Classical pathway of steroidogenesis, including diseases (Homo sapiens)
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Bibliography
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
11-Deoxycortisol | Metabolite | CHEBI:28324 (ChEBI) ![]() | |
11β-HSD1 | GeneProduct | ENSG00000117594 (Ensembl) ![]() | |
11β-HSD2 | GeneProduct | ENSG00000176387 (Ensembl) ![]() | |
17-Hydroxypregnenolone | Metabolite | Q2064889 (Wikidata) ![]() | |
17-Hydroxyprogesterone | Metabolite | HMDB00374 (HMDB) ![]() | |
17β-HSD3 | GeneProduct | ENSG00000130948 (Ensembl) ![]() | |
18-hydroxycorticosterone | Metabolite | CHEBI:16485 (ChEBI) ![]() | |
3β-HSD | GeneProduct | ENSG00000203859 (Ensembl) ![]() | |
5α-Reductase2 | GeneProduct | ENSG00000277893 (Ensembl) ![]() | |
Aldosterone | Metabolite | CHEBI:2563 (ChEBI) ![]() | |
Androstenedione | Metabolite | CHEBI:2709 (ChEBI) ![]() | |
Cholesterol | Metabolite | CHEBI:3659 (ChEBI) ![]() | |
Corticosterone Methyl Oxidase I | GeneProduct | ENSG00000179142 (Ensembl) ![]() | |
Corticosterone Methyl Oxidase II | GeneProduct | ENSG00000179142 (Ensembl) ![]() | |
Corticosterone | Metabolite | CHEBI:16827 (ChEBI) ![]() | |
Cortisol | Metabolite | CHEBI:3893 (ChEBI) ![]() | |
Cortisone | Metabolite | CHEBI:3896 (ChEBI) ![]() | |
Cytb5 | GeneProduct | ||
DHEA | Metabolite | CHEBI:1723 (ChEBI) ![]() | |
Deoxycorticosterone | Metabolite | HMDB00016 (HMDB) ![]() | |
Dihydrotestosterone | Metabolite | CHEBI:41876 (ChEBI) ![]() | |
H-6-PDH | Protein | ||
Oestradiol | Metabolite | CHEBI:16469 (ChEBI) ![]() | |
P450Aro | GeneProduct | ENSG00000137869 (Ensembl) ![]() | |
P450c11 | GeneProduct | ENSG00000160882 (Ensembl) ![]() | |
P450c17 | GeneProduct | ENSG00000148795 (Ensembl) ![]() | |
P450c21 | GeneProduct | ENSG00000231852 (Ensembl) ![]() | |
P450scc | GeneProduct | ENSG00000140459 (Ensembl) ![]() |
|
POR | Protein | ||
Pregnenolone | Metabolite | CHEBI:16581 (ChEBI) ![]() | |
Progesterone | Metabolite | CHEBI:8453 (ChEBI) ![]() | |
STAR | GeneProduct | ENSG00000147465 (Ensembl) ![]() | |
Testosterone | Metabolite | CHEBI:9461 (ChEBI) ![]() |
Annotated Interactions
Source | Target | Type | Database reference | Comment |
---|---|---|---|---|
11-Deoxycortisol | Cortisol | mim-conversion | RHEA:15630 (Rhea) ![]() | |
Corticosterone | 18-hydroxycorticosterone | mim-conversion | RHEA:11873 (Rhea) ![]() | |
Deoxycorticosterone | Corticosterone | mim-conversion | RHEA:15630 (Rhea) ![]() | |
Pregnenolone | Progesterone | mim-conversion | RHEA:43929 (Rhea) ![]() |