Melanoma (Homo sapiens)

From WikiPathways

(Difference between revisions)
Jump to: navigation, search
(HMDB identifier normalization)
(Modified description)
Line 1: Line 1:
<?xml version="1.0" encoding="UTF-8"?>
<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Melanoma" Version="20190813" Organism="Homo sapiens">
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Melanoma" Version="20190813" Organism="Homo sapiens">
-
   <Comment Source="WikiPathways-description">draft</Comment>
+
   <Comment Source="WikiPathways-description">Melanoma, or malignant melanoma, is a highly aggressive cancer that develops in melanocytes. Many genes have been found to be mutated or amplified in melanoma, with the most commonly mutated genes being BRAF, CDKN2A, NRAS and TP53. MAPK and PI3K/Akt signaling are central to melanoma.
 +
 
 +
This pathway is a summary of information from figures 1 and 2 from [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520749/ Kunz and Vera] and supplemented with information from [https://www.kegg.jp/dbget-bin/www_bget?pathway+hsa05218 KEGG]. </Comment>
   <BiopaxRef>fab</BiopaxRef>
   <BiopaxRef>fab</BiopaxRef>
   <BiopaxRef>ca0</BiopaxRef>
   <BiopaxRef>ca0</BiopaxRef>
-
   <Graphics BoardWidth="1250.0" BoardHeight="1264.0" />
+
   <Graphics BoardWidth="1250.0" BoardHeight="1264.0"/>
   <DataNode TextLabel="KRAS" GraphId="b62ea" Type="GeneProduct" GroupRef="d1e03">
   <DataNode TextLabel="KRAS" GraphId="b62ea" Type="GeneProduct" GroupRef="d1e03">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="KRAS | v-Ki-ras2 Kirsten rat sarcoma viral onco..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="KRAS | v-Ki-ras2 Kirsten rat sarcoma viral onco..."/>
-
     <Graphics CenterX="652.0" CenterY="378.787557440792" Width="60.0" Height="25.0" ZOrder="-4" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.0" CenterY="378.787557440792" Width="60.0" Height="25.0" ZOrder="-4" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="3845" />
+
     <Xref Database="Entrez Gene" ID="3845"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NRAS" GraphId="a4836" Type="GeneProduct" GroupRef="d1e03">
   <DataNode TextLabel="NRAS" GraphId="a4836" Type="GeneProduct" GroupRef="d1e03">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NRAS | neuroblastoma RAS viral (v-ras) oncogene..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="NRAS | neuroblastoma RAS viral (v-ras) oncogene..."/>
-
     <Graphics CenterX="652.0" CenterY="403.787557440792" Width="60.0" Height="25.0" ZOrder="-2" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.0" CenterY="403.787557440792" Width="60.0" Height="25.0" ZOrder="-2" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="4893" />
+
     <Xref Database="Entrez Gene" ID="4893"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ETS1" GraphId="a338f" Type="GeneProduct" GroupRef="d89cb">
   <DataNode TextLabel="ETS1" GraphId="a338f" Type="GeneProduct" GroupRef="d89cb">
-
     <Graphics CenterX="652.1332167384685" CenterY="1065.824297231583" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.1332167384685" CenterY="1065.824297231583" Width="60.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000134954" />
+
     <Xref Database="Ensembl" ID="ENSG00000134954"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GRM3" GraphId="a5e54" Type="GeneProduct">
   <DataNode TextLabel="GRM3" GraphId="a5e54" Type="GeneProduct">
     <BiopaxRef>d7a</BiopaxRef>
     <BiopaxRef>d7a</BiopaxRef>
-
     <Graphics CenterX="335.07142857142867" CenterY="124.8095238095238" Width="70.71428571428565" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="335.07142857142867" CenterY="124.8095238095238" Width="70.71428571428565" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000198822" />
+
     <Xref Database="Ensembl" ID="ENSG00000198822"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NF1" GraphId="a83c8" Type="GeneProduct">
   <DataNode TextLabel="NF1" GraphId="a83c8" Type="GeneProduct">
     <BiopaxRef>b44</BiopaxRef>
     <BiopaxRef>b44</BiopaxRef>
-
     <Graphics CenterX="756.0" CenterY="403.0" Width="70.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="756.0" CenterY="403.0" Width="70.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000196712" />
+
     <Xref Database="Ensembl" ID="ENSG00000196712"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VCL" GraphId="b5476" Type="GeneProduct">
   <DataNode TextLabel="VCL" GraphId="b5476" Type="GeneProduct">
-
     <Graphics CenterX="140.0238095238096" CenterY="295.52380952380975" Width="68.80952380952391" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="140.0238095238096" CenterY="295.52380952380975" Width="68.80952380952391" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000035403" />
+
     <Xref Database="Ensembl" ID="ENSG00000035403"/>
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="p38 MAPK &#xA;Signaling" GraphId="bf79d" Type="Pathway">
+
   <DataNode TextLabel="p38 MAPK &#10;Signaling" GraphId="bf79d" Type="Pathway">
-
     <Graphics CenterX="252.2857142857144" CenterY="437.4285714285715" Width="90.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" />
+
     <Graphics CenterX="252.2857142857144" CenterY="437.4285714285715" Width="90.0" Height="25.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e"/>
-
     <Xref Database="WikiPathways" ID="WP400" />
+
     <Xref Database="WikiPathways" ID="WP400"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RAC1" GraphId="c1a2a" Type="GeneProduct">
   <DataNode TextLabel="RAC1" GraphId="c1a2a" Type="GeneProduct">
Line 41: Line 43:
     <BiopaxRef>b44</BiopaxRef>
     <BiopaxRef>b44</BiopaxRef>
     <BiopaxRef>cb5</BiopaxRef>
     <BiopaxRef>cb5</BiopaxRef>
-
     <Graphics CenterX="193.16666666666663" CenterY="243.85714285714266" Width="67.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="193.16666666666663" CenterY="243.85714285714266" Width="67.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000136238" />
+
     <Xref Database="Ensembl" ID="ENSG00000136238"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="KDR" GraphId="c4c5c" Type="GeneProduct">
   <DataNode TextLabel="KDR" GraphId="c4c5c" Type="GeneProduct">
     <BiopaxRef>b44</BiopaxRef>
     <BiopaxRef>b44</BiopaxRef>
-
     <Graphics CenterX="852.4999999999998" CenterY="122.09523809523813" Width="61.19047619047615" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="852.4999999999998" CenterY="122.09523809523813" Width="61.19047619047615" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000128052" />
+
     <Xref Database="Ensembl" ID="ENSG00000128052"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="KIT" GraphId="c882f" Type="GeneProduct">
   <DataNode TextLabel="KIT" GraphId="c882f" Type="GeneProduct">
     <BiopaxRef>b44</BiopaxRef>
     <BiopaxRef>b44</BiopaxRef>
     <BiopaxRef>d64</BiopaxRef>
     <BiopaxRef>d64</BiopaxRef>
-
     <Graphics CenterX="970.1190476190476" CenterY="122.09523809523813" Width="50.71428571428578" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="970.1190476190476" CenterY="122.09523809523813" Width="50.71428571428578" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000157404" />
+
     <Xref Database="Ensembl" ID="ENSG00000157404"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ERBB4" GraphId="d0958" Type="GeneProduct">
   <DataNode TextLabel="ERBB4" GraphId="d0958" Type="GeneProduct">
     <BiopaxRef>afe</BiopaxRef>
     <BiopaxRef>afe</BiopaxRef>
-
     <Graphics CenterX="1102.547619047619" CenterY="124.09523809523813" Width="69.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="1102.547619047619" CenterY="124.09523809523813" Width="69.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000178568" />
+
     <Xref Database="Ensembl" ID="ENSG00000178568"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PREX2" GraphId="da366" Type="GeneProduct">
   <DataNode TextLabel="PREX2" GraphId="da366" Type="GeneProduct">
     <BiopaxRef>e15</BiopaxRef>
     <BiopaxRef>e15</BiopaxRef>
-
     <Graphics CenterX="1084.0" CenterY="634.0" Width="64.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="1084.0" CenterY="634.0" Width="64.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000046889" />
+
     <Xref Database="Ensembl" ID="ENSG00000046889"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="STK19" GraphId="dadaf" Type="GeneProduct">
   <DataNode TextLabel="STK19" GraphId="dadaf" Type="GeneProduct">
     <BiopaxRef>a2f</BiopaxRef>
     <BiopaxRef>a2f</BiopaxRef>
-
     <Graphics CenterX="687.4285714285713" CenterY="289.6666666666665" Width="53.71428571428589" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="687.4285714285713" CenterY="289.6666666666665" Width="53.71428571428589" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000204344" />
+
     <Xref Database="Ensembl" ID="ENSG00000204344"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PAK1" GraphId="ee2b4" Type="GeneProduct">
   <DataNode TextLabel="PAK1" GraphId="ee2b4" Type="GeneProduct">
-
     <Graphics CenterX="193.16666666666663" CenterY="336.85714285714266" Width="63.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="193.16666666666663" CenterY="336.85714285714266" Width="63.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000149269" />
+
     <Xref Database="Ensembl" ID="ENSG00000149269"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Vemurafenib" GraphId="f03f2" Type="Metabolite" GroupRef="d04cd">
   <DataNode TextLabel="Vemurafenib" GraphId="f03f2" Type="Metabolite" GroupRef="d04cd">
-
     <Graphics CenterX="529.1335350043216" CenterY="567.0847018150389" Width="79.57216940363003" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="529.1335350043216" CenterY="567.0847018150389" Width="79.57216940363003" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:63637" />
+
     <Xref Database="ChEBI" ID="CHEBI:63637"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Sorafenib" GraphId="f23de" Type="Metabolite" GroupRef="d04cd">
   <DataNode TextLabel="Sorafenib" GraphId="f23de" Type="Metabolite" GroupRef="d04cd">
-
     <Graphics CenterX="529.1335350043216" CenterY="510.17026793431296" Width="79.57216940363003" Height="25.00000000000001" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="529.1335350043216" CenterY="510.17026793431296" Width="79.57216940363003" Height="25.00000000000001" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="HMDB" ID="HMDB0014542" />
+
     <Xref Database="HMDB" ID="HMDB0014542"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GRB2" GraphId="bb9d1" Type="GeneProduct" GroupRef="feed9">
   <DataNode TextLabel="GRB2" GraphId="bb9d1" Type="GeneProduct" GroupRef="feed9">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2 | growth factor receptor-bound protein 2" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2 | growth factor receptor-bound protein 2"/>
