Measles virus infection (Homo sapiens)

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NucleusEndosomeT cellNucleusMitochondriaPeripheral blood lymphocyteDendritic cellMeasles virusMV genome RNALegendLymphocyteMeasles virus structural proteinMeasles virus entryand replicationDendritic cellapoptosisInhibition of the establishmentof an antiviral stateMeasles virusinfectionVirus buddingCell cycle retardationInhibition of cell deathMV RNAVirus genome replicationEscape from innateimmune systemIFNA5TRADDCDKN1BCSNK2A3FIL2CCND1IFNA8CSNK2BEIF2AK1RIG-1-like receptorsignaling pathwayMAVSJAK1IFNB1OAS1IFNA6CD28IRF3EIF2AK1EIF2AK2EIF2AK3EIF2S1CD46RACK1IRF9IRF7CASP8TLR7IFNA16FADDDDX58GSK3BHSPA8IL2RACSNK2A2CDK2TNFAIP3IL1A?STAT3Ubiquitin-mediatedproteolysisCYCSIFNA7HSPA1ABIDEIF2AK2IL6PIP3EIF2AK4CD3DAKT1IFNA2HSPA1LNECTIN4Cell CycleEIF2AK4HSPA6ADAREIF3HTP53IFNA4IFNA1FASLG?IFNA14RCHY1BBC3LPSFASPIFNA13CBLBRAB9APIK3CATLR2VIFNA10CSNK2A1p53 siganling pathway1SLAMF1MSNCLEC4MCD209TLR4TRAF6TAB2IRAK1MAP3K7IRAK4MYD88CHUKIKBKGIKBKBMAPK10MAPK8MAPK9JUNFOSNFKB1NFKBIARELANFKB2IL1BIL12AIL12BIFIH12TRAF3TBK1IKBKEVPCVCNIFNA17IFNA21TLR9MYD88IRAK1IRAK4CHUKIKBKGIKBKBNFKB1NFKBIARELANFKB2IFNAR1IFNAR2TYK2JAK1STAT1STAT2VPCOAS2OAS3MX1EIF2AK3BADBAXBAK1BCL2BCL2L1APAF1CASP9CASP3ImmunosupressionHMNPLRAB9BTP73PVCHSPA1BHSPA2HSPA2NPInhibited host translationFHHCDK4CDK6CCND2CCND3CCNE1CCNE2?IL2RBIL2RGCD3ECD3GJAK3STAT5ASTAT5BAKT2AKT3PIK3CBPIK3CDPIK3R1PIK3R2PIK3R3FNPLHMMeasles virus non- structural proteinCV2


Description

The measles virus is a single-stranded, negative-sense virus that exclusively infects humans. The measles virus has two surface proteins responsible for binding and fusion to target cells: hemagglutinin (H) and membrane fusion protein (F). Multiple receptors have been identified to bind these surface proteins: CD46, SLAM, Nectin-4 and TLR. The viral proteins P, V and C suppress the innate immune response by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. The virus also causes inhibition of IL-12 expression in dendritic cells, via H proteins on viral particles as well as N proteins from infected cells.

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Ontology Terms

 

