GPCRs, Class A Rhodopsin-like (Homo sapiens)

From WikiPathways

Revision as of 04:50, 10 August 2019 by Khanspers (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

Description

This pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. This pathway is part the CPTAC Assay Portal.

Quality Tags

Ontology Terms

Bibliography

Karchin R, Karplus K, Haussler D; ''Classifying G-protein coupled receptors with support vector machines.''; Bioinformatics, 2002 PubMed Europe PMC
Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G; ''GPCRDB: an information system for G protein-coupled receptors.''; Nucleic Acids Res, 1998 PubMed Europe PMC

History

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Revision	Action	Time	User	Comment
106426	view	23:19, 28 August 2019	Khanspers	Modified description
106193	view	12:08, 16 August 2019	MaintBot	HMDB identifier normalization
105602	view	04:50, 10 August 2019	Khanspers	Modified description
96878	view	21:57, 17 April 2018	AlexanderPico	bumping version for new png
81793	view	06:46, 28 August 2015	MaintBot	Fixed weird characters in autors names.
79996	view	21:45, 29 April 2015	Zari
79717	view	08:43, 6 April 2015	Egonw	Added the two references cited in the Description.
79712	view	08:33, 6 April 2015	Egonw	Modified description
78510	view	10:29, 7 January 2015	MaintBot	added missing graphIds
74420	view	13:10, 18 April 2014	Egonw	Marked a metabolite as a DataNode type="Metabolite"...
74414	view	10:58, 18 April 2014	Egonw	Added two interactions.
74413	view	10:55, 18 April 2014	Egonw	Converted two labels into metabolite DataNodes with an identifier.
71256	view	21:09, 16 October 2013	MaintBot	Automated update of data sources
63203	view	20:55, 8 May 2013	MaintBot	Updating gpml version
62691	view	21:33, 1 May 2013	MaintBot	updated uniprot data source
45338	view	20:22, 7 October 2011	AlexanderPico	Ontology Term : 'G protein mediated signaling pathway' added !
41121	view	23:37, 1 March 2011	MaintBot	Removed redundant pathway information and comments
38917	view	20:53, 24 September 2010	Khanspers
34571	view	22:02, 21 December 2009	Khanspers	Modified description
34540	view	19:20, 21 December 2009	Khanspers	Modified description
34539	view	19:19, 21 December 2009	Khanspers	layout
34538	view	19:18, 21 December 2009	Khanspers	Layout
34537	view	19:13, 21 December 2009	Khanspers	Periodical save, work in progress
34536	view	19:02, 21 December 2009	Khanspers	Modified description
34474	view	18:35, 10 December 2009	MaintBot	Automatic update of empty xrefs
32436	view	17:15, 15 August 2009	MaintBot	Fixed text labels
32106	view	13:47, 14 August 2009	MaintBot	Fixed group labels
21638	view	11:32, 14 November 2008	MaintBot	[[Pathway:Homo sapiens:GPCRDB Class A Rhodopsin-like]] moved to [[Pathway:WP455]]: Moved to stable identifier
14501	view	00:54, 23 May 2008	AlexanderPico	Connected ligands
14196	view	01:00, 22 May 2008	AlexanderPico	Fixed labels
14194	view	00:48, 22 May 2008	AlexanderPico	Periodical save, work in progress
14191	view	00:43, 22 May 2008	AlexanderPico	grouped by class
13077	view	11:13, 17 May 2008	MaintBot	automated metabolite conversion
12975	view	10:58, 17 May 2008	MaintBot	Sticky edges patch by Sjoerd
8102	view	13:46, 7 January 2008	MaintBot	[[Pathway:Human:GPCRDB Class A Rhodopsin-like]] moved to [[Pathway:Homo sapiens:GPCRDB Class A Rhodopsin-like]]: Renaming species
7673	view	16:08, 18 December 2007	MaintBot	fixed category names
7416	view	12:42, 4 November 2007	MaintBot	Added categories to GPML
19485	view	22:17, 22 May 2007	BruceConklin	gpml file for [[Human:GPCRDB_Class_A_Rhodopsin-like]]
6321	view	22:17, 22 May 2007	Nsalomonis	gpml file for [[Human:GPCRDB_Class_A_Rhodopsin-like]]

External references

DataNodes

View all...