-
     <Graphics CenterX="676.698934024776" CenterY="174.9623307404207" Width="60.0" Height="25.0" ZOrder="32811" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="676.698934024776" CenterY="174.9623307404207" Width="60.0" Height="25.0" ZOrder="32811" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2885" />
+
     <Xref Database="Entrez Gene" ID="2885"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOS2" GraphId="b92fa" Type="GeneProduct" GroupRef="feed9">
   <DataNode TextLabel="SOS2" GraphId="b92fa" Type="GeneProduct" GroupRef="feed9">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOS2 | son of sevenless homolog 2 (Drosophila)" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOS2 | son of sevenless homolog 2 (Drosophila)"/>
-
     <Graphics CenterX="654.531619129933" CenterY="226.00734658599873" Width="60.0" Height="25.0" ZOrder="33270" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="654.531619129933" CenterY="226.00734658599873" Width="60.0" Height="25.0" ZOrder="33270" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="6655" />
+
     <Xref Database="Entrez Gene" ID="6655"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOS1" GraphId="bdab4" Type="GeneProduct" GroupRef="feed9">
   <DataNode TextLabel="SOS1" GraphId="bdab4" Type="GeneProduct" GroupRef="feed9">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOS2 | son of sevenless homolog 2 (Drosophila)" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SOS2 | son of sevenless homolog 2 (Drosophila)"/>
-
     <Graphics CenterX="654.531619129933" CenterY="201.00734658599868" Width="60.0" Height="25.0" ZOrder="33271" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="654.531619129933" CenterY="201.00734658599868" Width="60.0" Height="25.0" ZOrder="33271" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000115904" />
+
     <Xref Database="Ensembl" ID="ENSG00000115904"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HRAS" GraphId="d2061" Type="GeneProduct" GroupRef="d1e03">
   <DataNode TextLabel="HRAS" GraphId="d2061" Type="GeneProduct" GroupRef="d1e03">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MRAS | muscle RAS oncogene homolog" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MRAS | muscle RAS oncogene homolog"/>
-
     <Graphics CenterX="652.0" CenterY="428.787557440792" Width="60.0" Height="25.0" ZOrder="33273" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.0" CenterY="428.787557440792" Width="60.0" Height="25.0" ZOrder="33273" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000174775" />
+
     <Xref Database="Ensembl" ID="ENSG00000174775"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ARAF" GraphId="fd799" Type="GeneProduct" GroupRef="c2665">
   <DataNode TextLabel="ARAF" GraphId="fd799" Type="GeneProduct" GroupRef="c2665">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MOS | v-mos Moloney murine sarcoma viral oncoge..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MOS | v-mos Moloney murine sarcoma viral oncoge..."/>
-
     <Graphics CenterX="652.3333333333334" CenterY="574.588677888971" Width="60.0" Height="25.0" ZOrder="33286" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.3333333333334" CenterY="574.588677888971" Width="60.0" Height="25.0" ZOrder="33286" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000078061" />
+
     <Xref Database="Ensembl" ID="ENSG00000078061"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="BRAF" GraphId="add26" Type="GeneProduct" GroupRef="c2665">
   <DataNode TextLabel="BRAF" GraphId="add26" Type="GeneProduct" GroupRef="c2665">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BRAF | v-raf murine sarcoma viral oncogene homo..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BRAF | v-raf murine sarcoma viral oncogene homo..."/>
-
     <Graphics CenterX="652.3333333333334" CenterY="524.588677888971" Width="60.0" Height="25.0" ZOrder="33287" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.3333333333334" CenterY="524.588677888971" Width="60.0" Height="25.0" ZOrder="33287" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="673" />
+
     <Xref Database="Entrez Gene" ID="673"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RAF1" GraphId="de9ef" Type="GeneProduct" GroupRef="c2665">
   <DataNode TextLabel="RAF1" GraphId="de9ef" Type="GeneProduct" GroupRef="c2665">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1 | v-raf-1 murine leukemia viral oncogene h..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAF1 | v-raf-1 murine leukemia viral oncogene h..."/>
-
     <Graphics CenterX="652.3333333333334" CenterY="549.588677888971" Width="60.0" Height="25.0" ZOrder="33288" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.3333333333334" CenterY="549.588677888971" Width="60.0" Height="25.0" ZOrder="33288" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5894" />
+
     <Xref Database="Entrez Gene" ID="5894"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAP2K1" GraphId="fb416" Type="GeneProduct" GroupRef="c1818">
   <DataNode TextLabel="MAP2K1" GraphId="fb416" Type="GeneProduct" GroupRef="c1818">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K1 | mitogen-activated protein kinase kinas..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K1 | mitogen-activated protein kinase kinas..."/>
-
     <Graphics CenterX="652.3333333333333" CenterY="676.588677888971" Width="60.0" Height="25.0" ZOrder="33295" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.3333333333333" CenterY="676.588677888971" Width="60.0" Height="25.0" ZOrder="33295" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5604" />
+
     <Xref Database="Entrez Gene" ID="5604"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAPK1" GraphId="dd167" Type="GeneProduct" GroupRef="faf35">
   <DataNode TextLabel="MAPK1" GraphId="dd167" Type="GeneProduct" GroupRef="faf35">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK1 | mitogen-activated protein kinase 1" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK1 | mitogen-activated protein kinase 1"/>
-
     <Graphics CenterX="652.2338935574229" CenterY="779.7287339113801" Width="60.0" Height="25.0" ZOrder="33298" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.2338935574229" CenterY="779.7287339113801" Width="60.0" Height="25.0" ZOrder="33298" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5594" />
+
     <Xref Database="Entrez Gene" ID="5594"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAPK3" GraphId="e98e0" Type="GeneProduct" GroupRef="faf35">
   <DataNode TextLabel="MAPK3" GraphId="e98e0" Type="GeneProduct" GroupRef="faf35">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3 | mitogen-activated protein kinase 3" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK3 | mitogen-activated protein kinase 3"/>
-
     <Graphics CenterX="652.2338935574229" CenterY="804.7287339113802" Width="60.0" Height="25.0" ZOrder="33301" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.2338935574229" CenterY="804.7287339113802" Width="60.0" Height="25.0" ZOrder="33301" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5595" />
+
     <Xref Database="Entrez Gene" ID="5595"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MP1" GraphId="ebd40" Type="GeneProduct">
   <DataNode TextLabel="MP1" GraphId="ebd40" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K1IP1 | mitogen-activated protein kinase ki..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K1IP1 | mitogen-activated protein kinase ki..."/>
-
     <Graphics CenterX="732.6526610644257" CenterY="659.733893557423" Width="60.0" Height="25.0" ZOrder="33304" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="732.6526610644257" CenterY="659.733893557423" Width="60.0" Height="25.0" ZOrder="33304" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="8649" />
+
     <Xref Database="Entrez Gene" ID="8649"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAP2K2" GraphId="b2cfe" Type="GeneProduct" GroupRef="c1818">
   <DataNode TextLabel="MAP2K2" GraphId="b2cfe" Type="GeneProduct" GroupRef="c1818">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K2 | mitogen-activated protein kinase kinas..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP2K2 | mitogen-activated protein kinase kinas..."/>
-
     <Graphics CenterX="652.3333333333333" CenterY="701.588677888971" Width="60.0" Height="25.0" ZOrder="33305" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.3333333333333" CenterY="701.588677888971" Width="60.0" Height="25.0" ZOrder="33305" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="5605" />
+
     <Xref Database="Entrez Gene" ID="5605"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SHC2" GraphId="d0bb0" Type="GeneProduct" GroupRef="feed9">
   <DataNode TextLabel="SHC2" GraphId="d0bb0" Type="GeneProduct" GroupRef="feed9">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2 | growth factor receptor-bound protein 2" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GRB2 | growth factor receptor-bound protein 2"/>
-
     <Graphics CenterX="627.0619418035146" CenterY="149.5258571016999" Width="60.0" Height="25.0" ZOrder="33307" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="627.0619418035146" CenterY="149.5258571016999" Width="60.0" Height="25.0" ZOrder="33307" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000129946" />
+
     <Xref Database="Ensembl" ID="ENSG00000129946"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ELK1" GraphId="efd70" Type="GeneProduct" GroupRef="d89cb">
   <DataNode TextLabel="ELK1" GraphId="efd70" Type="GeneProduct" GroupRef="d89cb">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="elk-1" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="elk-1"/>
-
     <Graphics CenterX="652.1332167384685" CenterY="1009.824297231583" Width="60.0" Height="25.0" ZOrder="33318" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.1332167384685" CenterY="1009.824297231583" Width="60.0" Height="25.0" ZOrder="33318" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2002" />
+
     <Xref Database="Entrez Gene" ID="2002"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOS" GraphId="eeda2" Type="GeneProduct" GroupRef="d89cb">
   <DataNode TextLabel="FOS" GraphId="eeda2" Type="GeneProduct" GroupRef="d89cb">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FOS | v-fos FBJ murine osteosarcoma viral oncog..." />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FOS | v-fos FBJ murine osteosarcoma viral oncog..."/>
-
     <Graphics CenterX="652.1332167384685" CenterY="1038.824297231583" Width="60.0" Height="25.0" ZOrder="33322" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.1332167384685" CenterY="1038.824297231583" Width="60.0" Height="25.0" ZOrder="33322" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Entrez Gene" ID="2353" />
+
