Endochondral Ossification (Homo sapiens)

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1, 2GsVascular invastionBMPsFull differentiationHypertrophyProliferationRemoval of extracellular matrixand invasion by bone cellsChondrocyte deathMineralisationChondrocyte proliferationBoneChondrocyte (pre)hypertrophyCartilageRemoval of cartilage matrixCathepsinsand CalpainsOsteoblasticdifferentiation?WNT signalingcanonical / non-canonicalintegrinsDyingCOL2A1SOX5BMP7STAT1DDR2FGF18FrzB-1FGFR3Cathepsin L2OxygenThyroid hormoneMGPAggrecanNPP1PTCH1RUNX2CAB39ADAMTS4PKAIGF1PLATIHHBapx1IGF1RTGFB1OsteopontinPTHFGF2PTCHMEF2CGrowth hormoneSLC38A2RUNX2MMP13SOX6ADAMTS5THRAcAMPKIF3ASTAT5RUNX2TNAPIGF2RUNX3GH receptorTriiodothyronineC4ST1FGFR1VEGFAADAMTS1BMPR1APLAUAKP2PTHR1CALM1TIMP3CarminerinTGFBIThyroid hormoneSERPINH1BMP6TG737AdseverinGLI3HDAC4PTHrPSox9THRACOL10A1HMGCS1MMP9TGFB2AKTCDKN1C


Description

No description

Quality Tags

Ontology Terms

 

Bibliography

  1. Randau TM, Schildberg FA, Alini M, Wimmer MD, Haddouti el-M, Gravius S, Ito K, Stoddart MJ; ''The effect of dexamethasone and triiodothyronine on terminal differentiation of primary bovine chondrocytes and chondrogenically differentiated mesenchymal stem cells.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  3. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106812view13:29, 17 September 2019MaintBotHMDB identifier normalization
106400view21:31, 28 August 2019KhanspersModified description
105580view06:42, 9 August 2019KhanspersModified description
95499view13:36, 18 December 2017DeSlAdded additional literature reference, changed unconnected lines to graphical lines.
95498view13:33, 18 December 2017DeSlModified description
95497view13:32, 18 December 2017DeSlModified description
95220view17:50, 26 November 2017DeSlChanged unconnected lines to graphical lines (where applicable).
87977view13:18, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80208view20:59, 22 May 2015KhanspersReverted to version '05:03, 25 October 2013' by Khanspers
80164view21:19, 14 May 2015KhanspersAdded mir499a targeting of SOX6
72122view05:03, 25 October 2013EgonwAdded missing metabolite identifiers.
63180view20:42, 8 May 2013MaintBotUpdating gpml version
45241view18:23, 7 October 2011AlexanderPicoOntology Term : 'osteochondroclast' added !
45003view15:53, 6 October 2011LarsEijssenOntology Term : 'osteoclast' added !
45001view15:52, 6 October 2011LarsEijssenOntology Term : 'chondrocyte' added !
45000view15:47, 6 October 2011LarsEijssenModified description
44999view14:45, 6 October 2011LarsEijssenadapted types of groups where relevant
41222view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
32442view17:18, 15 August 2009MaintBotFixed text labels
32115view13:50, 14 August 2009MaintBotFixed group labels
29737view22:33, 1 June 2009KhanspersModified categories
28899view15:55, 11 March 2009AllaPeriodical save, work in progress
21676view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Endochondral Ossification]] moved to [[Pathway:WP474]]: Moved to stable identifier
19039view11:03, 16 September 2008LarsEijssenTwo genes changed to CAPS
19033view09:44, 16 September 2008LarsEijssenadded some missing Entrez gene IDs, removed a duplicate gene SPP1, changed Gs into label
16584view19:30, 22 June 2008AlexanderPicoconnected example nodes to database
16120view12:00, 11 June 2008LarsEijssenfixed data node types
16118view11:28, 11 June 2008LarsEijssenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAMTS1GeneProduct9510 (Entrez Gene)
ADAMTS4GeneProduct9507 (Entrez Gene)
ADAMTS5GeneProduct11096 (Entrez Gene)
AKP2GeneProduct249 (Entrez Gene)
AKTGeneProduct207 (Entrez Gene)
AdseverinGeneProduct85477 (Entrez Gene) PMID: 17097081
AggrecanGeneProduct176 (Entrez Gene)
BMP6GeneProduct654 (Entrez Gene)
BMP7GeneProduct655 (Entrez Gene)
BMPR1AGeneProduct657 (Entrez Gene)
Bapx1GeneProduct579 (Entrez Gene)
C4ST1GeneProduct50515 (Entrez Gene)
CAB39GeneProduct51719 (Entrez Gene)
CALM1GeneProduct801 (Entrez Gene)
CDKN1CGeneProduct1028 (Entrez Gene)
COL10A1GeneProduct1300 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
CarminerinGeneProduct1473 (Entrez Gene)
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
Cathepsin L2GeneProduct1515 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
DDR2GeneProduct4921 (Entrez Gene)
FGF18GeneProduct8817 (Entrez Gene)
FGF2GeneProduct2247 (Entrez Gene)
FGFR1GeneProduct2260 (Entrez Gene)
FGFR3GeneProduct2261 (Entrez Gene)
FrzB-1GeneProduct2487 (Entrez Gene)
GH receptorGeneProduct2690 (Entrez Gene)
GLI3GeneProduct2737 (Entrez Gene)
Growth hormoneGeneProduct2688 (Entrez Gene)
HDAC4GeneProduct9759 (Entrez Gene)
HMGCS1GeneProduct3157 (Entrez Gene)
IGF1GeneProduct3479 (Entrez Gene)
IGF1RGeneProduct3480 (Entrez Gene)
IGF2GeneProduct3481 (Entrez Gene)
IHHGeneProduct3549 (Entrez Gene)
KIF3AGeneProduct11127 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MGPGeneProduct4256 (Entrez Gene)
MMP13GeneProduct4322 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
NPP1GeneProduct5167 (Entrez Gene)
OsteopontinGeneProduct6696 (Entrez Gene)
OxygenMetaboliteHMDB01377 (HMDB)
PKAGeneProduct5566 (Entrez Gene)
PLATGeneProduct5327 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PTCH1GeneProduct5727 (Entrez Gene)
PTCHGeneProduct5727 (Entrez Gene)
PTHGeneProduct5741 (Entrez Gene)
PTHR1GeneProduct5745 (Entrez Gene)
PTHrPGeneProduct5744 (Entrez Gene)
RUNX2GeneProduct860 (Entrez Gene)
RUNX3GeneProduct864 (Entrez Gene)
SERPINH1GeneProduct871 (Entrez Gene)
SLC38A2GeneProduct54407 (Entrez Gene)
SOX5GeneProduct6660 (Entrez Gene)
SOX6GeneProduct55553 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT5GeneProduct6777 (Entrez Gene)
Sox9GeneProduct6662 (Entrez Gene)
TG737GeneProduct8100 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFBIGeneProduct7040 (Entrez Gene)
THRAGeneProduct7067 (Entrez Gene)
TIMP3GeneProduct7078 (Entrez Gene)
TNAPGeneProduct445341 (Entrez Gene)
Thyroid hormoneMetaboliteT4
TriiodothyronineMetaboliteT3
VEGFAGeneProduct7422 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions

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