Name	Type	Database reference
ADORA1	GeneProduct	134 (Entrez Gene)
ADORA2A	GeneProduct	135 (Entrez Gene)
ADORA2B	GeneProduct	136 (Entrez Gene)
ADORA3	GeneProduct	140 (Entrez Gene)
ADRA1A	GeneProduct	148 (Entrez Gene)
ADRA1B	GeneProduct	147 (Entrez Gene)
ADRA1D	GeneProduct	146 (Entrez Gene)
ADRA2A	GeneProduct	150 (Entrez Gene)
ADRA2B	GeneProduct	151 (Entrez Gene)
ADRA2C	GeneProduct	152 (Entrez Gene)
ADRB1	GeneProduct	153 (Entrez Gene)
ADRB2	GeneProduct	154 (Entrez Gene)
ADRB3	GeneProduct	155 (Entrez Gene)
AGTR1	GeneProduct	185 (Entrez Gene)
AGTR2	GeneProduct	186 (Entrez Gene)
AGTRL1	GeneProduct	187 (Entrez Gene)
AVPR1A	GeneProduct	552 (Entrez Gene)
AVPR1B	GeneProduct	553 (Entrez Gene)
AVPR2	GeneProduct	554 (Entrez Gene)
Angiotensin II	Metabolite	HMDB01035 (HMDB)
BDKRB1	GeneProduct	623 (Entrez Gene)
BDKRB2	GeneProduct	624 (Entrez Gene)
BLR1	GeneProduct	643 (Entrez Gene)
BRS3	GeneProduct	680 (Entrez Gene)
Bradykinin	Metabolite	58-82-2 (CAS)
C3AR1	GeneProduct	719 (Entrez Gene)
CCBP2	GeneProduct	1238 (Entrez Gene)
CCKAR	GeneProduct	886 (Entrez Gene)
CCKBR	GeneProduct	887 (Entrez Gene)
CCR10	GeneProduct	2826 (Entrez Gene)
CCR1	GeneProduct	1230 (Entrez Gene)
CCR2	GeneProduct	729230 (Entrez Gene)
CCR3	GeneProduct	1232 (Entrez Gene)
CCR4	GeneProduct	1233 (Entrez Gene)
CCR5	GeneProduct	1234 (Entrez Gene)
CCR6	GeneProduct	1235 (Entrez Gene)
CCR7	GeneProduct	1236 (Entrez Gene)
CCR8	GeneProduct	1237 (Entrez Gene)
CCR9	GeneProduct	10803 (Entrez Gene)
CCRL1	GeneProduct	51554 (Entrez Gene)
CCRL2	GeneProduct	9034 (Entrez Gene)
CHRM1	GeneProduct	1128 (Entrez Gene)
CHRM2	GeneProduct	1129 (Entrez Gene)
CHRM3	GeneProduct	1131 (Entrez Gene)
CHRM4	GeneProduct	1132 (Entrez Gene)
CHRM5	GeneProduct	1133 (Entrez Gene)
CMKLR1	GeneProduct	1240 (Entrez Gene)
CMKOR1	GeneProduct	57007 (Entrez Gene)
CNR1	GeneProduct	1268 (Entrez Gene)
CNR2	GeneProduct	1269 (Entrez Gene)
CX3CR1	GeneProduct	1524 (Entrez Gene)
CXCR3	GeneProduct	2833 (Entrez Gene)
CXCR4	GeneProduct	7852 (Entrez Gene)
CYSLTR1	GeneProduct	10800 (Entrez Gene)
CYSLTR2	GeneProduct	57105 (Entrez Gene)
DRD1	GeneProduct	1812 (Entrez Gene)
DRD2	GeneProduct	1813 (Entrez Gene)
DRD3	GeneProduct	1814 (Entrez Gene)
DRD4	GeneProduct	1815 (Entrez Gene)
DRD5	GeneProduct	1816 (Entrez Gene)
Dopamine	Metabolite	62-31-7 (CAS)
EDNRA	GeneProduct	1909 (Entrez Gene)
EDNRB	GeneProduct	1910 (Entrez Gene)
F2R	GeneProduct	2149 (Entrez Gene)
F2RL1	GeneProduct	2150 (Entrez Gene)
F2RL2	GeneProduct	2151 (Entrez Gene)
F2RL3	GeneProduct	9002 (Entrez Gene)
FPR1	GeneProduct	2357 (Entrez Gene)
FPRL1	GeneProduct	2358 (Entrez Gene)
