol Metab</bp:SOURCE>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stevenson RE</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ji HP</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ji HP</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b74">
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      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM>
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      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID>
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      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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    </bp:openControlledVocabulary>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bcd">
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       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treatedwith sorafenib.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Redox Biol</bp:SOURCE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hepatology</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Contreras C</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Spirli C</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nogueiras R</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Morell CM</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Diéguez C</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Locatelli L</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rahmouni K</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Okolicsanyi S</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">López M</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ferrero C</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim AK</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fabris L</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fiorotto R</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Strazzabosco M</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cf5">
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DIO2 modifies inflammatory responses in chondrocytes.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Biol</bp:SOURCE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Osteoarthritis Cartilage</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2001</bp:YEAR>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2012</bp:YEAR>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Miller LD</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng AW</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Park KS</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bolognesi M</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guo QM</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kraus VB</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alkharouf NW</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Malek RL</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lee NH</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu ET</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng SY</bp:AUTHORS>
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    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb1">
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">New insights into thyroid hormone action.</bp:TITLE>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oetting A</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kopp P</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb9">
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16870170</bp:ID>
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       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molecular advances in thyroglobulin disorders.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clin Chim Acta</bp:SOURCE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Endocrinol</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rivolta CM</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Massart C</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Targovnik HM</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hoste C</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Virion A</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ruf J</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumont JE</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Sande J</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b47">
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Roles of hydrogen peroxide in thyroid physiology and disease.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Regulation of adipocyte lipolysis.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Endocrinol Metab</bp:SOURCE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nutr Res Rev</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Song Y</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frühbeck G</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Driessens N</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Méndez-Giménez L</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Costa M</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernández-Formoso JA</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De Deken X</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernández S</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Detours V</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rodríguez A</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Corvilain B</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maenhaut C</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumont JE</bp:AUTHORS>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Inherited defects of thyroid hormone metabolism.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ann Endocrinol (Paris)</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2011</bp:YEAR>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schakman O</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dumitrescu AM</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kalista S</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Refetoff S</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d09">
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">22653837</bp:ID>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treatedwith sorafenib.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thermogenic activation induces FGF21 expression and release in brown adipose tissue.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hepatology</bp:SOURCE>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Molecular advances in thyroglobulin disorders.</bp:TITLE>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hue L</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Camargo SM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rider MH</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Verrey F</bp:AUTHORS>
     </bp:PublicationXref>
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-
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       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Efficient use and recycling of the micronutrient iodide in mammals.</bp:TITLE>
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
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+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">21448409</bp:ID>
+
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+
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iodine, Iodine metabolism and Iodine deficiency disorders revisited.</bp:TITLE>
+
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Indian J Endocrinol Metab</bp:SOURCE>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ahad F</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rokita SE</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ganie SA</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Adler JM</bp:AUTHORS>
-
    </bp:PublicationXref>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">McTamney PM</bp:AUTHORS>
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a7b">
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watson JA Jr</bp:AUTHORS>
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      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">9346240</bp:ID>
+
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell</bp:SOURCE>
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-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1997</bp:YEAR>
+
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Datta SR</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dudek H</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tao X</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Masters S</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fu H</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gotoh Y</bp:AUTHORS>
+
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Greenberg ME</bp:AUTHORS>
+
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f7a">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f7a">
Line 3,555: Line 3,485:
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernandez-Marcos PJ</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fernandez-Marcos PJ</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nóbrega-Pereira S</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nóbrega-Pereira S</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="fc4">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="afe">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15964803</bp:ID>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26207953</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Cell Biol</bp:SOURCE>
+
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Clin Endocrinol Metab</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR>
+
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Robidoux J</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Aguayo-Mazzucato C</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cao W</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DiIenno A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Quan H</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hollister-Lock J</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Daniel KW</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cahill C</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moukdar F</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sharma A</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bai X</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Weir G</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Floering LM</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Colton C</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Collins S</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bonner-Weir S</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ab9">
 +
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 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bifurcation and singularity analysis of a molecular network for the induction of long-term memory.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biophys J</bp:SOURCE>
 +
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 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Song H</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Smolen P</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Av-Ron E</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Baxter DA</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Byrne JH</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb1">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17574003</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">New insights into thyroid hormone action.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Best Pract Res Clin Endocrinol Metab</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Oetting A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yen PM</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c2e">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11149600</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Thyroid transcription factor 1 phosphorylation is not required for protein kinase A-dependent transcription of the thyroglobulin promoter.</bp:TITLE>
 +
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Growth Differ</bp:SOURCE>
 +
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2000</bp:YEAR>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Feliciello A</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Allevato G</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Musti AM</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">De Brasi D</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gallo A</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Avvedimento VE</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gottesman ME</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ecc">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">26482876</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Neuronal Control of Brown Fat Activity.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Trends Endocrinol Metab</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2015</bp:YEAR>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kooijman S</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">van den Heuvel JK</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rensen PCN</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c16">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17452290</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17452290</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Protein kinase C-regulated cAMP response element-binding protein phosphorylation in cultured rat striatal neurons.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brain Res Bull</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2007</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mao LM</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tang Q</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang JQ</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
108263view14:56, 3 December 2019L DupuisConverted interactions to graphical lines in legend
108262view14:55, 3 December 2019L DupuisConnected unconnected lines
108096view12:55, 28 November 2019FehrhartOntology Term : 'congenital hypothyroidism' added !
108095view12:52, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
107964view09:26, 18 November 2019FehrhartOntology Term : 'thyroid-stimulating hormone signaling pathway' added !
107960view09:14, 14 November 2019Rik-lahaijeModified description
107959view09:09, 14 November 2019Rik-lahaijeModified title
107958view09:09, 14 November 2019Rik-lahaijeNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/3/39/WP4746_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/3/39/WP4746_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 108263)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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