     <Xref Database="Entrez Gene" ID="2353"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CREB1" GraphId="a8039" Type="GeneProduct" GroupRef="d89cb">
   <DataNode TextLabel="CREB1" GraphId="a8039" Type="GeneProduct" GroupRef="d89cb">
-
     <Graphics CenterX="652.1332167384685" CenterY="1092.824297231583" Width="60.0" Height="25.0" ZOrder="33323" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="652.1332167384685" CenterY="1092.824297231583" Width="60.0" Height="25.0" ZOrder="33323" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000118260" />
+
     <Xref Database="Ensembl" ID="ENSG00000118260"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIK3CA" GraphId="cd8e9" Type="GeneProduct" GroupRef="ae7fb">
   <DataNode TextLabel="PIK3CA" GraphId="cd8e9" Type="GeneProduct" GroupRef="ae7fb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3ca" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3ca"/>
-
     <Graphics CenterX="842.5265238287765" CenterY="505.82763136355845" Width="60.0" Height="25.0" ZOrder="33325" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="842.5265238287765" CenterY="505.82763136355845" Width="60.0" Height="25.0" ZOrder="33325" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000121879" />
+
     <Xref Database="Ensembl" ID="ENSG00000121879"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIK3R1" GraphId="d9047" Type="GeneProduct" GroupRef="ae7fb">
   <DataNode TextLabel="PIK3R1" GraphId="d9047" Type="GeneProduct" GroupRef="ae7fb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3r1" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3r1"/>
-
     <Graphics CenterX="902.5265238287764" CenterY="505.82763136355845" Width="60.0" Height="25.0" ZOrder="33326" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="902.5265238287764" CenterY="505.82763136355845" Width="60.0" Height="25.0" ZOrder="33326" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000145675" />
+
     <Xref Database="Ensembl" ID="ENSG00000145675"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIK3R2" GraphId="b49e6" Type="GeneProduct" GroupRef="ae7fb">
   <DataNode TextLabel="PIK3R2" GraphId="b49e6" Type="GeneProduct" GroupRef="ae7fb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3r2" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3r2"/>
-
     <Graphics CenterX="902.5265238287764" CenterY="530.8276313635585" Width="60.0" Height="25.0" ZOrder="33327" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="902.5265238287764" CenterY="530.8276313635585" Width="60.0" Height="25.0" ZOrder="33327" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000105647" />
+
     <Xref Database="Ensembl" ID="ENSG00000105647"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIK3CB" GraphId="b6a56" Type="GeneProduct" GroupRef="ae7fb">
   <DataNode TextLabel="PIK3CB" GraphId="b6a56" Type="GeneProduct" GroupRef="ae7fb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3cb" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3cb"/>
-
     <Graphics CenterX="842.5265238287765" CenterY="530.8276313635585" Width="60.0" Height="25.0" ZOrder="33328" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="842.5265238287765" CenterY="530.8276313635585" Width="60.0" Height="25.0" ZOrder="33328" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000051382" />
+
     <Xref Database="Ensembl" ID="ENSG00000051382"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIK3CD" GraphId="f6f95" Type="GeneProduct" GroupRef="ae7fb">
   <DataNode TextLabel="PIK3CD" GraphId="f6f95" Type="GeneProduct" GroupRef="ae7fb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3cd" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3cd"/>
-
     <Graphics CenterX="842.5265238287765" CenterY="555.8276313635585" Width="60.0" Height="25.0" ZOrder="33329" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="842.5265238287765" CenterY="555.8276313635585" Width="60.0" Height="25.0" ZOrder="33329" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000171608" />
+
     <Xref Database="Ensembl" ID="ENSG00000171608"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIK3R3" GraphId="d440c" Type="GeneProduct" GroupRef="ae7fb">
   <DataNode TextLabel="PIK3R3" GraphId="d440c" Type="GeneProduct" GroupRef="ae7fb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3r4" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pik3r4"/>
-
     <Graphics CenterX="902.5265238287764" CenterY="555.8276313635585" Width="60.0" Height="25.0" ZOrder="33330" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="902.5265238287764" CenterY="555.8276313635585" Width="60.0" Height="25.0" ZOrder="33330" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000117461" />
+
     <Xref Database="Ensembl" ID="ENSG00000117461"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIP3" GraphId="d52f2" Type="Metabolite">
   <DataNode TextLabel="PIP3" GraphId="d52f2" Type="Metabolite">
-
     <Graphics CenterX="873.2318865997868" CenterY="634.0" Width="59.765100671140715" Height="25.0" ZOrder="33335" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="873.2318865997868" CenterY="634.0" Width="59.765100671140715" Height="25.0" ZOrder="33335" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="HMDB" ID="HMDB0004249" />
+
     <Xref Database="HMDB" ID="HMDB0004249"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="AKT1" GraphId="b9836" Type="GeneProduct" GroupRef="dddcb">
   <DataNode TextLabel="AKT1" GraphId="b9836" Type="GeneProduct" GroupRef="dddcb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt1" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt1"/>
-
     <Graphics CenterX="873.2318865997869" CenterY="701.7080000000001" Width="60.0" Height="25.0" ZOrder="33336" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="873.2318865997869" CenterY="701.7080000000001" Width="60.0" Height="25.0" ZOrder="33336" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000142208" />
+
     <Xref Database="Ensembl" ID="ENSG00000142208"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="AKT3" GraphId="f8d2e" Type="GeneProduct" GroupRef="dddcb">
   <DataNode TextLabel="AKT3" GraphId="f8d2e" Type="GeneProduct" GroupRef="dddcb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23797</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23797</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt3" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt3"/>
-
     <Graphics CenterX="873.2318865997869" CenterY="726.7080000000001" Width="60.0" Height="25.0" ZOrder="33337" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="873.2318865997869" CenterY="726.7080000000001" Width="60.0" Height="25.0" ZOrder="33337" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000117020" />
+
     <Xref Database="Ensembl" ID="ENSG00000117020"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="AKT2" GraphId="e174b" Type="GeneProduct" GroupRef="dddcb">
   <DataNode TextLabel="AKT2" GraphId="e174b" Type="GeneProduct" GroupRef="dddcb">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11652</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11652</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt2" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Akt2"/>
-
     <Graphics CenterX="873.2318865997869" CenterY="751.7080000000001" Width="60.0" Height="25.0" ZOrder="33338" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="873.2318865997869" CenterY="751.7080000000001" Width="60.0" Height="25.0" ZOrder="33338" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000105221" />
+
     <Xref Database="Ensembl" ID="ENSG00000105221"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="BAD" GraphId="e4f56" Type="GeneProduct">
   <DataNode TextLabel="BAD" GraphId="e4f56" Type="GeneProduct">
     <Comment Source="GenMAPP remarks">SOS1; son of sevenless homolog 1 (Drosophila)</Comment>
     <Comment Source="GenMAPP remarks">SOS1; son of sevenless homolog 1 (Drosophila)</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015</Comment>
-
     <Graphics CenterX="873.2318865997869" CenterY="810.8537326485321" Width="60.0" Height="25.0" ZOrder="33688" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="873.2318865997869" CenterY="810.8537326485321" Width="60.0" Height="25.0" ZOrder="33688" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000002330" />
+
     <Xref Database="Ensembl" ID="ENSG00000002330"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PTEN" GraphId="bc292" Type="GeneProduct">
   <DataNode TextLabel="PTEN" GraphId="bc292" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19211</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19211</Comment>
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pten" />
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pten"/>
-
     <Graphics CenterX="976.135753677584" CenterY="634.0" Width="60.0" Height="25.0" ZOrder="33691" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="976.135753677584" CenterY="634.0" Width="60.0" Height="25.0" ZOrder="33691" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000171862" />
+
     <Xref Database="Ensembl" ID="ENSG00000171862"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Regorafenib" GraphId="aabee" Type="Metabolite" GroupRef="d04cd">
   <DataNode TextLabel="Regorafenib" GraphId="aabee" Type="Metabolite" GroupRef="d04cd">
-
     <Graphics CenterX="529.1335350043216" CenterY="538.6274848746762" Width="79.57216940363003" Height="25.00000000000001" ZOrder="33693" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="529.1335350043216" CenterY="538.6274848746762" Width="79.57216940363003" Height="25.00000000000001" ZOrder="33693" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:68647" />
+
     <Xref Database="ChEBI" ID="CHEBI:68647"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Dabrafenib" GraphId="b487e" Type="Metabolite" GroupRef="d04cd">
   <DataNode TextLabel="Dabrafenib" GraphId="b487e" Type="Metabolite" GroupRef="d04cd">
-
     <Graphics CenterX="529.1335350043216" CenterY="481.7130509939499" Width="79.57216940363003" Height="25.00000000000001" ZOrder="33695" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="529.1335350043216" CenterY="481.7130509939499" Width="79.57216940363003" Height="25.00000000000001" ZOrder="33695" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:75045" />
+
     <Xref Database="ChEBI" ID="CHEBI:75045"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cobimetinib" GraphId="c9ac7" Type="Metabolite" GroupRef="ba758">
   <DataNode TextLabel="Cobimetinib" GraphId="c9ac7" Type="Metabolite" GroupRef="ba758">
-
     <Graphics CenterX="512.4598098530682" CenterY="687.0847018150389" Width="66.91961970613659" Height="25.0" ZOrder="33696" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="512.4598098530682" CenterY="687.0847018150389" Width="66.91961970613659" Height="25.0" ZOrder="33696" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="Wikidata" ID="Q15708292" />
