Small cell lung cancer (Homo sapiens)

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ProliferationResistance to apoptosis signalsAngiogenesisReduced apoptosisCell-cycle progressionG1/S progressionTumor progressionNeuroendocrine epithelial cellsCKS1BRetinoic acidFHITMYCRXRACell cycleRARBRXRBRXRGDNA damageUncontrolled proliferationIncreased survivalGenomic instabilityTP53p53 SignalingPathwayCDKN1ABAXDDB2POLKBAK1GADD45GGADD45AGADD45BBCL2BAX+CYCSAPAF1CASP3CASP9CYCSCCNE1CCNE2CDK2PCDK6RB1PCDK4CCND1PE2F1E2F2E2F3SKP1CDKN1CCDKN1BCKS2MAXCDKN2BZBTB17LAMA1COL4A4LAMA2LAMA5LAMB1LAMC3LAMB2LAMA3COL4A2LAMA4LAMB3COL4A5COL4A6LAMC1FN1LAMC2COL4A1COL4A3LAMB4ITGB1ITGA6ITGA2ITGA2BITGA3ITGAVPIK3R1PIP3PTK2PIK3R3PTENAKT2PIK3R2PIK3CAAKT1PIK3CBAKT3PIK3CDIKBKGIKBKBCHUKNFKB1RELANFKB1RELANFKBIANFKBIBNFKBIANFKBIBUbiquitin-mediated proteolysisCCND1BIRC2BIRC3BIRC7BIRC8BCL2L1TRAF2TRAF3TRAF4TRAF5TRAF6TRAF1PTGS2NOS2Primary small cellcarcinomaMetastatic small cell carcinoma


Description

Pathways in small cell lung cancer

Quality Tags

Ontology Terms

 

Bibliography

  1. Deng WG, Nishizaki M, Fang B, Roth JA, Ji L; ''Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia
  2. ''KEGG small cell lung cancer''; https://www.kegg.jp/dbget-bin/www_bget?pathway+map05222,

History

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CompareRevisionActionTimeUserComment
108148view10:35, 29 November 2019FehrhartOntology Term : 'lung cancer' added !
108147view10:35, 29 November 2019FehrhartOntology Term : 'cancer' added !
108146view10:35, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106808view13:28, 17 September 2019MaintBotHMDB identifier normalization
105318view00:01, 30 July 2019Khanspersupdated labels
105188view22:30, 17 July 2019Khanspersminor update to DNA Damage Response
105187view22:09, 17 July 2019Khanspersupdated NFKB activation, interrupted effects
105186view22:02, 17 July 2019Khanspersfixed legend and added FHIT info
105185view21:55, 17 July 2019Khanspersupdated interrupted interactions, legend
105184view21:33, 17 July 2019KhanspersModified description
105183view21:27, 17 July 2019Khanspersadded phosphosites etc
105153view21:29, 12 July 2019Khanspersexpanded FHIT information
105033view03:24, 2 July 2019Khansperswork in progress
105032view03:01, 2 July 2019KhanspersModified description
105031view03:00, 2 July 2019KhanspersModified description
104975view16:15, 27 June 2019KhanspersOntology Term : 'signaling pathway' added !
104974view16:15, 27 June 2019KhanspersOntology Term : 'small cell lung carcinoma pathway' added !
104973view16:14, 27 June 2019KhanspersModified title
104972view16:13, 27 June 2019KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
APAF1GeneProductENSG00000120868 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIRC2GeneProductENSG00000110330 (Ensembl)
BIRC3GeneProductENSG00000023445 (Ensembl)
BIRC7GeneProductENSG00000101197 (Ensembl)
BIRC8GeneProductENSG00000163098 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCNE1GeneProductENSG00000105173 (Ensembl) CCNE1; cyclin E
CCNE2GeneProductENSG00000175305 (Ensembl) CCNE2; cyclin E
CDK2GeneProductENSG00000123374 (Ensembl) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProductENSG00000135446 (Ensembl) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProductENSG00000105810 (Ensembl) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN1CGeneProductENSG00000129757 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2BGeneProductENSG00000147883 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CKS1BGeneProductENSG00000173207 (Ensembl)
CKS2GeneProductENSG00000123975 (Ensembl)
COL4A1GeneProduct1282 (Entrez Gene)
COL4A2GeneProduct1284 (Entrez Gene)
COL4A3GeneProductENSG00000169031 (Ensembl)
COL4A4GeneProduct1286 (Entrez Gene)
COL4A5GeneProductENSG00000188153 (Ensembl)
COL4A6GeneProduct1288 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl)
Cell cyclePathway
DDB2GeneProductENSG00000134574 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl) E2F1; E2F transcription factor 1
E2F2GeneProductENSG00000007968 (Ensembl) E2F2; E2F transcription factor 2
E2F3GeneProductENSG00000112242 (Ensembl) E2F3; E2F transcription factor 3
FHITGeneProductENSG00000189283 (Ensembl)
FN1GeneProduct2335 (Entrez Gene)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
ITGA2GeneProduct3673 (Entrez Gene)
ITGA2BGeneProduct3674 (Entrez Gene)
ITGA3GeneProduct3675 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene)
ITGAVGeneProduct3685 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
LAMA1GeneProduct284217 (Entrez Gene)
LAMA2GeneProduct3908 (Entrez Gene)
LAMA3GeneProduct3909 (Entrez Gene)
LAMA4GeneProduct3910 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
LAMB3GeneProduct3914 (Entrez Gene)
LAMB4GeneProductENSG00000091128 (Ensembl)
LAMC1GeneProduct3915 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
LAMC3GeneProduct10319 (Entrez Gene)
MAXGeneProductENSG00000125952 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIBGeneProductENSG00000104825 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP3MetaboliteHMDB04249 (HMDB)
POLKGeneProductENSG00000122008 (Ensembl)
PTENGeneProduct5728 (Entrez Gene)
PTGS2GeneProductENSG00000073756 (Ensembl)
PTK2GeneProduct5747 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
RARBGeneProductENSG00000077092 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
Retinoic acidMetaboliteCHEBI:6067 (ChEBI)
SKP1GeneProductENSG00000113558 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TRAF1GeneProductENSG00000056558 (Ensembl)
TRAF2GeneProductENSG00000127191 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF4GeneProductENSG00000076604 (Ensembl)
TRAF5GeneProductENSG00000082512 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
Ubiquitin-mediated proteolysisPathwayWP183 (WikiPathways)
ZBTB17GeneProductENSG00000116809 (Ensembl)
p53 Signaling PathwayPathway

Annotated Interactions

No annotated interactions

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