GPCRs, Class A Rhodopsin-like (Homo sapiens)

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CannabisAPJ likePlatelet activating factorGP40 likeMas proto-oncogene(Rhod)opsinRhodopsin VertebrateNeuropeptide YNucleotide-likeAdenosineBombesinORPHLGR like (hormone receptors)ChemokineC-C ChemokineThrombinNeuromedin UBONZO receptors (CXC6R)CCKClass A Orphan/otherPlatelet ADP & KI01 receptorsC-X-C ChemokineOpioidBeta AdrenoceptorsSREBSomatostatinAdrenoceptorsAlpha AdrenoceptorsAmineAcetylcholine (muscarinic)Chemokine receptor-likeVasopressin-likeHormone proteinFollicle stimulating hormoneAdrenomedullin (G10D)Other Chemokine ReceptorsRhodopsin OtherFmet-leu-pheClass A OrphansOlfactory OtherOrexin & neuropeptide FFEndothelinMelanocortinPurinoceptorsThyrotropin-releasing hormone and SecretagogueOlfactoryC5a anaphylatoxinLutropin-choriogonadotropic hormoneGPR45 likeNeuropeptide Y / peptide YYInterleukin-8Purinoceptor type YGPR75DRD4OXTROR2J3TRHROR7C2GPR85P2RY2RHOMC5RMAS1LAGTR1FPR1OR2J1NMUR2OR10H1CHRM5GPR63OR1A1CCRL2OPN1SWBDKRB2DRD3OR12D3OR1D5CNR2OR2D2OR3A2SSTR5ADRA1AGPR37ADORA2BAGTR2GPR17HCRTR2RRHOPN1MWCCR8HTR1BF2RL3SUCNR1CCRL1MLNRCCR7GPR174OR1I1OR1A2OPN4GPR74GALR2CCR9CCR6Angiotensin IIGPR15GPR41GPR37L1HRH2OR7A10OR2F2OR1D4CHRM4GPR22CCR4Q9UDD9GPR21GALR3MTNR1ACCR2CYSLTR1GPR30NTSR2GPR6OR1E1DRD1OR7C1FPRL1OR8D2P2RY14CMKOR1PTGIRIL8RBADRA1BOR2H2OPRD1HTR4FSHRGPR1HTR2BGPR35ADRA2AOR2W1HTR2AGHSRP2RY11P2RY4OPN1LWAVPR1ACCKBRHTR1DHRH1GPR42AVPR2OR1E2CCBP2OR10A5OR2C1BLR1CX3CR1BRS3LHCGRGPR19OR1C1PTGER1GPR27CMKLR1OR5U1CHRM1OR2B6C3AR1HistamineOPRK1PTGER2NTSR1MTNR1BOR1F1CHRM3DRD5NMUR1OR10J1OR11A1GPR10OR2A4GPR40MAS1CCR5GPR147ADRA2CGPR34GPR161NPY1RHTR7GPR24GPR18F2RL1GPR87LTB4RP2RY13GPR43GPR12CCR1RgrCXCR3OR2N1POPN3HTR5AAVPR1BGPR8GPR45CXCR4GPR31HCRTR1MC2RHTR6P2RY5GPR81PTGER4HTR2CSSTR2ADRB1BDKRB1PTGDRCYSLTR2PPYR1DopamineBradykininMelatoninOR2B2GPR109BGPR23GPR39F2RL2OR2AG1OR2B3GPR83PTGFRMC3ROR3A4ADORA2AGRPRDRD2EDNRAGPR77ADRB3IL8RAADORA1MC4RNPY5RP2RY10TBXA2ROR10A4OR1Q1P2RY12GPR4OR10H3CNR1GPR25OR6B1OR2F1SSTR3SSTR1NPY2RCCR3HRH3OPRL1HTR1EPTGER3OR10H2GALR1OR3A1GPR3OR8B8FPRL2SSTR4GPR7OR7A17OR2J2NMBRCCR10OPRM1OR5I1HTR1FEDNRBOR5F1MC1RF2RADRA1DOR2S2OR6A2OR1D2GPR92ADRA2BGPR68OR2H1P2RY6GPR32CCKARGPR171GPR173ADRB2OR3A3OR2T1SerotoninADORA3GPR20AGTRL1GPR50GPR65GPR52ProstaglandinOR7A5OR1G1HTR1AGPR44CHRM2P2RY1XCR1NPY6RPTAFROR5V1


Description

This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.

