GPCRs, Class B Secretin-like (Mus musculus)

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<?xml version="1.0" encoding="UTF-8"?> <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="GPCRs, Class B Secretin-like" Organism="Mus musculus"> <Comment Source="WikiPathways-category">Molecular Function</Comment> <Comment Source="HomologyConvert">This pathway was inferred from Homo sapiens pathway [http://www.wikipathways.org/index.php?title=Pathway:WP334&amp;amp;amp;amp;oldid=21381 WP334(r21381)] with a 91% conversion rate.</Comment> <Comment Source="WikiPathways-description">This pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.</Comment> <Graphics BoardWidth="602.5" BoardHeight="509.6666666666667"/> <DataNode TextLabel="Calcr" GraphId="ca0" Type="GeneProduct" GroupRef="f02df"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Calcr"/> <Graphics CenterX="96.0" CenterY="149.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12311"/> </DataNode> <DataNode TextLabel="Calcrl" GraphId="fc0" Type="GeneProduct" GroupRef="f02df"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Calcrl"/> <Graphics CenterX="96.0" CenterY="169.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="54598"/> </DataNode> <DataNode TextLabel="Crhr1" GraphId="db4" Type="GeneProduct" GroupRef="b4223"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Crhr1"/> <Graphics CenterX="96.0" CenterY="233.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12921"/> </DataNode> <DataNode TextLabel="Crhr2" GraphId="e1e" Type="GeneProduct" GroupRef="b4223"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Crhr2"/> <Graphics CenterX="96.0" CenterY="253.66666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="12922"/> </DataNode> <DataNode TextLabel="Gipr" GraphId="c52" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gipr"/> <Graphics CenterX="96.0" CenterY="311.6666666666667" Width="61.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="381853"/> </DataNode> <DataNode TextLabel="Glp2r" GraphId="f3f" Type="GeneProduct" GroupRef="a9b0a"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Glp2r"/> <Graphics CenterX="96.0" CenterY="371.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="93896"/> </DataNode> <DataNode TextLabel="Glp1r" GraphId="f31" Type="GeneProduct" GroupRef="a9b0a"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Glp1r"/> <Graphics CenterX="96.0" CenterY="391.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="14652"/> </DataNode> <DataNode TextLabel="Gcgr" GraphId="c13" Type="GeneProduct" GroupRef="a9b0a"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gcgr"/> <Graphics CenterX="96.0" CenterY="411.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="14527"/> </DataNode> <DataNode TextLabel="Ghrhr" GraphId="cab" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Ghrhr"/> <Graphics CenterX="96.0" CenterY="469.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="14602"/> </DataNode> <DataNode TextLabel="Pth2r" GraphId="a6d" Type="GeneProduct" GroupRef="a60b5"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pth2r"/> <Graphics CenterX="307.0" CenterY="143.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="213527"/> </DataNode> <DataNode TextLabel="Pth1r" GraphId="ac8" Type="GeneProduct" GroupRef="a60b5"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Pth1r"/> <Graphics CenterX="307.0" CenterY="163.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="19228"/> </DataNode> <DataNode TextLabel="Adcyap1r1" GraphId="f79" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Adcyap1r1"/> <Graphics CenterX="307.0" CenterY="216.0" Width="86.66666666666667" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="11517"/> </DataNode> <DataNode TextLabel="SCTR" GraphId="dd5" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Sctr"/> <Graphics CenterX="307.0" CenterY="261.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="319229"/> </DataNode> <DataNode TextLabel="Vipr1" GraphId="e74" Type="GeneProduct" GroupRef="ec598"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Vipr1"/> <Graphics CenterX="307.0" CenterY="317.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="22354"/> </DataNode> <DataNode TextLabel="Vipr2" GraphId="f83" Type="GeneProduct" GroupRef="ec598"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Vipr2"/> <Graphics CenterX="307.0" CenterY="337.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="22355"/> </DataNode> <DataNode TextLabel="Cd97" GraphId="c09" Type="GeneProduct" GroupRef="c601b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cd97"/> <Graphics CenterX="307.0" CenterY="409.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="26364"/> </DataNode> <DataNode TextLabel="Emr1" GraphId="c5e" Type="GeneProduct" GroupRef="c601b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Emr1"/> <Graphics CenterX="307.0" CenterY="429.