Cholesterol Biosynthesis (Rattus norvegicus)

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1-7Fatty Acid Degradation7-DehydrocholesterolGeranyl-PPHmgcs1MVKDimethylallylpyrophosphateisopentenyl pyrophosphateSqualenefarnesyl pyrophosphateHMG-CoASc5dlLanosterinPmvkIdi1Hmgcr(S)-2,3-EpoxysqualeneAcetyl-CoAMevalonic acidFdpsLssSqleMevalonic acid-5PFdft1NsdhlLathosterolMvdFdpsCyp51Mevalonic acid 5-pyrophosphateCholesterolDhcr7Sc4mol


Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP197(r21093) with a 88% conversion rate.

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Ontology Terms



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  1. Noshiro M, Aoyama Y, Kawamoto T, Gotoh O, Horiuchi T, Yoshida Y; ''Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.''; J Biochem, 1997 PubMed Europe PMC
  2. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; ''Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC
  3. Liu XY, Dangel AW, Kelley RI, Zhao W, Denny P, Botcherby M, Cattanach B, Peters J, Hunsicker PR, Mallon AM, Strivens MA, Bate R, Miller W, Rhodes M, Brown SD, Herman GE; ''The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.''; Nat Genet, 1999 PubMed Europe PMC
  4. Gaylor JL; ''Membrane-bound enzymes of cholesterol synthesis from lanosterol.''; Biochem Biophys Res Commun, 2002 PubMed Europe PMC
  5. Li L, Kaplan J; ''Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.''; J Biol Chem, 1996 PubMed Europe PMC
  6. Ohashi M, Mizushima N, Kabeya Y, Yoshimori T; ''Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.''; J Biol Chem, 2003 PubMed Europe PMC
  7. Sagami H, Korenaga T, Ogura K; ''Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.''; J Biochem, 1993 PubMed Europe PMC


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101817view09:49, 10 November 2018EgonwReplaced a wrong CAS number of with right ChEBI identifier.
71765view20:29, 17 October 2013MaintBotAutomated update of data sources
69324view18:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
67114view10:08, 26 June 2013Christine ChichesterOntology Term : 'cholesterol biosynthetic pathway' added !
41635view02:33, 2 March 2011MaintBotRemoved redundant pathway information and comments
35146view14:15, 11 February 2010ThomasModified description
35144view14:15, 11 February 2010Thomasadded literature reference
35143view14:13, 11 February 2010Thomasmoved literature from genmapp comments to bibliography
34039view18:58, 9 December 2009MaintBotAutomatic update of empty xrefs
32111view13:48, 14 August 2009MaintBotFixed group labels
31011view01:05, 30 July 2009MaintBotConverted from Homo sapiens
21650view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Cholesterol Biosynthesis]] moved to [[Pathway:WP461]]: Moved to stable identifier
7958view13:46, 7 January 2008MaintBot[[Pathway:Rat:Cholesterol Biosynthesis]] moved to [[Pathway:Rattus norvegicus:Cholesterol Biosynthesis]]: Renaming species
7603view16:03, 18 December 2007MaintBotfixed category names
7336view12:42, 4 November 2007MaintBotAdded categories to GPML
19407view22:19, 22 May 2007N.Manteigpml file for [[Rat:Cholesterol_Biosynthesis]]
6525view22:19, 22 May 2007M.Liebermangpml file for [[Rat:Cholesterol_Biosynthesis]]

External references


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NameTypeDatabase referenceComment
(S)-2,3-EpoxysqualeneMetabolite9029-62-3 (CAS)
7-DehydrocholesterolMetabolite434-16-2 (CAS)
CholesterolMetabolite57-88-5 (CAS)
Cyp51GeneProduct25427 (Entrez Gene)
Dhcr7GeneProduct64191 (Entrez Gene)
DimethylallylpyrophosphateMetabolite358-72-5 (CAS)
Fdft1GeneProduct29580 (Entrez Gene)
FdpsGeneProduct83791 (Entrez Gene)
Geranyl-PPMetabolite6699-20-3 (CAS)
HmgcrGeneProduct25675 (Entrez Gene)
Hmgcs1GeneProduct29637 (Entrez Gene)
Idi1GeneProduct89784 (Entrez Gene)
LanosterinMetabolite79-63-0 (CAS)
LathosterolMetabolite80-99-9 (CAS)
LssGeneProduct81681 (Entrez Gene)
MVKGeneProduct81727 (Entrez Gene)
Mevalonic acid 5-pyrophosphateMetabolite1492-08-6 (CAS)
Mevalonic acid-5PMetabolite73566-35-5 (CAS)
Mevalonic acidMetabolite150-97-0 (CAS)
MvdGeneProduct81726 (Entrez Gene)
NsdhlGeneProduct309262 (Entrez Gene) NAD(P) dependent steroid dehydrogenase-like
PmvkGeneProduct310645 (Entrez Gene)
Sc4molGeneProduct140910 (Entrez Gene)
Sc5dlGeneProduct114100 (Entrez Gene)
SqleGeneProduct29230 (Entrez Gene)
SqualeneMetabolite111-02-4 (CAS)
farnesyl pyrophosphateMetabolite13058-04-3 (CAS)
isopentenyl pyrophosphateMetabolite358-71-4 (CAS)

Annotated Interactions

No annotated interactions
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