Quality Tags

Ontology Terms

 

Bibliography

  1. Karchin R, Karplus K, Haussler D; ''Classifying G-protein coupled receptors with support vector machines.''; Bioinformatics, 2002 PubMed Europe PMC
  2. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G; ''GPCRDB: an information system for G protein-coupled receptors.''; Nucleic Acids Res, 1998 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106426view23:19, 28 August 2019KhanspersModified description
106193view12:08, 16 August 2019MaintBotHMDB identifier normalization
105602view04:50, 10 August 2019KhanspersModified description
96878view21:57, 17 April 2018AlexanderPicobumping version for new png
81793view06:46, 28 August 2015MaintBotFixed weird characters in autors names.
79996view21:45, 29 April 2015Zari
79717view08:43, 6 April 2015EgonwAdded the two references cited in the Description.
79712view08:33, 6 April 2015EgonwModified description
78510view10:29, 7 January 2015MaintBotadded missing graphIds
74420view13:10, 18 April 2014EgonwMarked a metabolite as a DataNode type="Metabolite"...
74414view10:58, 18 April 2014EgonwAdded two interactions.
74413view10:55, 18 April 2014EgonwConverted two labels into metabolite DataNodes with an identifier.
71256view21:09, 16 October 2013MaintBotAutomated update of data sources
63203view20:55, 8 May 2013MaintBotUpdating gpml version
62691view21:33, 1 May 2013MaintBotupdated uniprot data source
45338view20:22, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway' added !
41121view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
38917view20:53, 24 September 2010Khanspers
34571view22:02, 21 December 2009KhanspersModified description
34540view19:20, 21 December 2009KhanspersModified description
34539view19:19, 21 December 2009Khansperslayout
34538view19:18, 21 December 2009KhanspersLayout
34537view19:13, 21 December 2009KhanspersPeriodical save, work in progress
34536view19:02, 21 December 2009KhanspersModified description
34474view18:35, 10 December 2009MaintBotAutomatic update of empty xrefs
32436view17:15, 15 August 2009MaintBotFixed text labels
32106view13:47, 14 August 2009MaintBotFixed group labels
21638view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:GPCRDB Class A Rhodopsin-like]] moved to [[Pathway:WP455]]: Moved to stable identifier
14501view00:54, 23 May 2008AlexanderPicoConnected ligands
14196view01:00, 22 May 2008AlexanderPicoFixed labels
14194view00:48, 22 May 2008AlexanderPicoPeriodical save, work in progress
14191view00:43, 22 May 2008AlexanderPicogrouped by class
13077view11:13, 17 May 2008MaintBotautomated metabolite conversion
