Head and Neck Squamous Cell Carcinoma (Homo sapiens)

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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Head and Neck Squamous Cell Carcinoma" Version="20190725" Organism="Homo sapiens">
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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Head and Neck Squamous Cell Carcinoma" Version="20190725" Organism="Homo sapiens"><Comment Source="WikiPathways-description">HNSCC, which includes malignant squamous lesions arising in the oral cavity, larynx and pharynx, is the sixth most common cancer in the world, with approximately 500,000 new cases annually.
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HNSCC has a remarkable multiplicity and diversity of genetic alterations. Most genomic alterations in HNSCC converge in a handful of molecular pathways resulting in cell cycle deregulation, genomic instability, cell differentiation defects, and persistent mitogenic signaling, the latter involving aberrant PI3K/mTOR pathway activation thereby rendering HNSCC responsive to PI3K/mTOR inhibitors.
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Description is modified from [https://europepmc.org/articles/PMC4348071 Iglesias-Bartolome et al].</Comment>
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     <Graphics CenterX="1703.1270923825828" CenterY="59.932266313759655" Width="20.0" Height="20.0" ZOrder="33765" FontSize="12" Valign="Middle" ShapeType="Triangle" Rotation="0.0"/>
   </Shape>
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   <Shape TextLabel="^" GraphId="a9f77">
   <Shape TextLabel="^" GraphId="a9f77">
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     <Graphics CenterX="1704.0" CenterY="117.0" Width="20.0" Height="20.0" ZOrder="33766" FontSize="16" Valign="Middle" ShapeType="Rectangle" Rotation="0.0" />
+
     <Graphics CenterX="1704.0" CenterY="117.0" Width="20.0" Height="20.0" ZOrder="33766" FontSize="16" Valign="Middle" ShapeType="Rectangle" Rotation="0.0"/>
   </Shape>
   </Shape>
   <Shape GraphId="cbe82">
   <Shape GraphId="cbe82">
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     <Graphics CenterX="1703.1270923825828" CenterY="87.38340419863245" Width="20.0" Height="20.0" ZOrder="33767" FontSize="12" Valign="Middle" ShapeType="Hexagon" Rotation="0.0" />
+
     <Graphics CenterX="1703.1270923825828" CenterY="87.38340419863245" Width="20.0" Height="20.0" ZOrder="33767" FontSize="12" Valign="Middle" ShapeType="Hexagon" Rotation="0.0"/>
   </Shape>
   </Shape>
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+
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+
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+
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+
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+
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-
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+
   <Group GroupId="ecdd1" GraphId="dd394" Style="Group"/>
-
   <Group GroupId="b1ebf" GraphId="dd419" Style="Group" TextLabel="AKT" />
+
   <Group GroupId="b1ebf" GraphId="dd419" Style="Group" TextLabel="AKT"/>
-
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+
   <Group GroupId="e2a6a" GraphId="deb35" Style="Group"/>
-
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+
   <Group GroupId="b42f9" GraphId="e87e2" Style="Group"/>
-
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+
   <Group GroupId="d3c7d" GraphId="f48b2" Style="Group"/>
-
   <Group GroupId="f3b7c" GraphId="f595e" Style="Complex" />
+
   <Group GroupId="f3b7c" GraphId="f595e" Style="Complex"/>
-
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+
   <Group GroupId="b44cf" GraphId="f6641" Style="Group"/>
-
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+
   <Group GroupId="d4f15" GraphId="f77f0" Style="Complex"/>
-
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+
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-
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+
   <Group GroupId="e14c5" GraphId="f9f69" Style="Group"/>
-
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+
   <Group GroupId="c15a6" Style="Group"/>
-
   <InfoBox CenterX="0.0" CenterY="0.0" />
+
   <InfoBox CenterX="0.0" CenterY="0.0"/>
   <Biopax>
   <Biopax>
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
Line 911: Line 914:
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="da3">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="da3">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Website:</bp:TITLE>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Website:</bp:TITLE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://clinicalgate.com/the-molecular-pathogenesis-of-head-and-neck-cancer/</bp:SOURCE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://clinicalgate.com/the-molecular-pathogenesis-of-head-and-neck-cancer/</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
+
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Website:</bp:TITLE>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Website:</bp:TITLE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://clinicalgate.com/the-molecular-pathogenesis-of-head-and-neck-cancer/</bp:SOURCE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">https://clinicalgate.com/the-molecular-pathogenesis-of-head-and-neck-cancer/</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
     </bp:PublicationXref>
     </bp:PublicationXref>
   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
107474view23:12, 10 October 2019KhanspersModified description
107473view23:09, 10 October 2019Khanspersupdated content
107182view14:27, 17 September 2019MaintBotChEBI identifier normalization
106612view13:07, 11 September 2019Marvin M2Ontology Term : 'head and neck carcinoma' added !
106315view19:35, 20 August 2019Khanspersupdated interactions
106314view19:06, 20 August 2019Khanspersupdated CDKN2A
105371view15:17, 5 August 2019DeSlUpdated second title field for website link (since it wasn't visualised on page)
105370view15:15, 5 August 2019DeSlAdded title for website link.
105369view15:12, 5 August 2019DeSlConnected unconnected lines
105358view07:42, 4 August 2019EgonwTwo gene-gene interactions that are not mim-conversion.
105339view21:30, 1 August 2019KhanspersAdded Ras/Raf arm
105338view21:24, 1 August 2019KhanspersAdded GAB1, updated layout, changed title
105337view21:01, 1 August 2019Khanspersremoved erroneous lit refs
105336view20:50, 1 August 2019KhanspersNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/1/1f/WP4674_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/1/1f/WP4674_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 107474)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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