FPRL2	GeneProduct	2359 (Entrez Gene)
FSHR	GeneProduct	2492 (Entrez Gene)
GALR1	GeneProduct	2587 (Entrez Gene)
GALR2	GeneProduct	8811 (Entrez Gene)
GALR3	GeneProduct	8484 (Entrez Gene)
GHSR	GeneProduct	2693 (Entrez Gene)
GPR10	GeneProduct	2834 (Entrez Gene)
GPR109B	GeneProduct	8843 (Entrez Gene)
GPR12	GeneProduct	2835 (Entrez Gene)
GPR1	GeneProduct	2825 (Entrez Gene)
GPR147	GeneProduct	64106 (Entrez Gene)
GPR15	GeneProduct	2838 (Entrez Gene)
GPR161	GeneProduct	23432 (Entrez Gene)
GPR171	GeneProduct	29909 (Entrez Gene)
GPR17	GeneProduct	2840 (Entrez Gene)
GPR173	GeneProduct	54328 (Entrez Gene)
GPR174	GeneProduct	84636 (Entrez Gene)
GPR18	GeneProduct	2841 (Entrez Gene)
GPR19	GeneProduct	2842 (Entrez Gene)
GPR20	GeneProduct	2843 (Entrez Gene)
GPR21	GeneProduct	2844 (Entrez Gene)
GPR22	GeneProduct	2845 (Entrez Gene)
GPR23	GeneProduct	2846 (Entrez Gene)
GPR24	GeneProduct	2847 (Entrez Gene)
GPR25	GeneProduct	2848 (Entrez Gene)
GPR27	GeneProduct	2850 (Entrez Gene)
GPR30	GeneProduct	2852 (Entrez Gene)
GPR31	GeneProduct	2853 (Entrez Gene)
GPR32	GeneProduct	2854 (Entrez Gene)
GPR3	GeneProduct	2827 (Entrez Gene)
GPR34	GeneProduct	2857 (Entrez Gene)
GPR35	GeneProduct	2859 (Entrez Gene)
GPR37	GeneProduct	2861 (Entrez Gene)
GPR37L1	GeneProduct	9283 (Entrez Gene)
GPR39	GeneProduct	2863 (Entrez Gene)
GPR40	GeneProduct	2864 (Entrez Gene)
GPR41	GeneProduct	2865 (Entrez Gene)
GPR42	GeneProduct	2866 (Entrez Gene)
GPR4	GeneProduct	2828 (Entrez Gene)
GPR43	GeneProduct	2867 (Entrez Gene)
GPR44	GeneProduct	11251 (Entrez Gene)
GPR45	GeneProduct	11250 (Entrez Gene)
GPR50	GeneProduct	9248 (Entrez Gene)
GPR52	GeneProduct	9293 (Entrez Gene)
GPR6	GeneProduct	2830 (Entrez Gene)
GPR63	GeneProduct	81491 (Entrez Gene)
GPR65	GeneProduct	8477 (Entrez Gene)
GPR68	GeneProduct	8111 (Entrez Gene)
GPR7	GeneProduct	2831 (Entrez Gene)
GPR74	GeneProduct	10886 (Entrez Gene)
GPR75	GeneProduct	10936 (Entrez Gene)
GPR77	GeneProduct	27202 (Entrez Gene)
GPR81	GeneProduct	27198 (Entrez Gene)
GPR8	GeneProduct	2832 (Entrez Gene)
GPR83	GeneProduct	10888 (Entrez Gene)
GPR85	GeneProduct	54329 (Entrez Gene)
GPR87	GeneProduct	53836 (Entrez Gene)
GPR92	GeneProduct	57121 (Entrez Gene)
GRPR	GeneProduct	2925 (Entrez Gene)
HCRTR1	GeneProduct	3061 (Entrez Gene)
HCRTR2	GeneProduct	3062 (Entrez Gene)
HRH1	GeneProduct	3269 (Entrez Gene)
HRH2	GeneProduct	3274 (Entrez Gene)
HRH3	GeneProduct	11255 (Entrez Gene)
HTR1A	GeneProduct	3350 (Entrez Gene)
HTR1B	GeneProduct	3351 (Entrez Gene)
HTR1D	GeneProduct	3352 (Entrez Gene)
HTR1E	GeneProduct	3354 (Entrez Gene)
HTR1F	GeneProduct	3355 (Entrez Gene)
HTR2A	GeneProduct	3356 (Entrez Gene)