12975view10:58, 17 May 2008MaintBotSticky edges patch by Sjoerd
8102view13:46, 7 January 2008MaintBot[[Pathway:Human:GPCRDB Class A Rhodopsin-like]] moved to [[Pathway:Homo sapiens:GPCRDB Class A Rhodopsin-like]]: Renaming species
7673view16:08, 18 December 2007MaintBotfixed category names
7416view12:42, 4 November 2007MaintBotAdded categories to GPML
19485view22:17, 22 May 2007BruceConklingpml file for [[Human:GPCRDB_Class_A_Rhodopsin-like]]
6321view22:17, 22 May 2007Nsalomonisgpml file for [[Human:GPCRDB_Class_A_Rhodopsin-like]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADORA1GeneProduct134 (Entrez Gene)
ADORA2AGeneProduct135 (Entrez Gene)
ADORA2BGeneProduct136 (Entrez Gene)
ADORA3GeneProduct140 (Entrez Gene)
ADRA1AGeneProduct148 (Entrez Gene)
ADRA1BGeneProduct147 (Entrez Gene)
ADRA1DGeneProduct146 (Entrez Gene)
ADRA2AGeneProduct150 (Entrez Gene)
ADRA2BGeneProduct151 (Entrez Gene)
ADRA2CGeneProduct152 (Entrez Gene)
ADRB1GeneProduct153 (Entrez Gene)
ADRB2GeneProduct154 (Entrez Gene)
ADRB3GeneProduct155 (Entrez Gene)
AGTR1GeneProduct185 (Entrez Gene)
AGTR2GeneProduct186 (Entrez Gene)
AGTRL1GeneProduct187 (Entrez Gene)
AVPR1AGeneProduct552 (Entrez Gene)
AVPR1BGeneProduct553 (Entrez Gene)
AVPR2GeneProduct554 (Entrez Gene)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
BDKRB1GeneProduct623 (Entrez Gene)
BDKRB2GeneProduct624 (Entrez Gene)
BLR1GeneProduct643 (Entrez Gene)
BRS3GeneProduct680 (Entrez Gene)
BradykininMetabolite58-82-2 (CAS)
C3AR1GeneProduct719 (Entrez Gene)
CCBP2GeneProduct1238 (Entrez Gene)
CCKARGeneProduct886 (Entrez Gene)
CCKBRGeneProduct887 (Entrez Gene)
CCR10GeneProduct2826 (Entrez Gene)
CCR1GeneProduct1230 (Entrez Gene)
CCR2GeneProduct1231 (Entrez Gene)
CCR3GeneProduct1232 (Entrez Gene)
CCR4GeneProduct1233 (Entrez Gene)
CCR5GeneProduct1234 (Entrez Gene)
CCR6GeneProduct1235 (Entrez Gene)
CCR7GeneProduct1236 (Entrez Gene)
CCR8GeneProduct1237 (Entrez Gene)
CCR9GeneProduct10803 (Entrez Gene)
CCRL1GeneProduct51554 (Entrez Gene)
CCRL2GeneProduct9034 (Entrez Gene)
CHRM1GeneProduct1128 (Entrez Gene)
CHRM2GeneProduct1129 (Entrez Gene)
CHRM3GeneProduct1131 (Entrez Gene)
CHRM4GeneProduct1132 (Entrez Gene)
CHRM5GeneProduct1133 (Entrez Gene)
CMKLR1GeneProduct1240 (Entrez Gene)
CMKOR1GeneProduct57007 (Entrez Gene)
CNR1GeneProduct1268 (Entrez Gene)
CNR2GeneProduct1269 (Entrez Gene)
CX3CR1GeneProduct1524 (Entrez Gene)
CXCR3GeneProduct2833 (Entrez Gene)
CXCR4GeneProduct7852 (Entrez Gene)
CYSLTR1GeneProduct10800 (Entrez Gene)
CYSLTR2GeneProduct57105 (Entrez Gene)
DRD1GeneProduct1812 (Entrez Gene)