+
     <Xref Database="Wikidata" ID="Q15708292"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Binimetinib" GraphId="c2af2" Type="Metabolite" GroupRef="ba758">
   <DataNode TextLabel="Binimetinib" GraphId="c2af2" Type="Metabolite" GroupRef="ba758">
-
     <Graphics CenterX="512.4598098530682" CenterY="716.0847018150389" Width="66.91961970613659" Height="25.0" ZOrder="33697" FontSize="12" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="512.4598098530682" CenterY="716.0847018150389" Width="66.91961970613659" Height="25.0" ZOrder="33697" FontSize="12" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="Wikidata" ID="Q19903515" />
+
     <Xref Database="Wikidata" ID="Q19903515"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GRIN2A" GraphId="b2160" Type="GeneProduct">
   <DataNode TextLabel="GRIN2A" GraphId="b2160" Type="GeneProduct">
-
     <Graphics CenterX="487.416814858723" CenterY="122.70341829677892" Width="54.52380952380953" Height="25.0" ZOrder="33702" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="487.416814858723" CenterY="122.70341829677892" Width="54.52380952380953" Height="25.0" ZOrder="33702" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000183454" />
+
     <Xref Database="Ensembl" ID="ENSG00000183454"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CALM1" GraphId="e00f6" Type="GeneProduct" GroupRef="a1796">
   <DataNode TextLabel="CALM1" GraphId="e00f6" Type="GeneProduct" GroupRef="a1796">
-
     <Graphics CenterX="459.9303497332546" CenterY="204.38865836791166" Width="54.52380952380953" Height="25.0" ZOrder="33705" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="459.9303497332546" CenterY="204.38865836791166" Width="54.52380952380953" Height="25.0" ZOrder="33705" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000198668" />
+
     <Xref Database="Ensembl" ID="ENSG00000198668"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CALM2" GraphId="a501a" Type="GeneProduct" GroupRef="a1796">
   <DataNode TextLabel="CALM2" GraphId="a501a" Type="GeneProduct" GroupRef="a1796">
-
     <Graphics CenterX="459.9303497332546" CenterY="229.3886583679116" Width="54.52380952380953" Height="25.0" ZOrder="33706" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="459.9303497332546" CenterY="229.3886583679116" Width="54.52380952380953" Height="25.0" ZOrder="33706" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000143933" />
+
     <Xref Database="Ensembl" ID="ENSG00000143933"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CALM3" GraphId="b6b34" Type="GeneProduct" GroupRef="a1796">
   <DataNode TextLabel="CALM3" GraphId="b6b34" Type="GeneProduct" GroupRef="a1796">
-
     <Graphics CenterX="459.9303497332546" CenterY="254.38865836791138" Width="54.52380952380953" Height="25.0" ZOrder="33707" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="459.9303497332546" CenterY="254.38865836791138" Width="54.52380952380953" Height="25.0" ZOrder="33707" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000160014" />
+
     <Xref Database="Ensembl" ID="ENSG00000160014"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CALML3" GraphId="f4e40" Type="GeneProduct" GroupRef="a1796">
   <DataNode TextLabel="CALML3" GraphId="f4e40" Type="GeneProduct" GroupRef="a1796">
-
     <Graphics CenterX="514.6922544951591" CenterY="197.24580122505432" Width="54.52380952380953" Height="25.0" ZOrder="33708" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="514.6922544951591" CenterY="197.24580122505432" Width="54.52380952380953" Height="25.0" ZOrder="33708" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000178363" />
+
     <Xref Database="Ensembl" ID="ENSG00000178363"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CALML4" GraphId="edda9" Type="GeneProduct" GroupRef="a1796">
   <DataNode TextLabel="CALML4" GraphId="edda9" Type="GeneProduct" GroupRef="a1796">
-
     <Graphics CenterX="514.6922544951591" CenterY="222.24580122505432" Width="54.52380952380953" Height="25.0" ZOrder="33709" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="514.6922544951591" CenterY="222.24580122505432" Width="54.52380952380953" Height="25.0" ZOrder="33709" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000129007" />
+
     <Xref Database="Ensembl" ID="ENSG00000129007"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CALML5" GraphId="be21c" Type="GeneProduct" GroupRef="a1796">
   <DataNode TextLabel="CALML5" GraphId="be21c" Type="GeneProduct" GroupRef="a1796">
-
     <Graphics CenterX="514.6922544951591" CenterY="247.24580122505427" Width="54.52380952380953" Height="25.0" ZOrder="33710" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="514.6922544951591" CenterY="247.24580122505427" Width="54.52380952380953" Height="25.0" ZOrder="33710" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000178372" />
+
     <Xref Database="Ensembl" ID="ENSG00000178372"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CALML6" GraphId="d2490" Type="GeneProduct" GroupRef="a1796">
   <DataNode TextLabel="CALML6" GraphId="d2490" Type="GeneProduct" GroupRef="a1796">
-
     <Graphics CenterX="514.6922544951591" CenterY="272.2458012250538" Width="54.52380952380953" Height="25.0" ZOrder="33711" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="514.6922544951591" CenterY="272.2458012250538" Width="54.52380952380953" Height="25.0" ZOrder="33711" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000169885" />
+
     <Xref Database="Ensembl" ID="ENSG00000169885"/>
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Regulation of &#xA;Actin Cytoskeleton" GraphId="ad8c2" Type="Pathway">
+
   <DataNode TextLabel="Regulation of &#10;Actin Cytoskeleton" GraphId="ad8c2" Type="Pathway">
-
     <Graphics CenterX="149.0714285714286" CenterY="432.8452380952381" Width="116.90476190476181" Height="33.928571428571445" ZOrder="33712" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" />
+
     <Graphics CenterX="149.0714285714286" CenterY="432.8452380952381" Width="116.90476190476181" Height="33.928571428571445" ZOrder="33712" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e"/>
-
     <Xref Database="WikiPathways" ID="WP51" />
+
     <Xref Database="WikiPathways" ID="WP51"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TP53" GraphId="b2dcb" Type="GeneProduct">
   <DataNode TextLabel="TP53" GraphId="b2dcb" Type="GeneProduct">
-
     <Graphics CenterX="221.37895538787905" CenterY="913.6775850005804" Width="71.0" Height="25.0" ZOrder="33719" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="221.37895538787905" CenterY="913.6775850005804" Width="71.0" Height="25.0" ZOrder="33719" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000141510" />
+
     <Xref Database="Ensembl" ID="ENSG00000141510"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CDKN1A" GraphId="f2f2f" Type="GeneProduct" GroupRef="d4179">
   <DataNode TextLabel="CDKN1A" GraphId="f2f2f" Type="GeneProduct" GroupRef="d4179">
-
     <Graphics CenterX="298.04562205454545" CenterY="971.8442516672478" Width="71.0" Height="25.0" ZOrder="33721" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="298.04562205454545" CenterY="971.8442516672478" Width="71.0" Height="25.0" ZOrder="33721" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000124762" />
+
     <Xref Database="Ensembl" ID="ENSG00000124762"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="BAX" GraphId="f0a19" Type="GeneProduct" GroupRef="d4179">
   <DataNode TextLabel="BAX" GraphId="f0a19" Type="GeneProduct" GroupRef="d4179">
-
     <Graphics CenterX="298.04562205454545" CenterY="999.5109183339143" Width="48.607843137255145" Height="25.0" ZOrder="33722" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="298.04562205454545" CenterY="999.5109183339143" Width="48.607843137255145" Height="25.0" ZOrder="33722" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000087088" />
+
     <Xref Database="Ensembl" ID="ENSG00000087088"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DDB2" GraphId="db220" Type="GeneProduct" GroupRef="d4179">
   <DataNode TextLabel="DDB2" GraphId="db220" Type="GeneProduct" GroupRef="d4179">
-
     <Graphics CenterX="298.04562205454545" CenterY="1027.1775850005815" Width="48.607843137255145" Height="25.0" ZOrder="33723" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="298.04562205454545" CenterY="1027.1775850005815" Width="48.607843137255145" Height="25.0" ZOrder="33723" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000134574" />
+
     <Xref Database="Ensembl" ID="ENSG00000134574"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="POLK" GraphId="e3cdc" Type="GeneProduct" GroupRef="d4179">
   <DataNode TextLabel="POLK" GraphId="e3cdc" Type="GeneProduct" GroupRef="d4179">
-
     <Graphics CenterX="351.5750338192522" CenterY="1026.510918333915" Width="49.27450980392223" Height="25.0" ZOrder="33724" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="351.5750338192522" CenterY="1026.510918333915" Width="49.27450980392223" Height="25.0" ZOrder="33724" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000122008" />
+
     <Xref Database="Ensembl" ID="ENSG00000122008"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="BAK1" GraphId="fd1fd" Type="GeneProduct" GroupRef="d4179">
   <DataNode TextLabel="BAK1" GraphId="fd1fd" Type="GeneProduct" GroupRef="d4179">
-
     <Graphics CenterX="351.5750338192522" CenterY="999.1775850005818" Width="49.27450980392223" Height="25.0" ZOrder="33725" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="351.5750338192522" CenterY="999.1775850005818" Width="49.27450980392223" Height="25.0" ZOrder="33725" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000030110" />
+
     <Xref Database="Ensembl" ID="ENSG00000030110"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GADD45G" GraphId="fcdfd" Type="GeneProduct" GroupRef="d4179">
   <DataNode TextLabel="GADD45G" GraphId="fcdfd" Type="GeneProduct" GroupRef="d4179">
-
     <Graphics CenterX="416.71228872121264" CenterY="979.8442516672485" Width="71.0" Height="25.0" ZOrder="33726" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="416.71228872121264" CenterY="979.8442516672485" Width="71.0" Height="25.0" ZOrder="33726" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000130222" />
+
     <Xref Database="Ensembl" ID="ENSG00000130222"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GADD45A" GraphId="f19a9" Type="GeneProduct" GroupRef="d4179">
   <DataNode TextLabel="GADD45A" GraphId="f19a9" Type="GeneProduct" GroupRef="d4179">
-
     <Graphics CenterX="416.71228872121264" CenterY="1004.8442516672485" Width="71.0" Height="25.0" ZOrder="33727" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="416.71228872121264" CenterY="1004.8442516672485" Width="71.0" Height="25.0" ZOrder="33727" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000116717" />
