Metabolism of alpha-linolenic acid (Homo sapiens)

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1ElongaseArachidonic acidFADS2Linoleic acidFADS1Dihomo-gamma-linolenic acidgamma-Linolenic acidalpha-Linolenic acideicosapentaenoic aciddocosahexaenoic acidsElongaseFADS2FADS2FADS1LeukotrienesProstanoidsLXA4LXB4Prostaglandin G/H synthase 25-lipoxygenasePGH25-HPETE12-lipoxygenasePGG2Arachidonic acid5-HETE15-lipoxygenaseLTA4


Metabolism of alpha-linolenic acid and linoleic acid to their respective acids. Both of these processes are catalyzed primarily by FADS1 and FADS2.

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Ontology Terms



  1. Glen D. Lawrence; ''The Fats of Life: Essential Fatty Acids in Health and Disease''; 978-0-8135-4677-3, 2010


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106804view13:28, 17 September 2019MaintBotHMDB identifier normalization
105271view21:19, 25 July 2019Khanspersconverted legend interactions to graphical lines
105095view19:05, 5 July 2019AlexanderPicoModified title
104813view11:26, 19 June 2019ChrisAdded legend
104629view05:41, 7 June 2019EgonwReplaced a secondary ChEBI ID with primary ID.
104623view10:29, 5 June 2019ChrisAdded new datanodes and changed protein annotations
104619view08:38, 5 June 2019ChrisAdded new datanodes and changes protein annotations
104585view10:48, 3 June 2019ChrisModified description
104584view10:39, 3 June 2019ChrisModified title
104583view10:25, 3 June 2019Chris- Added another pathway - Added pathway ontology eicosanoids
104582view10:11, 3 June 2019ChrisOntology Term : 'eicosanoid metabolic pathway' added !
104520view13:29, 29 May 2019ChrisOntology Term : 'alpha-linoleic acid metabolic pathway' added !
104519view13:19, 29 May 2019ChrisModified description
104518view13:17, 29 May 2019ChrisModified title
104510view12:52, 29 May 2019Chris-Combined two pathways -Changed annotations
104373view10:23, 22 May 2019DeSlOntology Term : 'PW:0001158' removed !
104372view10:23, 22 May 2019DeSlOntology Term : 'linoleic acid metabolic pathway' added !
104371view10:23, 22 May 2019DeSlOntology Term : 'PW:0000001' removed !
104370view10:23, 22 May 2019DeSlOntology Term : 'alpha-linoleic acid metabolic pathway' added !
104272view05:52, 15 May 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
104120view10:31, 6 May 2019ChrisOntology Term : 'Pathway Ontology' added !
104119view10:30, 6 May 2019ChrisModified title
104118view10:27, 6 May 2019ChrisNew pathway

External references


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NameTypeDatabase referenceComment
12-lipoxygenaseProteinP18054 (Uniprot-SwissProt)
15-lipoxygenaseProteinP16050 (Uniprot-SwissProt)
5-HETEMetaboliteCHEBI:65341 (ChEBI)
5-HPETEMetaboliteHMDB11135 (HMDB)
5-lipoxygenaseProteinP09917 (Uniprot-SwissProt)
Arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
Dihomo-gamma-linolenic acidMetaboliteQ415398 (Wikidata)
FADS1ProteinO60427 (Uniprot-SwissProt)
FADS2ProteinO95864 (Uniprot-SwissProt)
LTA4MetaboliteCHEBI:15651 (ChEBI)
LXA4MetaboliteQ27082450 (Wikidata)
LXB4MetaboliteCHEBI:6499 (ChEBI)
Linoleic acidMetaboliteCHEBI:17351 (ChEBI)
PGG2MetaboliteCHEBI:27647 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
Prostaglandin G/H synthase 2ProteinP35354 (Uniprot-SwissProt)
alpha-Linolenic acidMetaboliteCHEBI:10298 (ChEBI)
docosahexaenoic acidsMetaboliteCHEBI:36005 (ChEBI)
eicosapentaenoic acidMetaboliteCHEBI:36006 (ChEBI)
gamma-Linolenic acidMetaboliteCHEBI:28661 (ChEBI)

Annotated Interactions

No annotated interactions

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