DRD2GeneProduct1813 (Entrez Gene)
DRD3GeneProduct1814 (Entrez Gene)
DRD4GeneProduct1815 (Entrez Gene)
DRD5GeneProduct1816 (Entrez Gene)
DopamineMetabolite62-31-7 (CAS)
EDNRAGeneProduct1909 (Entrez Gene)
EDNRBGeneProduct1910 (Entrez Gene)
F2RGeneProduct2149 (Entrez Gene)
F2RL1GeneProduct2150 (Entrez Gene)
F2RL2GeneProduct2151 (Entrez Gene)
F2RL3GeneProduct9002 (Entrez Gene)
FPR1GeneProduct2357 (Entrez Gene)
FPRL1GeneProduct2358 (Entrez Gene)
FPRL2GeneProduct2359 (Entrez Gene)
FSHRGeneProduct2492 (Entrez Gene)
GALR1GeneProduct2587 (Entrez Gene)
GALR2GeneProduct8811 (Entrez Gene)
GALR3GeneProduct8484 (Entrez Gene)
GHSRGeneProduct2693 (Entrez Gene)
GPR10GeneProduct2834 (Entrez Gene)
GPR109BGeneProduct8843 (Entrez Gene)
GPR12GeneProduct2835 (Entrez Gene)
GPR1GeneProduct2825 (Entrez Gene)
GPR147GeneProduct64106 (Entrez Gene)
GPR15GeneProduct2838 (Entrez Gene)
GPR161GeneProduct23432 (Entrez Gene)
GPR171GeneProduct29909 (Entrez Gene)
GPR17GeneProduct2840 (Entrez Gene)
GPR173GeneProduct54328 (Entrez Gene)
GPR174GeneProduct84636 (Entrez Gene)
GPR18GeneProduct2841 (Entrez Gene)
GPR19GeneProduct2842 (Entrez Gene)
GPR20GeneProduct2843 (Entrez Gene)
GPR21GeneProduct2844 (Entrez Gene)
GPR22GeneProduct2845 (Entrez Gene)
GPR23GeneProduct2846 (Entrez Gene)
GPR24GeneProduct2847 (Entrez Gene)
GPR25GeneProduct2848 (Entrez Gene)
GPR27GeneProduct2850 (Entrez Gene)
GPR30GeneProduct2852 (Entrez Gene)
GPR31GeneProduct2853 (Entrez Gene)
GPR32GeneProduct2854 (Entrez Gene)
GPR3GeneProduct2827 (Entrez Gene)
GPR34GeneProduct2857 (Entrez Gene)
GPR35GeneProduct2859 (Entrez Gene)
GPR37GeneProduct2861 (Entrez Gene)
GPR37L1GeneProduct9283 (Entrez Gene)
GPR39GeneProduct2863 (Entrez Gene)
GPR40GeneProduct2864 (Entrez Gene)
GPR41GeneProduct2865 (Entrez Gene)
GPR42GeneProduct2866 (Entrez Gene)
GPR4GeneProduct2828 (Entrez Gene)
GPR43GeneProduct2867 (Entrez Gene)
GPR44GeneProduct11251 (Entrez Gene)
GPR45GeneProduct11250 (Entrez Gene)
GPR50GeneProduct9248 (Entrez Gene)
GPR52GeneProduct9293 (Entrez Gene)
GPR6GeneProduct2830 (Entrez Gene)
GPR63GeneProduct81491 (Entrez Gene)
GPR65GeneProduct8477 (Entrez Gene)
GPR68GeneProduct8111 (Entrez Gene)
GPR7GeneProduct2831 (Entrez Gene)
GPR74GeneProduct10886 (Entrez Gene)
GPR75GeneProduct10936 (Entrez Gene)
GPR77GeneProduct27202 (Entrez Gene)
GPR81GeneProduct27198 (Entrez Gene)
GPR8GeneProduct2832 (Entrez Gene)
GPR83GeneProduct10888 (Entrez Gene)
GPR85GeneProduct54329 (Entrez Gene)
GPR87GeneProduct53836 (Entrez Gene)
GPR92GeneProduct57121 (Entrez Gene)
GRPRGeneProduct2925 (Entrez Gene)
HCRTR1GeneProduct3061 (Entrez Gene)