HTR2B	GeneProduct	3357 (Entrez Gene)
HTR2C	GeneProduct	3358 (Entrez Gene)
HTR4	GeneProduct	3360 (Entrez Gene)
HTR5A	GeneProduct	3361 (Entrez Gene)
HTR6	GeneProduct	3362 (Entrez Gene)
HTR7	GeneProduct	3363 (Entrez Gene)
Histamine	Metabolite	51-45-6 (CAS)
IL8RA	GeneProduct	3577 (Entrez Gene)
IL8RB	GeneProduct	3579 (Entrez Gene)
LHCGR	GeneProduct	3973 (Entrez Gene)
LTB4R	GeneProduct	1241 (Entrez Gene)
MAS1	GeneProduct	4142 (Entrez Gene)
MAS1L	GeneProduct	116511 (Entrez Gene)
MC1R	GeneProduct	4157 (Entrez Gene)
MC2R	GeneProduct	4158 (Entrez Gene)
MC3R	GeneProduct	4159 (Entrez Gene)
MC4R	GeneProduct	4160 (Entrez Gene)
MC5R	GeneProduct	4161 (Entrez Gene)
MLNR	GeneProduct	2862 (Entrez Gene)
MTNR1A	GeneProduct	4543 (Entrez Gene)
MTNR1B	GeneProduct	4544 (Entrez Gene)
Melatonin	Metabolite	HMDB01389 (HMDB)
NMBR	GeneProduct	4829 (Entrez Gene)
NMUR1	GeneProduct	10316 (Entrez Gene)
NMUR2	GeneProduct	56923 (Entrez Gene)
NPY1R	GeneProduct	4886 (Entrez Gene)
NPY2R	GeneProduct	4887 (Entrez Gene)
NPY5R	GeneProduct	4889 (Entrez Gene)
NPY6R	GeneProduct	4888 (Entrez Gene)
NTSR1	GeneProduct	4923 (Entrez Gene)
NTSR2	GeneProduct	23620 (Entrez Gene)
OPN1LW	GeneProduct	5956 (Entrez Gene)
OPN1MW	GeneProduct	2652 (Entrez Gene)
OPN1SW	GeneProduct	611 (Entrez Gene)
OPN3	GeneProduct	23596 (Entrez Gene)
OPN4	GeneProduct	94233 (Entrez Gene)
OPRD1	GeneProduct	4985 (Entrez Gene)
OPRK1	GeneProduct	4986 (Entrez Gene)
OPRL1	GeneProduct	4987 (Entrez Gene)
OPRM1	GeneProduct	4988 (Entrez Gene)
OR10A4	GeneProduct	283297 (Entrez Gene)
OR10A5	GeneProduct	144124 (Entrez Gene)
OR10H1	GeneProduct	26539 (Entrez Gene)
OR10H2	GeneProduct	26538 (Entrez Gene)
OR10H3	GeneProduct	26532 (Entrez Gene)
OR10J1	GeneProduct	26476 (Entrez Gene)
OR11A1	GeneProduct	26531 (Entrez Gene)
OR12D3	GeneProduct	81797 (Entrez Gene)
OR1A1	GeneProduct	8383 (Entrez Gene)
OR1A2	GeneProduct	26189 (Entrez Gene)
OR1C1	GeneProduct	26188 (Entrez Gene)
OR1D2	GeneProduct	4991 (Entrez Gene)
OR1D4	GeneProduct	653166 (Entrez Gene)
OR1D5	GeneProduct	8386 (Entrez Gene)
OR1E1	GeneProduct	8387 (Entrez Gene)
OR1E2	GeneProduct	8388 (Entrez Gene)
OR1F1	GeneProduct	4992 (Entrez Gene)
OR1G1	GeneProduct	8390 (Entrez Gene)
OR1I1	GeneProduct	126370 (Entrez Gene)
OR1Q1	GeneProduct	158131 (Entrez Gene)
OR2A4	GeneProduct	79541 (Entrez Gene)
OR2AG1	GeneProduct	144125 (Entrez Gene)
OR2B2	GeneProduct	81697 (Entrez Gene)
OR2B3	GeneProduct	442184 (Entrez Gene)
OR2B6	GeneProduct	26212 (Entrez Gene)
OR2C1	GeneProduct	4993 (Entrez Gene)
OR2D2	GeneProduct	120776 (Entrez Gene)
OR2F1	GeneProduct	26211 (Entrez Gene)
