Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway (Homo sapiens)

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(Added ensembl IDs to geneproducts)
(Fixed interactions within the overview figure.)
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cao J</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Otto NM</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim DH</bp:AUTHORS>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Akt-dependent and -independent mechanisms of mTOR regulation in cancer.</bp:TITLE>
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      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2016</bp:YEAR>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jeon SM</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Memmott RM</bp:AUTHORS>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">mTOR regulation of autophagy.</bp:TITLE>
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      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">FEBS Lett</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jung CH</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ro SH</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cao J</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Otto NM</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kim DH</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tiranti V</bp:AUTHORS>
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      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a6e">
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18466115</bp:ID>
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       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem J</bp:SOURCE>
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      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Trends Cell Biol</bp:SOURCE>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
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      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2010</bp:YEAR>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang J</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Funderburk SF</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Manning BD</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang QJ</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yue Z</bp:AUTHORS>
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    </bp:PublicationXref>
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    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ffd">
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      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">30619462</bp:ID>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">&lt;i&gt;MECP2&lt;/i&gt;Mutation Interrupts Nucleolin-mTOR-P70S6K Signaling in Rett Syndrome Patients.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Front Genet</bp:SOURCE>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kroft D</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sheikholeslami K</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fuss D</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Buist M</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ali Sher A</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Del Bigio MR</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sztainberg Y</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Siu VM</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ang LC</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sabourin-Felix M</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moss T</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rastegar M</bp:AUTHORS>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Reduced neuronal size and mTOR pathway activity in the Mecp2 A140V Rett syndrome mouse model.</bp:TITLE>
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      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">F1000Res</bp:SOURCE>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gerald B</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hilbert A</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Narayanan V</bp:AUTHORS>
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    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f40">
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The mammalian ULK1 complex and autophagy initiation.</bp:TITLE>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structure of the human mTOR complex I and its implications for rapamycin inhibition.</bp:TITLE>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kang SA</bp:AUTHORS>
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    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d6c">
 
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Akt-dependent and -independent mechanisms of mTOR regulation in cancer.</bp:TITLE>
 
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dennis PA</bp:AUTHORS>
 
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       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.</bp:TITLE>
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       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cell Type</bp:Ontology>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nat Commun</bp:SOURCE>
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      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2017</bp:YEAR>
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    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bakula D</bp:AUTHORS>
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       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">neurodegeneration with brain iron accumulation</bp:TERM>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Muller AJ</bp:AUTHORS>
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       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0110734</bp:ID>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zuleger T</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Takacs Z</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Franz-Wachtel M</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Brigger D</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Frickey T</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Robenek H</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e9c">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e9c">
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Line 1,328: Line 1,311:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tooze SA</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tooze SA</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a1e">
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       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Structure of the human mTOR complex I and its implications for rapamycin inhibition.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations.</bp:TITLE>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mol Genet Metab</bp:SOURCE>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yip CK</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leoni V</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murata K</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zorzi G</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zibordi F</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kang SA</bp:AUTHORS>
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       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dusi S</bp:AUTHORS>
 +
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 +
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 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Caccia C</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Souza AL</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Deik A</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Clish CB</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rimoldi M</bp:AUTHORS>
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      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ciusani E</bp:AUTHORS>
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     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a6e">
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       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">&lt;i&gt;MECP2&lt;/i&gt;Mutation Interrupts Nucleolin-mTOR-P70S6K Signaling in Rett Syndrome Patients.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Front Genet</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochem J</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2018</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Olson CO</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Huang J</bp:AUTHORS>
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pejhan S</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Manning BD</bp:AUTHORS>
-
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+
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+
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+
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+
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+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sabourin-Felix M</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moss T</bp:AUTHORS>
+
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+
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   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Revision as of 17:09, 12 June 2019

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
107175view14:26, 17 September 2019MaintBotChEBI identifier normalization
105274view21:32, 25 July 2019KhanspersModified title
104795view06:57, 18 June 2019GMKeulenChanged background color of lipid metabolism.
104775view10:32, 13 June 2019GMKeulenAdded pathway node.
104774view10:16, 13 June 2019GMKeulenAdded CheBI identifiers, changed mim-interactions to arrows.
104766view17:09, 12 June 2019GMKeulenFixed interactions within the overview figure.
104762view15:59, 12 June 2019GMKeulenAdded ensembl IDs to geneproducts
104761view15:43, 12 June 2019GMKeulenChanged text lables to geneproducts within the overview figure.
104685view11:21, 11 June 2019GMKeulenAdded literature reference for mTOR ULK1 inhibition.
104618view11:03, 4 June 2019GMKeulenAdded annotation and literature reference to PANK2 reaction.
104387view12:56, 23 May 2019GMKeulenAdded colors
104385view12:46, 23 May 2019GMKeulenAdded literature reference to figure
104384view12:44, 23 May 2019GMKeulenChanged title
104383view12:42, 23 May 2019GMKeulenAdded legend to the figure and pathway
104382view11:15, 23 May 2019GMKeulenAdded overview of different NBIA subtypes
104378view16:57, 22 May 2019GMKeulenChanged arrows to diseases
104352view09:18, 20 May 2019GMKeulenChanged names in disease lables, Corrected FA2H reaction. Added lables to the green and blue boxes.
104283view12:34, 15 May 2019FehrhartOntology Term : 'neuron' added !
104281view12:29, 15 May 2019Fehrhartgraphical fix
104207view09:00, 10 May 2019GMKeulenModified description
104064view08:24, 1 May 2019GMKeulenadded L-cysteine and diphosphate to phosphopantothenate reaction
104057view14:22, 29 April 2019GMKeulenadded MECP2 and FA2H reaction
104054view10:50, 29 April 2019GMKeulenAdded enzymatic function of FA2H
104046view06:11, 27 April 2019EgonwReplaced a secondary ChEBI ID with its primary ID.
104045view12:59, 26 April 2019GMKeulenAdded metabolites, and disease FAHN
104044view12:09, 26 April 2019GMKeulenAdded rhea identifiers, annotated metabolites and added metabolites
104041view09:08, 26 April 2019GMKeulenOntology Term : 'disease pathway' added !
104040view09:08, 26 April 2019GMKeulenOntology Term : 'neurodegeneration with brain iron accumulation' added !
104008view14:22, 25 April 2019GMKeulenchanged layout
104005view12:46, 25 April 2019GMKeulenAnnotated metabolites with chebi identifier, linked diseases to OMIM and connected reactions.
104004view12:15, 25 April 2019GMKeulenconnected AMPK
103998view08:11, 25 April 2019GMKeulenModified description
103997view08:08, 25 April 2019DeSlConnected PANK2
103996view07:58, 25 April 2019DeSlConnected CoPAN
103995view07:54, 25 April 2019DeSlChanged characters for Muller and Urbe
103994view07:51, 25 April 2019DeSlchanged character to beta.
103993view07:41, 25 April 2019DeSlConnected AMPK to group, layout change
103989view12:50, 24 April 2019GMKeulenNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/7/73/WP4577_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/7/73/WP4577_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 104766)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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