HCRTR2GeneProduct3062 (Entrez Gene)
HRH1GeneProduct3269 (Entrez Gene)
HRH2GeneProduct3274 (Entrez Gene)
HRH3GeneProduct11255 (Entrez Gene)
HTR1AGeneProduct3350 (Entrez Gene)
HTR1BGeneProduct3351 (Entrez Gene)
HTR1DGeneProduct3352 (Entrez Gene)
HTR1EGeneProduct3354 (Entrez Gene)
HTR1FGeneProduct3355 (Entrez Gene)
HTR2AGeneProduct3356 (Entrez Gene)
HTR2BGeneProduct3357 (Entrez Gene)
HTR2CGeneProduct3358 (Entrez Gene)
HTR4GeneProduct3360 (Entrez Gene)
HTR5AGeneProduct3361 (Entrez Gene)
HTR6GeneProduct3362 (Entrez Gene)
HTR7GeneProduct3363 (Entrez Gene)
HistamineMetabolite51-45-6 (CAS)
IL8RAGeneProduct3577 (Entrez Gene)
IL8RBGeneProduct3579 (Entrez Gene)
LHCGRGeneProduct3973 (Entrez Gene)
LTB4RGeneProduct1241 (Entrez Gene)
MAS1GeneProduct4142 (Entrez Gene)
MAS1LGeneProduct116511 (Entrez Gene)
MC1RGeneProduct4157 (Entrez Gene)
MC2RGeneProduct4158 (Entrez Gene)
MC3RGeneProduct4159 (Entrez Gene)
MC4RGeneProduct4160 (Entrez Gene)
MC5RGeneProduct4161 (Entrez Gene)
MLNRGeneProduct2862 (Entrez Gene)
MTNR1AGeneProduct4543 (Entrez Gene)
MTNR1BGeneProduct4544 (Entrez Gene)
MelatoninMetaboliteHMDB01389 (HMDB)
NMBRGeneProduct4829 (Entrez Gene)
NMUR1GeneProduct10316 (Entrez Gene)
NMUR2GeneProduct56923 (Entrez Gene)
NPY1RGeneProduct4886 (Entrez Gene)
NPY2RGeneProduct4887 (Entrez Gene)
NPY5RGeneProduct4889 (Entrez Gene)
NPY6RGeneProduct4888 (Entrez Gene)
NTSR1GeneProduct4923 (Entrez Gene)
NTSR2GeneProduct23620 (Entrez Gene)
OPN1LWGeneProduct5956 (Entrez Gene)
OPN1MWGeneProduct2652 (Entrez Gene)
OPN1SWGeneProduct611 (Entrez Gene)
OPN3GeneProduct23596 (Entrez Gene)
OPN4GeneProduct94233 (Entrez Gene)
OPRD1GeneProduct4985 (Entrez Gene)
OPRK1GeneProduct4986 (Entrez Gene)
OPRL1GeneProduct4987 (Entrez Gene)
OPRM1GeneProduct4988 (Entrez Gene)
OR10A4GeneProduct283297 (Entrez Gene)
OR10A5GeneProduct144124 (Entrez Gene)
OR10H1GeneProduct26539 (Entrez Gene)
OR10H2GeneProduct26538 (Entrez Gene)
OR10H3GeneProduct26532 (Entrez Gene)
OR10J1GeneProduct26476 (Entrez Gene)
OR11A1GeneProduct26531 (Entrez Gene)
OR12D3GeneProduct81797 (Entrez Gene)
OR1A1GeneProduct8383 (Entrez Gene)
OR1A2GeneProduct26189 (Entrez Gene)
OR1C1GeneProduct26188 (Entrez Gene)
OR1D2GeneProduct4991 (Entrez Gene)
OR1D4GeneProduct8385 (Entrez Gene)
OR1D5GeneProduct8386 (Entrez Gene)
OR1E1GeneProduct8387 (Entrez Gene)
OR1E2GeneProduct8388 (Entrez Gene)
OR1F1GeneProduct4992 (Entrez Gene)
OR1G1GeneProduct8390 (Entrez Gene)
OR1I1GeneProduct126370 (Entrez Gene)
OR1Q1GeneProduct158131 (Entrez Gene)
OR2A4GeneProduct79541 (Entrez Gene)
OR2AG1GeneProduct144125 (Entrez Gene)
OR2B2GeneProduct81697 (Entrez Gene)