+
     <Xref Database="Ensembl" ID="ENSG00000116717"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GADD45B" GraphId="fffaf" Type="GeneProduct" GroupRef="d4179">
   <DataNode TextLabel="GADD45B" GraphId="fffaf" Type="GeneProduct" GroupRef="d4179">
-
     <Graphics CenterX="416.71228872121264" CenterY="1029.844251667249" Width="71.0" Height="25.0" ZOrder="33728" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="416.71228872121264" CenterY="1029.844251667249" Width="71.0" Height="25.0" ZOrder="33728" FontSize="12" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000099860" />
+
     <Xref Database="Ensembl" ID="ENSG00000099860"/>
   </DataNode>
   </DataNode>
   <State GraphRef="b62ea" TextLabel="P" GraphId="d04da">
   <State GraphRef="b62ea" TextLabel="P" GraphId="d04da">
-
     <Graphics RelX="1.0" RelY="-0.76" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="1.0" RelY="-0.76" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="a4836" TextLabel="" GraphId="ae31d">
   <State GraphRef="a4836" TextLabel="" GraphId="ae31d">
-
     <Graphics RelX="-1.0" RelY="-0.9621052631578959" Width="15.0" Height="15.0" ShapeType="Triangle" />
+
     <Graphics RelX="-1.0" RelY="-0.9621052631578959" Width="15.0" Height="15.0" ShapeType="Triangle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="a4836" TextLabel="P" GraphId="b7114">
   <State GraphRef="a4836" TextLabel="P" GraphId="b7114">
-
     <Graphics RelX="1.0" RelY="-0.92" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="1.0" RelY="-0.92" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="c882f" TextLabel="+" GraphId="a9c90">
   <State GraphRef="c882f" TextLabel="+" GraphId="a9c90">
-
     <Graphics RelX="-0.9906103286385043" RelY="-0.7523809523809529" Width="15.0" Height="15.0" />
+
     <Graphics RelX="-0.9906103286385043" RelY="-0.7523809523809529" Width="15.0" Height="15.0"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="dadaf" TextLabel="" GraphId="b2d49">
   <State GraphRef="dadaf" TextLabel="" GraphId="b2d49">
-
     <Graphics RelX="-0.9117647058823529" RelY="-0.76" Width="15.0" Height="15.0" ShapeType="Triangle" />
+
     <Graphics RelX="-0.9117647058823529" RelY="-0.76" Width="15.0" Height="15.0" ShapeType="Triangle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="c1a2a" TextLabel="" GraphId="bf5c6">
   <State GraphRef="c1a2a" TextLabel="" GraphId="bf5c6">
-
     <Graphics RelX="-0.9701492537313433" RelY="-0.92" Width="15.0" Height="15.0" ShapeType="Triangle" />
+
     <Graphics RelX="-0.9701492537313433" RelY="-0.92" Width="15.0" Height="15.0" ShapeType="Triangle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="da366" TextLabel="" GraphId="d15c1">
   <State GraphRef="da366" TextLabel="" GraphId="d15c1">
-
     <Graphics RelX="-0.9555555555555556" RelY="-0.76" Width="15.0" Height="15.0" ShapeType="Triangle" />
+
     <Graphics RelX="-0.9555555555555556" RelY="-0.76" Width="15.0" Height="15.0" ShapeType="Triangle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="a83c8" TextLabel="" GraphId="d4bc5">
   <State GraphRef="a83c8" TextLabel="" GraphId="d4bc5">
-
     <Graphics RelX="-1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Hexagon" />
+
     <Graphics RelX="-1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Hexagon"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="a5e54" TextLabel="" GraphId="def55">
   <State GraphRef="a5e54" TextLabel="" GraphId="def55">
-
     <Graphics RelX="-0.9999999999999984" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Triangle" />
+
     <Graphics RelX="-0.9999999999999984" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Triangle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="c4c5c" TextLabel="+" GraphId="ee802">
   <State GraphRef="c4c5c" TextLabel="+" GraphId="ee802">
-
     <Graphics RelX="-0.9299610894941607" RelY="-0.7523809523809541" Width="15.0" Height="15.0" />
+
     <Graphics RelX="-0.9299610894941607" RelY="-0.7523809523809541" Width="15.0" Height="15.0"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="d0958" TextLabel="" GraphId="ff2da">
   <State GraphRef="d0958" TextLabel="" GraphId="ff2da">
-
     <Graphics RelX="-1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Triangle" />
+
     <Graphics RelX="-1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Triangle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="d2061" TextLabel="P" GraphId="ad173">
   <State GraphRef="d2061" TextLabel="P" GraphId="ad173">
-
     <Graphics RelX="0.9734892787524358" RelY="-0.49426900584795475" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.9734892787524358" RelY="-0.49426900584795475" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="add26" TextLabel="" GraphId="a7f1d">
   <State GraphRef="add26" TextLabel="" GraphId="a7f1d">
     <Comment>V600E</Comment>
     <Comment>V600E</Comment>
-
     <Graphics RelX="-0.8978557504873304" RelY="-0.7749707602339367" Width="15.0" Height="15.0" ShapeType="Triangle" />
+
     <Graphics RelX="-0.8978557504873304" RelY="-0.7749707602339367" Width="15.0" Height="15.0" ShapeType="Triangle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="de9ef" TextLabel="P" GraphId="c5c47">
   <State GraphRef="de9ef" TextLabel="P" GraphId="c5c47">
-
     <Comment></Comment>
+
     <Comment/>
-
     <Graphics RelX="0.9220272904483409" RelY="-0.7749707602339458" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.9220272904483409" RelY="-0.7749707602339458" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="de9ef" TextLabel="P" GraphId="fc882">
   <State GraphRef="de9ef" TextLabel="P" GraphId="fc882">
     <Comment>parent=P04049; parentsymbol=RAF1; site=IGDFGLAtVksRWsG; position=thr491; sitegrpid=447748; ptm=p; direction=u</Comment>
     <Comment>parent=P04049; parentsymbol=RAF1; site=IGDFGLAtVksRWsG; position=thr491; sitegrpid=447748; ptm=p; direction=u</Comment>
-
     <Graphics RelX="0.9734892787524358" RelY="0.5349707602339276" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.9734892787524358" RelY="0.5349707602339276" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="fb416" TextLabel="P" GraphId="a85ad">
   <State GraphRef="fb416" TextLabel="P" GraphId="a85ad">
     <Comment>parent=Q02750; parentsymbol=MAP2K1; site=LIDsMANsFVGTRSY; position=ser222; sitegrpid=448513; ptm=p; direction=u</Comment>
     <Comment>parent=Q02750; parentsymbol=MAP2K1; site=LIDsMANsFVGTRSY; position=ser222; sitegrpid=448513; ptm=p; direction=u</Comment>
-
     <Graphics RelX="0.9345029239766063" RelY="-0.7749707602339094" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.9345029239766063" RelY="-0.7749707602339094" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="fb416" TextLabel="P" GraphId="b8a7f">
   <State GraphRef="fb416" TextLabel="P" GraphId="b8a7f">
     <Comment>parent=Q02750; parentsymbol=MAP2K1; site=VsGQLIDsMANsFVG; position=ser218; sitegrpid=448514; ptm=p; direction=u</Comment>
     <Comment>parent=Q02750; parentsymbol=MAP2K1; site=VsGQLIDsMANsFVG; position=ser218; sitegrpid=448514; ptm=p; direction=u</Comment>
-
     <Graphics RelX="-0.8588693957115008" RelY="-0.6814035087719276" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="-0.8588693957115008" RelY="-0.6814035087719276" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="dd167" TextLabel="P" GraphId="ac2f1">
   <State GraphRef="dd167" TextLabel="P" GraphId="ac2f1">
     <Comment>parent=P28482; parentsymbol=MAPK1; site=HtGFLtEyVAtRWyR; position=tyr187; sitegrpid=447594; ptm=p; direction=u</Comment>
     <Comment>parent=P28482; parentsymbol=MAPK1; site=HtGFLtEyVAtRWyR; position=tyr187; sitegrpid=447594; ptm=p; direction=u</Comment>
-
     <Graphics RelX="0.856530214424951" RelY="-0.7749707602339185" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.856530214424951" RelY="-0.7749707602339185" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="dd167" TextLabel="P" GraphId="f8890">
   <State GraphRef="dd167" TextLabel="P" GraphId="f8890">
     <Comment>parent=P28482; parentsymbol=MAPK1; site=HDHtGFLtEyVAtRW; position=thr185; sitegrpid=447593; ptm=p; direction=u</Comment>
     <Comment>parent=P28482; parentsymbol=MAPK1; site=HDHtGFLtEyVAtRW; position=thr185; sitegrpid=447593; ptm=p; direction=u</Comment>
-
     <Graphics RelX="-0.8588693957115008" RelY="-0.7749707602339185" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="-0.8588693957115008" RelY="-0.7749707602339185" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="e98e0" TextLabel="P" GraphId="c0282">
   <State GraphRef="e98e0" TextLabel="P" GraphId="c0282">
     <Comment>parent=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; sitegrpid=447542; ptm=p; direction=u</Comment>
     <Comment>parent=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; sitegrpid=447542; ptm=p; direction=u</Comment>
-
     <Graphics RelX="0.856530214424951" RelY="-0.7749707602339185" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.856530214424951" RelY="-0.7749707602339185" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="e98e0" TextLabel="P" GraphId="e4279">
   <State GraphRef="e98e0" TextLabel="P" GraphId="e4279">
     <Comment>parent=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyR; position=tyr204; sitegrpid=447543; ptm=p; direction=u</Comment>
     <Comment>parent=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyR; position=tyr204; sitegrpid=447543; ptm=p; direction=u</Comment>
-
     <Graphics RelX="-0.819883040935675" RelY="-0.7749707602339185" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="-0.819883040935675" RelY="-0.7749707602339185" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="b2cfe" TextLabel="P" GraphId="a2300">
   <State GraphRef="b2cfe" TextLabel="P" GraphId="a2300">
     <Comment>parent=P36507; parentsymbol=MAP2K2; site=LIDsMANsFVGTRSY; position=ser226; sitegrpid=448074; ptm=p; direction=u</Comment>
     <Comment>parent=P36507; parentsymbol=MAP2K2; site=LIDsMANsFVGTRSY; position=ser226; sitegrpid=448074; ptm=p; direction=u</Comment>
-
     <Graphics RelX="0.9345029239766063" RelY="-0.6814035087719276" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.9345029239766063" RelY="-0.6814035087719276" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="b2cfe" TextLabel="P" GraphId="bfa0a">
   <State GraphRef="b2cfe" TextLabel="P" GraphId="bfa0a">
     <Comment>parent=P36507; parentsymbol=MAP2K2; site=VsGQLIDsMANsFVG; position=ser222; sitegrpid=448073; ptm=p; direction=u</Comment>
     <Comment>parent=P36507; parentsymbol=MAP2K2; site=VsGQLIDsMANsFVG; position=ser222; sitegrpid=448073; ptm=p; direction=u</Comment>
-
     <Graphics RelX="-0.8050682261208597" RelY="-0.7749707602339094" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="-0.8050682261208597" RelY="-0.7749707602339094" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="efd70" TextLabel="P" GraphId="b496d">