OR2F2	GeneProduct	135948 (Entrez Gene)
OR2H1	GeneProduct	26716 (Entrez Gene)
OR2H2	GeneProduct	7932 (Entrez Gene)
OR2J1	GeneProduct	442185 (Entrez Gene)
OR2J2	GeneProduct	26707 (Entrez Gene)
OR2J3	GeneProduct	442186 (Entrez Gene)
OR2N1P	GeneProduct	26701 (Entrez Gene)
OR2S2	GeneProduct	56656 (Entrez Gene)
OR2T1	GeneProduct	26696 (Entrez Gene)
OR2W1	GeneProduct	26692 (Entrez Gene)
OR3A1	GeneProduct	4994 (Entrez Gene)
OR3A2	GeneProduct	4995 (Entrez Gene)
OR3A3	GeneProduct	8392 (Entrez Gene)
OR3A4	GeneProduct	390756 (Entrez Gene)
OR5F1	GeneProduct	338674 (Entrez Gene)
OR5I1	GeneProduct	10798 (Entrez Gene)
OR5U1	GeneProduct	442191 (Entrez Gene)
OR5V1	GeneProduct	81696 (Entrez Gene)
OR6A2	GeneProduct	8590 (Entrez Gene)
OR6B1	GeneProduct	135946 (Entrez Gene)
OR7A10	GeneProduct	390892 (Entrez Gene)
OR7A17	GeneProduct	26333 (Entrez Gene)
OR7A5	GeneProduct	26659 (Entrez Gene)
OR7C1	GeneProduct	26664 (Entrez Gene)
OR7C2	GeneProduct	26658 (Entrez Gene)
OR8B8	GeneProduct	26493 (Entrez Gene)
OR8D2	GeneProduct	283160 (Entrez Gene)
OXTR	GeneProduct	5021 (Entrez Gene)
Opioid	Metabolite	CHEBI:60598 (ChEBI)
P2RY10	GeneProduct	27334 (Entrez Gene)
P2RY11	GeneProduct	5032 (Entrez Gene)
P2RY12	GeneProduct	64805 (Entrez Gene)
P2RY13	GeneProduct	53829 (Entrez Gene)
P2RY14	GeneProduct	9934 (Entrez Gene)
P2RY1	GeneProduct	5028 (Entrez Gene)
P2RY2	GeneProduct	5029 (Entrez Gene)
P2RY4	GeneProduct	5030 (Entrez Gene)
P2RY5	GeneProduct	10161 (Entrez Gene)
P2RY6	GeneProduct	5031 (Entrez Gene)
PPYR1	GeneProduct	5540 (Entrez Gene)
PTAFR	GeneProduct	5724 (Entrez Gene)
PTGDR	GeneProduct	5729 (Entrez Gene)
PTGER1	GeneProduct	5731 (Entrez Gene)
PTGER2	GeneProduct	5732 (Entrez Gene)
PTGER3	GeneProduct	5733 (Entrez Gene)
PTGER4	GeneProduct	5734 (Entrez Gene)
PTGFR	GeneProduct	5737 (Entrez Gene)
PTGIR	GeneProduct	5739 (Entrez Gene)
Prostaglandin	Metabolite	745-65-3 (CAS)
Q9UDD9	GeneProduct	Q9UDD9 (Uniprot-TrEMBL)
RHO	GeneProduct	6010 (Entrez Gene)
RRH	GeneProduct	10692 (Entrez Gene)
Rgr	GeneProduct	266747 (Entrez Gene)
SSTR1	GeneProduct	6751 (Entrez Gene)
SSTR2	GeneProduct	6752 (Entrez Gene)
SSTR3	GeneProduct	6753 (Entrez Gene)
SSTR4	GeneProduct	6754 (Entrez Gene)
SSTR5	GeneProduct	6755 (Entrez Gene)
SUCNR1	GeneProduct	56670 (Entrez Gene)
Serotonin	Metabolite	50-67-9 (CAS)
Somatostatin	Metabolite	CHEBI:64628 (ChEBI)
TBXA2R	GeneProduct	6915 (Entrez Gene)
TRHR	GeneProduct	7201 (Entrez Gene)
XCR1	GeneProduct	2829 (Entrez Gene)

Annotated Interactions

No annotated interactions

GPCRs, Class A Rhodopsin-like (Homo sapiens)

From WikiPathways

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