Endochondral Ossification (Homo sapiens)

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1, 2Full differentiationintegrinsDying?Chondrocyte deathBoneRemoval of extracellular matrixand invasion by bone cellsChondrocyte (pre)hypertrophyChondrocyte proliferationBMPsWNT signalingcanonical / non-canonicalHypertrophyRemoval of cartilage matrixMineralisationCathepsinsand CalpainsProliferationOsteoblasticdifferentiationVascular invastionCartilageFGF18DDR2RUNX2FrzB-1FGF2Thyroid hormoneTGFB2TriiodothyronineADAMTS1HDAC4CALM1PLATSTAT1TNAPCAB39FGFR1MGPOxygenGLI3NPP1ADAMTS4AdseverinRUNX2AKTSox6THRACOL10A1BMP6cAMPRUNX2FGFR3IHHRUNX3CarminerinSPP1TIMP3COL2A1MMP13MMP9IGF1PTHR1IGF1RGsTG737STAT5C4ST1THRABMPR1AAggrecanTGFBISLC38A2Cathepsin L2MEF2CBMP7ADAMTS5VEGFAPTCHSERPINH1PTCH1KIF3AAKP2TGFB1CDKN1CSox9PTHrPThyroid hormoneSox5IGF2PKAGrowth hormonePTHPLAUBapx1OsteopontinGH receptorHMGCS1


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Ontology Terms



  1. Randau TM, Schildberg FA, Alini M, Wimmer MD, Haddouti el-M, Gravius S, Ito K, Stoddart MJ; ''The effect of dexamethasone and triiodothyronine on terminal differentiation of primary bovine chondrocytes and chondrogenically differentiated mesenchymal stem cells.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  3. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia


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106812view13:29, 17 September 2019MaintBotHMDB identifier normalization
106400view21:31, 28 August 2019KhanspersModified description
105580view06:42, 9 August 2019KhanspersModified description
95499view13:36, 18 December 2017DeSlAdded additional literature reference, changed unconnected lines to graphical lines.
95498view13:33, 18 December 2017DeSlModified description
95497view13:32, 18 December 2017DeSlModified description
95220view17:50, 26 November 2017DeSlChanged unconnected lines to graphical lines (where applicable).
87977view13:18, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80208view20:59, 22 May 2015KhanspersReverted to version '05:03, 25 October 2013' by Khanspers
80164view21:19, 14 May 2015KhanspersAdded mir499a targeting of SOX6
72122view05:03, 25 October 2013EgonwAdded missing metabolite identifiers.
63180view20:42, 8 May 2013MaintBotUpdating gpml version
45241view18:23, 7 October 2011AlexanderPicoOntology Term : 'osteochondroclast' added !
45003view15:53, 6 October 2011LarsEijssenOntology Term : 'osteoclast' added !
45001view15:52, 6 October 2011LarsEijssenOntology Term : 'chondrocyte' added !
45000view15:47, 6 October 2011LarsEijssenModified description
44999view14:45, 6 October 2011LarsEijssenadapted types of groups where relevant
41222view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
32442view17:18, 15 August 2009MaintBotFixed text labels
32115view13:50, 14 August 2009MaintBotFixed group labels
29737view22:33, 1 June 2009KhanspersModified categories
28899view15:55, 11 March 2009AllaPeriodical save, work in progress
21676view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Endochondral Ossification]] moved to [[Pathway:WP474]]: Moved to stable identifier
19039view11:03, 16 September 2008LarsEijssenTwo genes changed to CAPS
19033view09:44, 16 September 2008LarsEijssenadded some missing Entrez gene IDs, removed a duplicate gene SPP1, changed Gs into label
16584view19:30, 22 June 2008AlexanderPicoconnected example nodes to database
16120view12:00, 11 June 2008LarsEijssenfixed data node types
16118view11:28, 11 June 2008LarsEijssenNew pathway

External references


View all...
NameTypeDatabase referenceComment
ADAMTS1GeneProduct9510 (Entrez Gene)
ADAMTS4GeneProduct9507 (Entrez Gene)
ADAMTS5GeneProduct11096 (Entrez Gene)
AKTUnknown207 (Entrez Gene)
AdseverinGeneProduct85477 (Entrez Gene) PMID: 17097081
AggrecanGeneProduct176 (Entrez Gene)
BMP6Unknown654 (Entrez Gene)
BMP7Unknown655 (Entrez Gene)
BMPR1AUnknown657 (Entrez Gene)
Bapx1GeneProduct579 (Entrez Gene)
C4ST1GeneProduct50515 (Entrez Gene)
COL10A1Unknown1300 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
CarminerinUnknown1473 (Entrez Gene)
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
Cathepsin L2GeneProduct1515 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
DDR2GeneProduct4921 (Entrez Gene)
FGF18GeneProduct8817 (Entrez Gene)
FGF2GeneProduct2247 (Entrez Gene)
FrzB-1GeneProduct2487 (Entrez Gene)
GH receptorUnknown2690 (Entrez Gene)
GLI3Unknown2737 (Entrez Gene)
Growth hormoneUnknown2688 (Entrez Gene)
HDAC4GeneProduct9759 (Entrez Gene)
IGF1Unknown3479 (Entrez Gene)
IGF1RUnknown3480 (Entrez Gene)
IGF2Unknown3481 (Entrez Gene)
IHHUnknown3549 (Entrez Gene)
KIF3AUnknown11127 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MMP13GeneProduct4322 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
NPP1Unknown5167 (Entrez Gene)
OsteopontinUnknown6696 (Entrez Gene)
PKAUnknown5566 (Entrez Gene)
PLATGeneProduct5327 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PTCHUnknown5727 (Entrez Gene)
PTHUnknown5741 (Entrez Gene)
PTHR1Unknown5745 (Entrez Gene)
PTHrPUnknown5744 (Entrez Gene)
RUNX2Unknown860 (Entrez Gene)
RUNX3GeneProduct864 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT5Unknown6777 (Entrez Gene)
Sox5GeneProduct6660 (Entrez Gene)
Sox6GeneProduct55553 (Entrez Gene)
Sox9Unknown6662 (Entrez Gene)
TG737Unknown8100 (Entrez Gene)
TGFB1Unknown7040 (Entrez Gene)
TGFB2Unknown7042 (Entrez Gene)
THRAUnknown7067 (Entrez Gene)
TNAPUnknown445341 (Entrez Gene)
Thyroid hormoneMetaboliteT4
VEGFAUnknown7422 (Entrez Gene)

Annotated Interactions

No annotated interactions

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