   <State GraphRef="efd70" TextLabel="P" GraphId="b496d">
     <Comment>parent=P19419; position=ser324; ptm=p; direction=u</Comment>
     <Comment>parent=P19419; position=ser324; ptm=p; direction=u</Comment>
-
     <Graphics RelX="0.9610136452241742" RelY="-0.8713450292397646" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.9610136452241742" RelY="-0.8713450292397646" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="efd70" TextLabel="P" GraphId="eac3b">
   <State GraphRef="efd70" TextLabel="P" GraphId="eac3b">
     <Comment>parent=P19419; position=ser389; ptm=p; direction=u</Comment>
     <Comment>parent=P19419; position=ser389; ptm=p; direction=u</Comment>
-
     <Graphics RelX="-1.0" RelY="-0.9064327485380181" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="-1.0" RelY="-0.9064327485380181" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="efd70" TextLabel="P" GraphId="fe098">
   <State GraphRef="efd70" TextLabel="P" GraphId="fe098">
     <Comment>parent=P19419; position=ser383; ptm=p; direction=u</Comment>
     <Comment>parent=P19419; position=ser383; ptm=p; direction=u</Comment>
-
     <Graphics RelX="0.9345029239766063" RelY="0.8128654970760181" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="0.9345029239766063" RelY="0.8128654970760181" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="e4f56" TextLabel="P" GraphId="b1e93">
   <State GraphRef="e4f56" TextLabel="P" GraphId="b1e93">
     <Comment>parent=Q92934; position=ser75; ptm=p; direction=d</Comment>
     <Comment>parent=Q92934; position=ser75; ptm=p; direction=d</Comment>
-
     <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval" />
+
     <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="bc292" TextLabel="" GraphId="d43b9">
   <State GraphRef="bc292" TextLabel="" GraphId="d43b9">
-
     <Graphics RelX="-0.9302794583693602" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Hexagon" />
+
     <Graphics RelX="-0.9302794583693602" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Hexagon"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="b2160" TextLabel="" GraphId="a75c9">
   <State GraphRef="b2160" TextLabel="" GraphId="a75c9">
-
     <Graphics RelX="-1.0" RelY="-0.92" Width="15.0" Height="15.0" ShapeType="Triangle" />
+
     <Graphics RelX="-1.0" RelY="-0.92" Width="15.0" Height="15.0" ShapeType="Triangle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <State GraphRef="b2dcb" TextLabel="" GraphId="ae69d">
   <State GraphRef="b2dcb" TextLabel="" GraphId="ae69d">
-
     <Graphics RelX="-1.0" RelY="-0.84" Width="15.0" Height="15.0" ShapeType="Hexagon" />
+
     <Graphics RelX="-1.0" RelY="-0.84" Width="15.0" Height="15.0" ShapeType="Hexagon"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </State>
   </State>
   <Interaction GraphId="id3038f90d">
   <Interaction GraphId="id3038f90d">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="553.9196197061365" Y="701.5847018150389" GraphRef="d6e9c" RelX="1.0" RelY="0.0" />
+
       <Point X="553.9196197061365" Y="701.5847018150389" GraphRef="d6e9c" RelX="1.0" RelY="0.0"/>
-
       <Point X="622.3333333333333" Y="701.588677888971" GraphRef="b2cfe" RelX="-1.0" RelY="0.0" ArrowHead="mim-inhibition" />
+
       <Point X="622.3333333333333" Y="701.588677888971" GraphRef="b2cfe" RelX="-1.0" RelY="0.0" ArrowHead="mim-inhibition"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id60521044">
   <Interaction GraphId="id60521044">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="193.16666666666663" Y="349.35714285714266" GraphRef="ee2b4" RelX="0.0" RelY="1.0" />
+
       <Point X="193.16666666666663" Y="349.35714285714266" GraphRef="ee2b4" RelX="0.0" RelY="1.0"/>
-
       <Point X="252.2857142857144" Y="424.9285714285715" GraphRef="bf79d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="252.2857142857144" Y="424.9285714285715" GraphRef="bf79d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id658d81f7">
   <Interaction GraphId="id658d81f7">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="652.3333333333334" Y="599.088677888971" GraphRef="cec9d" RelX="0.0" RelY="1.0" />
+
       <Point X="652.3333333333334" Y="599.088677888971" GraphRef="cec9d" RelX="0.0" RelY="1.0"/>
-
       <Point X="652.3333333333333" Y="656.088677888971" GraphRef="c5812" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="652.3333333333333" Y="656.088677888971" GraphRef="c5812" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id67b2dffe">
   <Interaction GraphId="id67b2dffe">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="193.16666666666663" Y="135.64285714285728" GraphRef="af675" RelX="0.0" RelY="1.0" />
+
       <Point X="193.16666666666663" Y="135.64285714285728" GraphRef="af675" RelX="0.0" RelY="1.0"/>
-
       <Point X="193.16666666666663" Y="231.35714285714266" GraphRef="c1a2a" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="193.16666666666663" Y="231.35714285714266" GraphRef="c1a2a" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id6873447b">
   <Interaction GraphId="id6873447b">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="946.135753677584" Y="634.0" GraphRef="bc292" RelX="-1.0" RelY="0.0" />
+
       <Point X="946.135753677584" Y="634.0" GraphRef="bc292" RelX="-1.0" RelY="0.0"/>
-
       <Point X="903.1144369353572" Y="634.0" GraphRef="d52f2" RelX="1.0" RelY="0.0" ArrowHead="mim-inhibition" />
+
       <Point X="903.1144369353572" Y="634.0" GraphRef="d52f2" RelX="1.0" RelY="0.0" ArrowHead="mim-inhibition"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id6f130a55">
   <Interaction GraphId="id6f130a55">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="176.41666666666663" Y="256.35714285714266" GraphRef="c1a2a" RelX="-0.5" RelY="1.0" />
+
       <Point X="176.41666666666663" Y="256.35714285714266" GraphRef="c1a2a" RelX="-0.5" RelY="1.0"/>
-
       <Point X="140.0238095238096" Y="283.02380952380975" GraphRef="b5476" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="140.0238095238096" Y="283.02380952380975" GraphRef="b5476" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id76b7601e">
   <Interaction GraphId="id76b7601e">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="651.8804379141453" Y="250.50734658599873" GraphRef="e1fd3" RelX="0.0" RelY="1.0" />
+
       <Point X="651.8804379141453" Y="250.50734658599873" GraphRef="e1fd3" RelX="0.0" RelY="1.0"/>
-
       <Point X="652.0" Y="358.287557440792" GraphRef="b86f8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="652.0" Y="358.287557440792" GraphRef="b86f8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id7ac4f96">
   <Interaction GraphId="id7ac4f96">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="687.4285714285713" Y="302.1666666666665" GraphRef="dadaf" RelX="0.0" RelY="1.0" />
+
       <Point X="687.4285714285713" Y="302.1666666666665" GraphRef="dadaf" RelX="0.0" RelY="1.0"/>
-
       <Point X="671.0" Y="358.287557440792" GraphRef="b86f8" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="671.0" Y="358.287557440792" GraphRef="b86f8" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id7db2c6ed">
   <Interaction GraphId="id7db2c6ed">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="487.416814858723" Y="135.20341829677892" GraphRef="b2160" RelX="0.0" RelY="1.0" />
+
       <Point X="487.416814858723" Y="135.20341829677892" GraphRef="b2160" RelX="0.0" RelY="1.0"/>
-
       <Point X="487.3113021142069" Y="176.74580122505432" GraphRef="e48a0" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="487.3113021142069" Y="176.74580122505432" GraphRef="e48a0" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="id89ff29eb">
   <Interaction GraphId="id89ff29eb">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="721.0" Y="403.0" GraphRef="a83c8" RelX="-1.0" RelY="0.0" />
+
       <Point X="721.0" Y="403.0" GraphRef="a83c8" RelX="-1.0" RelY="0.0"/>
-
       <Point X="690.0" Y="403.787557440792" GraphRef="b86f8" RelX="1.0" RelY="0.0" ArrowHead="TBar" />
+
       <Point X="690.0" Y="403.787557440792" GraphRef="b86f8" RelX="1.0" RelY="0.0" ArrowHead="TBar"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="ida7259264">
   <Interaction GraphId="ida7259264">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
-
       <Point X="671.0" Y="449.287557440792" GraphRef="b86f8" RelX="0.5" RelY="1.0" />
+
       <Point X="671.0" Y="449.287557440792" GraphRef="b86f8" RelX="0.5" RelY="1.0"/>
-
       <Point X="838.5265238287764" Y="485.32763136355845" GraphRef="bdc0d" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="838.5265238287764" Y="485.32763136355845" GraphRef="bdc0d" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idb067a48f">
   <Interaction GraphId="idb067a48f">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="872.5265238287764" Y="576.3276313635585" GraphRef="bdc0d" RelX="0.0" RelY="1.0" />
+
       <Point X="872.5265238287764" Y="576.3276313635585" GraphRef="bdc0d" RelX="0.0" RelY="1.0"/>
-
       <Point X="873.2318865997868" Y="621.5" GraphRef="d52f2" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="873.2318865997868" Y="621.5" GraphRef="d52f2" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idb11acdaf">
   <Interaction GraphId="idb11acdaf">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
-
       <Point X="335.07142857142867" Y="137.3095238095238" GraphRef="a5e54" RelX="0.0" RelY="1.0" />
+
       <Point X="335.07142857142867" Y="137.3095238095238" GraphRef="a5e54" RelX="0.0" RelY="1.0"/>
-
       <Point X="484.20238095238096" Y="612.0" />
+
       <Point X="484.20238095238096" Y="612.0"/>
-
       <Point X="633.3333333333333" Y="656.088677888971" GraphRef="c5812" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="633.3333333333333" Y="656.088677888971" GraphRef="c5812" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idc902fd3b">
   <Interaction GraphId="idc902fd3b">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="970.1190476190476" Y="134.59523809523813" GraphRef="c882f" RelX="0.0" RelY="1.0" />
+
       <Point X="970.1190476190476" Y="134.59523809523813" GraphRef="c882f" RelX="0.0" RelY="1.0"/>
-
       <Point X="872.5265238287764" Y="485.32763136355845" ArrowHead="Arrow" />
+
       <Point X="872.5265238287764" Y="485.32763136355845" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="ide93c2ede">
   <Interaction GraphId="ide93c2ede">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="1052.0" Y="634.0" GraphRef="da366" RelX="-1.0" RelY="0.0" />
+
       <Point X="1052.0" Y="634.0" GraphRef="da366" RelX="-1.0" RelY="0.0"/>
-
       <Point X="1006.135753677584" Y="634.0" GraphRef="bc292" RelX="1.0" RelY="0.0" ArrowHead="mim-inhibition" />
+
       <Point X="1006.135753677584" Y="634.0" GraphRef="bc292" RelX="1.0" RelY="0.0" ArrowHead="mim-inhibition"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idf539d9b9">