Bibliography

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  1. Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C; ''Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.''; J Virol, 2000 PubMed Europe PMC
  2. ''''; https://www.genome.jp/dbget-bin/www_bget?pathway+hsa05162,
  3. Mesman AW, Zijlstra-Willems EM, Kaptein TM, de Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI, Geijtenbeek TB; ''Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.''; Cell Host Microbe, 2014 PubMed Europe PMC
  4. Susanne Rauch, Oliver T. Fackler; ''Viruses, lipid rafts and signal transduction''; https://doi.org/10.1002/sita.200600113, 2007
  5. Avota E, Müller N, Klett M, Schneider-Schaulies S; ''Measles virus interacts with and alters signal transduction in T-cell lipid rafts.''; J Virol, 2004 PubMed Europe PMC
  6. Noyce RS, Richardson CD; ''Nectin 4 is the epithelial cell receptor for measles virus.''; Trends Microbiol, 2012 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
107450view17:17, 9 October 2019Khanspersupdated content
107449view00:42, 9 October 2019Khanspersupdate DC info
107448view00:19, 9 October 2019KhanspersAdded lit refs for T-cell content, updated content
107445view19:47, 8 October 2019Khanspersupdated details for T cell
107444view18:42, 8 October 2019Khanspersadded KEGG reference
107443view18:41, 8 October 2019KhanspersModified description
107442view18:40, 8 October 2019Khanspersfixed interactions
105224view19:32, 22 July 2019KhanspersAdded interaction between dendritic cell and infected cell
105211view17:12, 20 July 2019Khanspersadded peripheral blood lymphocyte
105210view16:46, 20 July 2019Khansperswork in progress
105206view00:29, 20 July 2019Khanspersupdated NFKb activation
105205view00:12, 20 July 2019Khanspersupdated legend
104951view18:59, 26 June 2019KhanspersOntology Term : 'signaling pathway pertinent to immunity' added !
104950view18:57, 26 June 2019KhanspersOntology Term : 'viral infectious disease' added !
104949view18:57, 26 June 2019KhanspersOntology Term : 'measles' added !
104946view17:29, 26 June 2019KhanspersModified description
104681view22:57, 10 June 2019Khanspersreorganization
104680view22:15, 10 June 2019Khanspersreorganization in progress
104679view21:39, 10 June 2019KhanspersModified title
104678view21:39, 10 June 2019Khanspersadded nectin-4
104667view08:37, 8 June 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
104647view19:04, 7 June 2019Khanspersupdated pathway
104646view19:03, 7 June 2019KhanspersModified title
104638view06:57, 7 June 2019EgonwReplaced a secondary ChEBI ID with primary ID.
104628view23:20, 6 June 2019KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?GeneProduct
ADARGeneProductENSG00000160710 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
CGeneProduct
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CBLBGeneProductENSG00000114423 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProductENSG00000118971 (Ensembl)
CCND3GeneProductENSG00000112576 (Ensembl)
CCNE1GeneProductENSG00000105173 (Ensembl)
CCNE2GeneProductENSG00000175305 (Ensembl)
CD209GeneProductENSG00000090659 (Ensembl)
CD28GeneProductENSG00000178562 (Ensembl)
CD3DGeneProductENSG00000167286 (Ensembl)
CD3EGeneProductENSG00000198851 (Ensembl)
CD3GGeneProductENSG00000160654 (Ensembl)
CD46GeneProductENSG00000117335 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK6GeneProductENSG00000105810 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CHUKGeneProduct1147 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CLEC4MGeneProductENSG00000104938 (Ensembl)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Cell CyclePathway
DDX58GeneProductENSG00000107201 (Ensembl)
EIF2AK1GeneProductENSG00000086232 (Ensembl)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
EIF2AK4GeneProductENSG00000128829 (Ensembl)
EIF2S1GeneProductENSG00000134001 (Ensembl)
EIF3HGeneProductENSG00000147677 (Ensembl)
FGeneProduct
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FOSGeneProduct2353 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
GSK3BGeneProductENSG00000082701 (Ensembl)
HGeneProduct
HSPA1AGeneProductENSG00000204389 (Ensembl)
HSPA1BGeneProductENSG00000204388 (Ensembl)
HSPA1LGeneProductENSG00000204390 (Ensembl)
HSPA2GeneProductENSG00000126803 (Ensembl)
HSPA6GeneProductENSG00000173110 (Ensembl)
HSPA8GeneProductENSG00000109971 (Ensembl)
IFIH1GeneProductENSG00000115267 (Ensembl)
IFNA10GeneProductENSG00000186803 (Ensembl)
IFNA13GeneProductENSG00000233816 (Ensembl)
IFNA14GeneProductENSG00000228083 (Ensembl)
IFNA16GeneProductENSG00000147885 (Ensembl)
IFNA17GeneProductENSG00000234829 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNA21GeneProductENSG00000137080 (Ensembl)
IFNA2GeneProductENSG00000188379 (Ensembl)
IFNA4GeneProductENSG00000236637 (Ensembl)
IFNA5GeneProductENSG00000147873 (Ensembl)
IFNA6GeneProductENSG00000120235 (Ensembl)
IFNA7GeneProductENSG00000214042 (Ensembl)
IFNA8GeneProductENSG00000120242 (Ensembl)
IFNAR1GeneProductENSG00000142166 (Ensembl)
IFNAR2GeneProductENSG00000159110 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IKBKBGeneProduct3551 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct9641 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProduct8517 (Entrez Gene) Original kegg element: gene;85;hsa:8517
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL2RAGeneProductENSG00000134460 (Ensembl)
IL2RBGeneProductENSG00000100385 (Ensembl)
IL2RGGeneProductENSG00000147168 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IRAK1GeneProduct3654 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK4GeneProduct51135 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JAK3GeneProductENSG00000105639 (Ensembl)
JUNGeneProduct3725 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LGeneProduct
LPSMetaboliteCHEBI:16412 (ChEBI)
MGeneProduct
MAP3K7GeneProduct6885 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAPK10GeneProduct5602 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK8GeneProduct5599 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct5601 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAVSGeneProductENSG00000088888 (Ensembl)
MSNGeneProductENSG00000147065 (Ensembl)
MX1GeneProductENSG00000157601 (Ensembl)
MYD88GeneProduct4615 (Entrez Gene) Original kegg element: gene;8;hsa:4615
NGeneProduct
NECTIN4GeneProductENSG00000143217 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKB2GeneProduct4791 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct4792 (Entrez Gene) Original kegg element: gene;64;hsa:4792
OAS1GeneProductENSG00000089127 (Ensembl)
OAS2GeneProductENSG00000111335 (Ensembl)
OAS3GeneProductENSG00000111331 (Ensembl)
PGeneProduct
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP3MetaboliteCHEBI:16618 (ChEBI)
RAB9AGeneProductENSG00000123595 (Ensembl)
RAB9BGeneProductENSG00000123570 (Ensembl)
RACK1GeneProductENSG00000204628 (Ensembl)
RCHY1GeneProductENSG00000163743 (Ensembl)
RELAGeneProduct5970 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIG-1-like receptor signaling pathwayPathway
SLAMF1GeneProductENSG00000117090 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
TAB2GeneProduct23118 (Entrez Gene) Original kegg element: gene;61;hsa:23118
TBK1GeneProduct29110 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR9GeneProductENSG00000239732 (Ensembl)
TNFAIP3GeneProductENSG00000118503 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TP73GeneProductENSG00000078900 (Ensembl)
TRADDGeneProductENSG00000102871 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProduct7189 (Entrez Gene) Original kegg element: gene;53;hsa:7189
TYK2GeneProductENSG00000105397 (Ensembl)
Ubiquitin-mediated proteolysisPathway
VGeneProduct
p53 siganling pathwayPathway

Annotated Interactions

No annotated interactions

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