OR2B3GeneProduct442184 (Entrez Gene)
OR2B6GeneProduct26212 (Entrez Gene)
OR2C1GeneProduct4993 (Entrez Gene)
OR2D2GeneProduct120776 (Entrez Gene)
OR2F1GeneProduct26211 (Entrez Gene)
OR2F2GeneProduct135948 (Entrez Gene)
OR2H1GeneProduct26716 (Entrez Gene)
OR2H2GeneProduct7932 (Entrez Gene)
OR2J1GeneProduct442185 (Entrez Gene)
OR2J2GeneProduct26707 (Entrez Gene)
OR2J3GeneProduct442186 (Entrez Gene)
OR2N1PGeneProduct26701 (Entrez Gene)
OR2S2GeneProduct56656 (Entrez Gene)
OR2T1GeneProduct26696 (Entrez Gene)
OR2W1GeneProduct26692 (Entrez Gene)
OR3A1GeneProduct4994 (Entrez Gene)
OR3A2GeneProduct4995 (Entrez Gene)
OR3A3GeneProduct8392 (Entrez Gene)
OR3A4GeneProduct390756 (Entrez Gene)
OR5F1GeneProduct338674 (Entrez Gene)
OR5I1GeneProduct10798 (Entrez Gene)
OR5U1GeneProduct442191 (Entrez Gene)
OR5V1GeneProduct81696 (Entrez Gene)
OR6A2GeneProduct8590 (Entrez Gene)
OR6B1GeneProduct135946 (Entrez Gene)
OR7A10GeneProduct390892 (Entrez Gene)
OR7A17GeneProduct26333 (Entrez Gene)
OR7A5GeneProduct26659 (Entrez Gene)
OR7C1GeneProduct26664 (Entrez Gene)
OR7C2GeneProduct26658 (Entrez Gene)
OR8B8GeneProduct26493 (Entrez Gene)
OR8D2GeneProduct283160 (Entrez Gene)
OXTRGeneProduct5021 (Entrez Gene)
OpioidMetaboliteCHEBI:60598 (ChEBI)
P2RY10GeneProduct27334 (Entrez Gene)
P2RY11GeneProduct5032 (Entrez Gene)
P2RY12GeneProduct64805 (Entrez Gene)
P2RY13GeneProduct53829 (Entrez Gene)
P2RY14GeneProduct9934 (Entrez Gene)
P2RY1GeneProduct5028 (Entrez Gene)
P2RY2GeneProduct5029 (Entrez Gene)
P2RY4GeneProduct5030 (Entrez Gene)
P2RY5GeneProduct10161 (Entrez Gene)
P2RY6GeneProduct5031 (Entrez Gene)
PPYR1GeneProduct5540 (Entrez Gene)
PTAFRGeneProduct5724 (Entrez Gene)
PTGDRGeneProduct5729 (Entrez Gene)
PTGER1GeneProduct5731 (Entrez Gene)
PTGER2GeneProduct5732 (Entrez Gene)
PTGER3GeneProduct5733 (Entrez Gene)
PTGER4GeneProduct5734 (Entrez Gene)
PTGFRGeneProduct5737 (Entrez Gene)
PTGIRGeneProduct5739 (Entrez Gene)
ProstaglandinMetabolite745-65-3 (CAS)
Q9UDD9GeneProductQ9UDD9 (Uniprot-TrEMBL)
RHOGeneProduct6010 (Entrez Gene)
RRHGeneProduct10692 (Entrez Gene)
RgrGeneProduct266747 (Entrez Gene)
SSTR1GeneProduct6751 (Entrez Gene)
SSTR2GeneProduct6752 (Entrez Gene)
SSTR3GeneProduct6753 (Entrez Gene)
SSTR4GeneProduct6754 (Entrez Gene)
SSTR5GeneProduct6755 (Entrez Gene)
SUCNR1GeneProduct56670 (Entrez Gene)
SerotoninMetabolite50-67-9 (CAS)
SomatostatinMetaboliteCHEBI:64628 (ChEBI)
TBXA2RGeneProduct6915 (Entrez Gene)
TRHRGeneProduct7201 (Entrez Gene)
XCR1GeneProduct2829 (Entrez Gene)

Annotated Interactions

No annotated interactions

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