   <Interaction GraphId="idf539d9b9">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="487.3113021142069" Y="292.7458012250538" GraphRef="e48a0" RelX="0.0" RelY="1.0" />
+
       <Point X="487.3113021142069" Y="292.7458012250538" GraphRef="e48a0" RelX="0.0" RelY="1.0"/>
-
       <Point X="633.0" Y="358.287557440792" GraphRef="b86f8" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="633.0" Y="358.287557440792" GraphRef="b86f8" RelX="-0.5" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idf7fa0bea">
   <Interaction GraphId="idf7fa0bea">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="576.9196197061367" Y="524.3988764044943" GraphRef="aa385" RelX="1.0" RelY="0.0" />
+
       <Point X="576.9196197061367" Y="524.3988764044943" GraphRef="aa385" RelX="1.0" RelY="0.0"/>
-
       <Point X="622.3333333333334" Y="524.588677888971" GraphRef="add26" RelX="-1.0" RelY="0.0" ArrowHead="mim-inhibition" />
+
       <Point X="622.3333333333334" Y="524.588677888971" GraphRef="add26" RelX="-1.0" RelY="0.0" ArrowHead="mim-inhibition"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idf7fc043e">
   <Interaction GraphId="idf7fc043e">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="1102.547619047619" Y="136.59523809523813" GraphRef="d0958" RelX="0.0" RelY="1.0" />
+
       <Point X="1102.547619047619" Y="136.59523809523813" GraphRef="d0958" RelX="0.0" RelY="1.0"/>
-
       <Point X="906.5265238287764" Y="485.32763136355845" GraphRef="bdc0d" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="906.5265238287764" Y="485.32763136355845" GraphRef="bdc0d" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idf99f6e0b">
   <Interaction GraphId="idf99f6e0b">
     <Graphics ZOrder="12288" LineThickness="1.0">
     <Graphics ZOrder="12288" LineThickness="1.0">
-
       <Point X="193.16666666666663" Y="256.35714285714266" GraphRef="c1a2a" RelX="0.0" RelY="1.0" />
+
       <Point X="193.16666666666663" Y="256.35714285714266" GraphRef="c1a2a" RelX="0.0" RelY="1.0"/>
-
       <Point X="193.16666666666663" Y="324.35714285714266" GraphRef="ee2b4" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="193.16666666666663" Y="324.35714285714266" GraphRef="ee2b4" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="idfb801940">
   <Interaction GraphId="idfb801940">
     <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
     <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
-
       <Point X="852.4999999999998" Y="134.59523809523813" GraphRef="c4c5c" RelX="0.0" RelY="1.0" />
+
       <Point X="852.4999999999998" Y="134.59523809523813" GraphRef="c4c5c" RelX="0.0" RelY="1.0"/>
-
       <Point X="671.0" Y="358.287557440792" GraphRef="b86f8" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="671.0" Y="358.287557440792" GraphRef="b86f8" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="bb4c3">
   <Interaction GraphId="bb4c3">
     <Graphics ZOrder="33269" LineThickness="1.0">
     <Graphics ZOrder="33269" LineThickness="1.0">
-
       <Point X="652.0" Y="449.287557440792" GraphRef="b86f8" RelX="0.0" RelY="1.0" />
+
       <Point X="652.0" Y="449.287557440792" GraphRef="b86f8" RelX="0.0" RelY="1.0"/>
-
       <Point X="652.3333333333334" Y="500.088677888971" GraphRef="cec9d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="652.3333333333334" Y="500.088677888971" GraphRef="cec9d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="c2103">
   <Interaction GraphId="c2103">
     <Graphics ZOrder="33294" LineThickness="1.0">
     <Graphics ZOrder="33294" LineThickness="1.0">
-
       <Point X="652.3333333333333" Y="722.088677888971" GraphRef="c5812" RelX="0.0" RelY="1.0" />
+
       <Point X="652.3333333333333" Y="722.088677888971" GraphRef="c5812" RelX="0.0" RelY="1.0"/>
-
       <Point X="652.2338935574229" Y="759.2287339113802" GraphRef="f6d68" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="652.2338935574229" Y="759.2287339113802" GraphRef="f6d68" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="bafaf">
   <Interaction GraphId="bafaf">
     <Graphics ZOrder="33309" LineThickness="1.0">
     <Graphics ZOrder="33309" LineThickness="1.0">
-
       <Point X="652.2338935574229" Y="825.2287339113802" GraphRef="f6d68" RelX="0.0" RelY="1.0" />
+
       <Point X="652.2338935574229" Y="825.2287339113802" GraphRef="f6d68" RelX="0.0" RelY="1.0"/>
-
       <Point X="652.1332167384685" Y="989.3242972315829" GraphRef="b9d21" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="652.1332167384685" Y="989.3242972315829" GraphRef="b9d21" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="f40c1">
   <Interaction GraphId="f40c1">
     <Graphics ZOrder="33313" LineStyle="Broken" LineThickness="1.0">
     <Graphics ZOrder="33313" LineStyle="Broken" LineThickness="1.0">
-
       <Point X="652.1332167384685" Y="1113.324297231583" GraphRef="b9d21" RelX="0.0" RelY="1.0" />
+
       <Point X="652.1332167384685" Y="1113.324297231583" GraphRef="b9d21" RelX="0.0" RelY="1.0"/>
-
       <Point X="651.4999999999999" Y="1143.6106442577034" GraphRef="eb9ba" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="651.4999999999999" Y="1143.6106442577034" GraphRef="eb9ba" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="c43e0">
   <Interaction GraphId="c43e0">
     <Graphics ZOrder="33333" LineThickness="1.0">
     <Graphics ZOrder="33333" LineThickness="1.0">
-
       <Point X="873.2318865997868" Y="646.5" GraphRef="d52f2" RelX="0.0" RelY="1.0" />
+
       <Point X="873.2318865997868" Y="646.5" GraphRef="d52f2" RelX="0.0" RelY="1.0"/>
-
       <Point X="873.2318865997869" Y="681.2080000000001" GraphRef="e24c8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="873.2318865997869" Y="681.2080000000001" GraphRef="e24c8" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="c07d2">
   <Interaction GraphId="c07d2">
     <Graphics ZOrder="33686" LineStyle="Broken" LineThickness="1.0">
     <Graphics ZOrder="33686" LineStyle="Broken" LineThickness="1.0">
-
       <Point X="873.2318865997869" Y="823.3537326485321" GraphRef="e4f56" RelX="0.0" RelY="1.0" />
+
       <Point X="873.2318865997869" Y="823.3537326485321" GraphRef="e4f56" RelX="0.0" RelY="1.0"/>
-
       <Point X="873.2318865997869" Y="1046.3225871000736" GraphRef="fa101" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="873.2318865997869" Y="1046.3225871000736" GraphRef="fa101" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="a3573">
   <Interaction GraphId="a3573">
     <Graphics ZOrder="33687" LineThickness="1.0">
     <Graphics ZOrder="33687" LineThickness="1.0">
-
       <Point X="873.2318865997869" Y="772.2080000000001" GraphRef="e24c8" RelX="0.0" RelY="1.0" />
+
       <Point X="873.2318865997869" Y="772.2080000000001" GraphRef="e24c8" RelX="0.0" RelY="1.0"/>
-
       <Point X="873.2318865997869" Y="798.3537326485321" GraphRef="e4f56" RelX="0.0" RelY="-1.0" ArrowHead="TBar" />
+
       <Point X="873.2318865997869" Y="798.3537326485321" GraphRef="e4f56" RelX="0.0" RelY="-1.0" ArrowHead="TBar"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="dd094">
   <Interaction GraphId="dd094">
     <Graphics ZOrder="33713" LineThickness="1.0">
     <Graphics ZOrder="33713" LineThickness="1.0">
-
       <Point X="193.16666666666663" Y="349.35714285714266" GraphRef="ee2b4" RelX="0.0" RelY="1.0" />
+
       <Point X="193.16666666666663" Y="349.35714285714266" GraphRef="ee2b4" RelX="0.0" RelY="1.0"/>
-
       <Point X="149.0714285714286" Y="415.88095238095235" GraphRef="ad8c2" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="149.0714285714286" Y="415.88095238095235" GraphRef="ad8c2" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="a1763">
   <Interaction GraphId="a1763">
     <Graphics ZOrder="33714" LineStyle="Broken" LineThickness="1.0">
     <Graphics ZOrder="33714" LineStyle="Broken" LineThickness="1.0">
-
       <Point X="970.1190476190476" Y="134.59523809523813" GraphRef="c882f" RelX="0.0" RelY="1.0" />
+
       <Point X="970.1190476190476" Y="134.59523809523813" GraphRef="c882f" RelX="0.0" RelY="1.0"/>
-
       <Point X="671.0" Y="358.287557440792" GraphRef="b86f8" RelX="0.5" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="671.0" Y="358.287557440792" GraphRef="b86f8" RelX="0.5" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="bad33">
   <Interaction GraphId="bad33">
     <Graphics ConnectorType="Elbow" ZOrder="33716" LineThickness="1.0">
     <Graphics ConnectorType="Elbow" ZOrder="33716" LineThickness="1.0">
-
       <Point X="221.37895538787905" Y="926.1775850005804" GraphRef="b2dcb" RelX="0.0" RelY="1.0" />
+
       <Point X="221.37895538787905" Y="926.1775850005804" GraphRef="b2dcb" RelX="0.0" RelY="1.0"/>
-
       <Point X="254.54562205454545" Y="1000.8442516672484" GraphRef="d1a46" RelX="-1.0" RelY="0.0" ArrowHead="mim-transcription-translation" />
+
       <Point X="254.54562205454545" Y="1000.8442516672484" GraphRef="d1a46" RelX="-1.0" RelY="0.0" ArrowHead="mim-transcription-translation"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Interaction GraphId="e9104">
   <Interaction GraphId="e9104">
     <Graphics ZOrder="33730" LineStyle="Broken" LineThickness="1.0">
     <Graphics ZOrder="33730" LineStyle="Broken" LineThickness="1.0">
-
       <Point X="357.37895538787905" Y="1050.344251667249" GraphRef="d1a46" RelX="0.0" RelY="1.0" />
+
       <Point X="357.37895538787905" Y="1050.344251667249" GraphRef="d1a46" RelX="0.0" RelY="1.0"/>
-
       <Point X="357.0" Y="1110.5" GraphRef="cbaef" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+
       <Point X="357.0" Y="1110.5" GraphRef="cbaef" RelX="0.0" RelY="-1.0" ArrowHead="Arrow"/>
     </Graphics>
     </Graphics>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </Interaction>
   </Interaction>
   <Label TextLabel="ITGA" GraphId="af675">
   <Label TextLabel="ITGA" GraphId="af675">
-
     <Graphics CenterX="193.16666666666663" CenterY="123.14285714285728" Width="57.38095238095241" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="Rectangle" />
+
     <Graphics CenterX="193.16666666666663" CenterY="123.14285714285728" Width="57.38095238095241" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="Rectangle"/>
   </Label>
   </Label>
   <Label TextLabel="RTK" GraphId="ccf29">
   <Label TextLabel="RTK" GraphId="ccf29">
-
     <Graphics CenterX="606.5" CenterY="125.0" Width="73.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="Rectangle" />
+
     <Graphics CenterX="606.5" CenterY="125.0" Width="73.0" Height="25.0" ZOrder="28672" FillColor="ffffff" FontSize="12" Valign="Middle" ShapeType="Rectangle"/>
   </Label>
   </Label>
   <Label TextLabel="Proliferation, differentiation" GraphId="eb9ba">
   <Label TextLabel="Proliferation, differentiation" GraphId="eb9ba">
-