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="13733"/> </DataNode> <DataNode TextLabel="Cd97" GraphId="e7c" Type="GeneProduct" GroupRef="c601b"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Cd97"/> <Graphics CenterX="307.0" CenterY="449.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="26364"/> </DataNode> <DataNode TextLabel="EMR2" GraphId="f53" Type="GeneProduct" GroupRef="c601b"> <Graphics CenterX="307.0" CenterY="469.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="" ID=""/> </DataNode> <DataNode TextLabel="Lphn1" GraphId="eac" Type="GeneProduct" GroupRef="fd1b2"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Lphn1"/> <Graphics CenterX="519.3333333333334" CenterY="157.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="330814"/> </DataNode> <DataNode TextLabel="Lphn2" GraphId="eb2" Type="GeneProduct" GroupRef="fd1b2"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Lphn2"/> <Graphics CenterX="519.3333333333334" CenterY="177.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="99633"/> </DataNode> <DataNode TextLabel="Lphn3" GraphId="d0b" Type="GeneProduct" GroupRef="fd1b2"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Lphn3"/> <Graphics CenterX="519.3333333333334" CenterY="197.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="319387"/> </DataNode> <DataNode TextLabel="Eltd1" GraphId="a0a" Type="GeneProduct" GroupRef="fd1b2"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Eltd1"/> <Graphics CenterX="519.3333333333334" CenterY="217.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="170757"/> </DataNode> <DataNode TextLabel="Gpr64" GraphId="c23" Type="GeneProduct"> <Attribute Key="org.pathvisio.model.BackpageHead" Value="Gpr64"/> <Graphics CenterX="518.3333333333334" CenterY="280.6666666666667" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/> <Xref Database="Entrez Gene" ID="237175"/> </DataNode> <Label TextLabel="Calcitonin" GraphId="afa"> <Graphics CenterX="96.0" CenterY="121.83333333333333" Width="54.333333333333336" Height="18.333333333333332" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Corticotropin releasing factor" GraphId="a2f"> <Graphics CenterX="96.0" CenterY="206.66666666666666" Width="148.33333333333334" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Gastric inhibitory peptide" GraphId="e79"> <Graphics CenterX="96.0" CenterY="287.6666666666667" Width="128.33333333333334" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Glucagon" GraphId="ae6"> <Graphics CenterX="96.0" CenterY="340.6666666666667" Width="52.333333333333336" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Growth hormone-releasing hormone" GraphId="ab3"> <Graphics CenterX="96.0" CenterY="448.8333333333333" Width="153.16666666666666" Height="10.333333333333334" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Parathyroid hormone" GraphId="d62"> <Graphics CenterX="308.0" CenterY="112.0" Width="107.33333333333333" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="PACAP" GraphId="a7a"> <Graphics CenterX="307.0" CenterY="194.0" Width="40.333333333333336" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Secretin" GraphId="a39"> <Graphics CenterX="307.0" CenterY="241.0" Width="46.333333333333336" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Vasoactive intestinal polypeptide" GraphId="af9"> <Graphics CenterX="307.0" CenterY="287.0" Width="168.33333333333334" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Diuretic hormone&#10;EMR1" GraphId="f1b"> <Graphics CenterX="307.0" CenterY="376.0" Width="89.33333333333333" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Latrophilin" GraphId="bc3"> <Graphics CenterX="518.3333333333334" CenterY="125.66666666666667" Width="57.333333333333336" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Label TextLabel="Class B orphan/other" GraphId="d1a"> <Graphics CenterX="518.3333333333334" CenterY="257.6666666666667" Width="108.33333333333333" Height="12.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="8" Valign="Middle"/> </Label> <Group GroupId="c601b" GraphId="a1051"/> <Group GroupId="ec598" GraphId="f23a8"/> <Group GroupId="a60b5" GraphId="f1bc1"/> <Group GroupId="a9b0a" GraphId="bcf31"/> <Group GroupId="b4223" GraphId="f2d8a"/> <Group GroupId="f02df" GraphId="d9dd5"/> <Group GroupId="fd1b2" GraphId="e318a"/> <InfoBox CenterX="5.1" CenterY="42.666666666666664"/> <Legend CenterX="341.3333333333333" CenterY="118.53333333333333"/> <Biopax> <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">G protein mediated signaling pathway</bp:TERM> <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000125</bp:ID> <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> </bp:openControlledVocabulary> </Biopax> </Pathway>

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