The alternative pathway of fetal androgen synthesis (Homo sapiens)

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Dihydrotestosterone3β-HSD5α-reductase 1Testosterone17-HydroxypregnenolonePregnenoloneCholesterolP450c17POR3 HSD17β-HSDAndrostanediolRODHCytb5AndrostanedioneAKR1C2/417-HydroxyprogesteroneSTARDHEAP450sccAndrostenedione17-hydroxydihydroprogesterone17-HydroxyallopregnanoloneAndrosteroneProgesteroneAKR1C4PORP450c173β-HSD17β-HSD35α-reductase 2PORP450c17P450c17


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  1. Moore RJ, Griffin JE, Wilson JD; ''Diminished 5alpha-reductase activity in extracts of fibroblasts cultured from patients with familial incomplete male pseudohermaphroditism, type 2.''; J Biol Chem, 1975 PubMed Europe PMC
  2. Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY; ''Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase.''; Arch Biochem Biophys, 2001 PubMed Europe PMC
  3. Strushkevich N, MacKenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW; ''Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.''; Proc Natl Acad Sci U S A, 2011 PubMed Europe PMC
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  7. Fouad Mansour M, Pelletier M, Tchernof A; ''Characterization of 5α-reductase activity and isoenzymes in human abdominal adipose tissues.''; J Steroid Biochem Mol Biol, 2016 PubMed Europe PMC
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  11. Hanukoglu I, Spitsberg V, Bumpus JA, Dus KM, Jefcoate CR; ''Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover.''; J Biol Chem, 1981 PubMed Europe PMC
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  14. Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP; ''Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.''; J Biol Chem, 2016 PubMed Europe PMC
  15. Flück CE, Meyer-Böni M, Pandey AV, Kempná P, Miller WL, Schoenle EJ, Biason-Lauber A; ''Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation.''; Am J Hum Genet, 2011 PubMed Europe PMC
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  32. Burstein S, Middleditch BS, Gut M; ''Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical preparations. Mode of oxygen incorporation.''; J Biol Chem, 1975 PubMed Europe PMC


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108087view11:53, 28 November 2019FehrhartOntology Term : 'disease pathway' added !
106166view12:06, 16 August 2019MaintBotHMDB identifier normalization
104252view12:18, 12 May 2019EgonwRemoved the RHEA: prefix from the identifier.
104034view17:46, 25 April 2019IreneHemelModified description
103502view14:41, 6 March 2019DeSlAnother lit. ref. update
103501view14:40, 6 March 2019DeSlRemoved weird signs in lit. ref
103500view14:36, 6 March 2019DeSlAdded more lit. refs.
103498view14:25, 6 March 2019DeSlAdded more diseases to PW.
103452view21:40, 1 March 2019DeSlAdded several diseases to PW.
103369view13:37, 24 February 2019EgonwReplaced a secondary ChEBI ID with primary ID.
103281view13:15, 21 February 2019DeSlChanged conversion to modification fot POR catalysed reaction between protein nodes
103280view21:00, 20 February 2019DeSlOntology Term : 'steroid inherited metabolic disorder' added !
103279view20:58, 20 February 2019DeSlAnnotated missing protein Nodes.
103278view20:51, 20 February 2019DeSlAdded more Rheas for bottom left part.
103277view20:25, 20 February 2019DeSlAdded more Rhea Ids to the right bottom part
103274view17:28, 20 February 2019DeSlAnnotated some more reaction with Rhea (top part), added lit. refs, added first disease node.
103202view16:31, 15 February 2019DeSlModified description
103201view16:29, 15 February 2019DeSlAdded info for POR enzyme
103200view15:58, 15 February 2019DeSlChanged weird symbols to written alpha/beta for enzymes.
103197view15:43, 15 February 2019DeSlAnnotated left top side, added Rhea's, added lit. refs.
103195view15:27, 15 February 2019DeSlModified description
103194view15:27, 15 February 2019DeSlAdded first 2 lit refs
103193view15:23, 15 February 2019DeSlOntology Term : 'steroid hormone biosynthetic pathway' added !
103192view15:22, 15 February 2019DeSlOntology Term : 'altered isoprenoid biosynthetic pathway' added !
103191view15:21, 15 February 2019DeSlOntology Term : 'altered steroid biosynthetic pathway' added !
103190view15:20, 15 February 2019DeSlOntology Term : 'PW:0000752' removed !
103189view15:19, 15 February 2019DeSlOntology Term : 'altered cholesterol biosynthetic pathway' added !
103188view15:19, 15 February 2019DeSlOntology Term : 'steroid metabolic pathway' added !
103187view15:16, 15 February 2019DeSlOntology Term : 'cholesterol metabolic pathway' added !
103186view15:14, 15 February 2019DeSlOntology Term : 'steroid hormone metabolic pathway' added !
103184view15:12, 15 February 2019DeSlOntology Term : 'testosterone biosynthetic pathway' added !
103182view15:07, 15 February 2019DeSlModified description
103154view13:07, 15 February 2019ElineSandersNew pathway

External references


View all...
NameTypeDatabase referenceComment
17-HydroxyallopregnanoloneMetaboliteCHEBI:11909 (ChEBI)
17-HydroxypregnenoloneMetaboliteQ2064889 (Wikidata)
17-HydroxyprogesteroneMetaboliteHMDB00374 (HMDB)
17-hydroxydihydroprogesteroneMetaboliteCHEBI:36723 (ChEBI)
17β-HSD3GeneProductENSG00000130948 (Ensembl)
17β-HSDGeneProductENSG00000130948 (Ensembl)
3 HSDProtein
3β-HSDGeneProductENSG00000203859 (Ensembl)
5α-reductase 1GeneProductENSG00000277893 (Ensembl)
5α-reductase 2GeneProductENSG00000277893 (Ensembl)
AKR1C2/4GeneProductENSG00000151632 (Ensembl)
AKR1C4GeneProductENSG00000198610 (Ensembl)
AndrostanediolMetaboliteCHEBI:2713 (ChEBI)
AndrostanedioneMetaboliteCHEBI:2137 (ChEBI)
AndrostenedioneMetaboliteHMDB00053 (HMDB)
AndrosteroneMetaboliteCHEBI:2714 (ChEBI)
CholesterolMetaboliteCHEBI:3659 (ChEBI)
DHEAMetaboliteCHEBI:1723 (ChEBI)
DihydrotestosteroneMetaboliteCHEBI:41876 (ChEBI)
P450c17GeneProductENSG00000148795 (Ensembl)
P450sccGeneProductENSG00000140459 (Ensembl)
PregnenoloneMetaboliteCHEBI:16581 (ChEBI)
ProgesteroneMetaboliteCHEBI:45786 (ChEBI)
STARGeneProductENSG00000147465 (Ensembl)
TestosteroneMetaboliteCHEBI:45798 (ChEBI)

Annotated Interactions

No annotated interactions

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