     <Graphics CenterX="651.4999999999999" CenterY="1156.8053221288517" Width="178.99999999999977" Height="26.38935574229663" ZOrder="33314" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="651.4999999999999" CenterY="1156.8053221288517" Width="178.99999999999977" Height="26.38935574229663" ZOrder="33314" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Label TextLabel="Cell Survival" GraphId="fa101">
   <Label TextLabel="Cell Survival" GraphId="fa101">
-
     <Graphics CenterX="873.2318865997869" CenterY="1060.6612935500368" Width="113.66666666666833" Height="28.677412899926367" ZOrder="33690" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="873.2318865997869" CenterY="1060.6612935500368" Width="113.66666666666833" Height="28.677412899926367" ZOrder="33690" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
-
   <Label TextLabel="uncontrolled proliferation&#xA;Increased survival&#xA;Genomic instability" GraphId="cbaef">
+
   <Label TextLabel="uncontrolled proliferation&#10;Increased survival&#10;Genomic instability" GraphId="cbaef">
-
     <Graphics CenterX="357.0" CenterY="1140.25" Width="146.0" Height="59.5" ZOrder="33729" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+
     <Graphics CenterX="357.0" CenterY="1140.25" Width="146.0" Height="59.5" ZOrder="33729" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
   </Label>
   </Label>
   <Shape TextLabel="Scaffold" GraphId="fae50">
   <Shape TextLabel="Scaffold" GraphId="fae50">
-
     <Graphics CenterX="661.6801347027096" CenterY="730.3094869703334" Width="122.6397305945809" Height="189.38102605933318" ZOrder="-6" FillColor="ededed" FontSize="10" Align="Left" ShapeType="RoundedRectangle" Color="999999" Rotation="0.0" />
+
     <Graphics CenterX="661.6801347027096" CenterY="730.3094869703334" Width="122.6397305945809" Height="189.38102605933318" ZOrder="-6" FillColor="ededed" FontSize="10" Align="Left" ShapeType="RoundedRectangle" Color="999999" Rotation="0.0"/>
   </Shape>
   </Shape>
   <Shape TextLabel="Nucleus" GraphId="f39e2">
   <Shape TextLabel="Nucleus" GraphId="f39e2">
-
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus" />
+
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus"/>
-
     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
+
     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/>
-
     <Graphics CenterX="613.0" CenterY="1037.0" Width="950.0" Height="334.0" ZOrder="16384" FontSize="12" Valign="Bottom" Align="Right" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
+
     <Graphics CenterX="613.0" CenterY="1037.0" Width="950.0" Height="334.0" ZOrder="16384" FontSize="12" Valign="Bottom" Align="Right" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/>
   </Shape>
   </Shape>
   <Shape TextLabel="Melanocyte" GraphId="f5d4c">
   <Shape TextLabel="Melanocyte" GraphId="f5d4c">
-
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" />
+
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell"/>
-
     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
+
     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/>
-
     <Graphics CenterX="630.0" CenterY="679.0" Width="1180.0" Height="1110.0" ZOrder="16384" FontSize="12" Align="Right" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
+
     <Graphics CenterX="630.0" CenterY="679.0" Width="1180.0" Height="1110.0" ZOrder="16384" FontSize="12" Align="Right" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0"/>
   </Shape>
   </Shape>
-
   <Group GroupId="d04cd" GraphId="aa385" Style="Group" />
+
   <Group GroupId="d04cd" GraphId="aa385" Style="Group"/>
-
   <Group GroupId="d1e03" GraphId="b86f8" Style="Group" />
+
   <Group GroupId="d1e03" GraphId="b86f8" Style="Group"/>
-
   <Group GroupId="d89cb" GraphId="b9d21" Style="Group" />
+
   <Group GroupId="d89cb" GraphId="b9d21" Style="Group"/>
-
   <Group GroupId="ae7fb" GraphId="bdc0d" Style="Group" />
+
   <Group GroupId="ae7fb" GraphId="bdc0d" Style="Group"/>
-
   <Group GroupId="c1818" GraphId="c5812" Style="Group" />
+
   <Group GroupId="c1818" GraphId="c5812" Style="Group"/>
-
   <Group GroupId="c2665" GraphId="cec9d" Style="Complex" />
+
   <Group GroupId="c2665" GraphId="cec9d" Style="Complex"/>
-
   <Group GroupId="d4179" GraphId="d1a46" Style="Pathway" />
+
   <Group GroupId="d4179" GraphId="d1a46" Style="Pathway"/>
-
   <Group GroupId="ba758" GraphId="d6e9c" Style="Group" />
+
   <Group GroupId="ba758" GraphId="d6e9c" Style="Group"/>
-
   <Group GroupId="feed9" GraphId="e1fd3" Style="Complex" />
+
   <Group GroupId="feed9" GraphId="e1fd3" Style="Complex"/>
-
   <Group GroupId="dddcb" GraphId="e24c8" Style="Group" />
+
   <Group GroupId="dddcb" GraphId="e24c8" Style="Group"/>
-
   <Group GroupId="a1796" GraphId="e48a0" Style="Group" />
+
   <Group GroupId="a1796" GraphId="e48a0" Style="Group"/>
-
   <Group GroupId="faf35" GraphId="f6d68" Style="Group" />
+
   <Group GroupId="faf35" GraphId="f6d68" Style="Group"/>
-
   <InfoBox CenterX="0.0" CenterY="0.0" />
+
   <InfoBox CenterX="0.0" CenterY="0.0"/>
   <Biopax>
   <Biopax>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb5">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="cb5">
Line 846: Line 848:
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca0">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ca0">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://www.kegg.jp/dbget-bin/www_bget?pathway+hsa05218</bp:SOURCE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://www.kegg.jp/dbget-bin/www_bget?pathway+hsa05218</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d64">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d64">

Revision as of 20:56, 16 August 2019

ScaffoldKRASPNRASP5, 6MelanocyteNucleusRTKITGAPREX2PAK1RAC1SorafenibVCLERBB4KITVemurafenibNF1ETS1GRM3p38 MAPK SignalingSTK19KDR24341, 4, 89+4, 7+8GRB2SOS2SOS1HRASPARAFBRAFRAF1PPMAP2K1PPMAPK1PPMAPK3PPMP1MAP2K2PPSHC2Proliferation, differentiationELK1PPPFOSCREB1PIK3CAPIK3R1PIK3R2PIK3CBPIK3CDPIK3R3PIP3AKT1AKT3AKT2BADPCell SurvivalPTENRegorafenibDabrafenibCobimetinibBinimetinibGRIN2ACALM1CALM2CALM3CALML3CALML4CALML5CALML6Regulation of Actin CytoskeletonTP53CDKN1ABAXDDB2POLKBAK1GADD45GGADD45AGADD45Buncontrolled proliferationIncreased survivalGenomic instability


Description

draft

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Prickett TD, Agrawal NS, Wei X, Yates KE, Lin JC, Wunderlich JR, Cronin JC, Cruz P, Rosenberg SA, Samuels Y; ''Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.''; Nat Genet, 2009 PubMed Europe PMC
  2. Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA; ''Melanoma genome sequencing reveals frequent PREX2 mutations.''; Nature, 2012 PubMed Europe PMC
  3. Kunz M, Vera J; ''Modelling of Protein Kinase Signaling Pathways in Melanoma and Other Cancers.''; Cancers (Basel), 2019 PubMed Europe PMC
  4. ''Genomic Classification of Cutaneous Melanoma.''; Cell, 2015 PubMed Europe PMC
  5. ''''; https://www.kegg.jp/dbget-bin/www_bget?pathway+hsa05218,
  6. Postow MA, Carvajal RD; ''Therapeutic implications of KIT in melanoma.''; Cancer J, 2012 PubMed Europe PMC
  7. Prickett TD, Wei X, Cardenas-Navia I, Teer JK, Lin JC, Walia V, Gartner J, Jiang J, Cherukuri PF, Molinolo A, Davies MA, Gershenwald JE, Stemke-Hale K, Rosenberg SA, Margulies EH, Samuels Y; ''Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.''; Nat Genet, 2011 PubMed Europe PMC
  8. Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R; ''Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.''; Nat Genet, 2012 PubMed Europe PMC
  9. Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DS, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L; ''A landscape of driver mutations in melanoma.''; Cell, 2012 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106231view00:24, 17 August 2019KhanspersModified description
106230view00:08, 17 August 2019Khanspersadded final parts
106229view22:32, 16 August 2019Khanspersbetter defined CDKN2A content
106228view21:27, 16 August 2019Khanspersmore CDKN2A content
106227view21:23, 16 August 2019KhanspersAdding CDKN2A content
106226view21:06, 16 August 2019Khanspersupdated phospho sites
106225view21:00, 16 August 2019Khanspersadded legend, fixed interaction
106224view20:56, 16 August 2019KhanspersModified description
106189view12:08, 16 August 2019MaintBotHMDB identifier normalization
105702view05:07, 14 August 2019Khanspersadded KEGG reference
105701view00:05, 14 August 2019KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
AKT2GeneProductENSG00000105221 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11652
AKT3GeneProductENSG00000117020 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:23797
ARAFGeneProductENSG00000078061 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BRAFGeneProduct673 (Entrez Gene)
BinimetinibMetaboliteQ19903515 (Wikidata)
CALM1GeneProductENSG00000198668 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
CALML4GeneProductENSG00000129007 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
CALML6GeneProductENSG00000169885 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
CobimetinibMetaboliteQ15708292 (Wikidata)
DDB2GeneProductENSG00000134574 (Ensembl)
DabrafenibMetaboliteCHEBI:75045 (ChEBI)
ELK1GeneProduct2002 (Entrez Gene)
ERBB4GeneProductENSG00000178568 (Ensembl)
ETS1GeneProductENSG00000134954 (Ensembl)
FOSGeneProduct2353 (Entrez Gene)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GRB2GeneProduct2885 (Entrez Gene)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRM3GeneProductENSG00000198822 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl)
KITGeneProductENSG00000157404 (Ensembl)
KRASGeneProduct3845 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MP1GeneProduct8649 (Entrez Gene)
NF1GeneProductENSG00000196712 (Ensembl)
NRASGeneProduct4893 (Entrez Gene)
PAK1GeneProductENSG00000149269 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3CBGeneProductENSG00000051382 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CDGeneProductENSG00000171608 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3R1GeneProductENSG00000145675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2GeneProductENSG00000105647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
PIP3MetaboliteHMDB0004249 (HMDB)
POLKGeneProductENSG00000122008 (Ensembl)
PREX2GeneProductENSG00000046889 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19211
RAC1GeneProductENSG00000136238 (Ensembl)
RAF1GeneProduct5894 (Entrez Gene)
RegorafenibMetaboliteCHEBI:68647 (ChEBI)
Regulation of Actin CytoskeletonPathwayWP51 (WikiPathways)
SHC2GeneProductENSG00000129946 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProduct6655 (Entrez Gene)
STK19GeneProductENSG00000204344 (Ensembl)
SorafenibMetaboliteHMDB0014542 (HMDB)
TP53GeneProductENSG00000141510 (Ensembl)
VCLGeneProductENSG00000035403 (Ensembl)
VemurafenibMetaboliteCHEBI:63637 (ChEBI)
p38 MAPK SignalingPathwayWP400 (WikiPathways)

Annotated Interactions

No annotated interactions

Personal tools