Cerebral Organic Acidurias, including diseases (Homo sapiens)
From WikiPathways
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<Comment Source="WikiPathways-description">This pathway shows disorders related to the accumulation of organic acids in body fluids, resulting in cerebral organic acidurias. Symptoms often include mental or motor retardation, difficulties while moving and epilepsy. For all but one disorder, current treatment options have been proven ineffective. Disorders resulting from an enzyme defect are highlighted in pink. This pathway was inspired by Chapter 8 of the book of Blau (ISBN 3642403360 (978-3642403361)).</Comment> | <Comment Source="WikiPathways-description">This pathway shows disorders related to the accumulation of organic acids in body fluids, resulting in cerebral organic acidurias. Symptoms often include mental or motor retardation, difficulties while moving and epilepsy. For all but one disorder, current treatment options have been proven ineffective. Disorders resulting from an enzyme defect are highlighted in pink. This pathway was inspired by Chapter 8 of the book of Blau (ISBN 3642403360 (978-3642403361)).</Comment> | ||
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<Comment>Aka ACY1</Comment> | <Comment>Aka ACY1</Comment> | ||
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</bp:openControlledVocabulary> | </bp:openControlledVocabulary> | ||
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- | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16602100</bp:ID> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
- | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glutaric acidemia type 1.</bp:TITLE> |
- | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Am J Med Genet C Semin Med Genet</bp:SOURCE> |
- | + | ||
- | + | ||
- | + | ||
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- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR> | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR> | ||
- | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hedlund GL</bp:AUTHORS> |
- | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Longo N</bp:AUTHORS> |
- | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pasquali M</bp:AUTHORS> |
</bp:PublicationXref> | </bp:PublicationXref> | ||
- | |||
- | |||
- | |||
- | |||
- | |||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e43"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e43"> | ||
- | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> ''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases'''</bp:TITLE> | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> ''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases'''</bp:TITLE> | ||
- | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE> |
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> | ||
- | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE> | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE> | ||
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(ISBN 978-3-642-40337-8)</bp:SOURCE> | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(ISBN 978-3-642-40337-8)</bp:SOURCE> | ||
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> | ||
- | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE> | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE> | ||
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-642-40337-8</bp:SOURCE> | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-642-40337-8</bp:SOURCE> | ||
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR> | ||
- | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/> | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE> | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE> | ||
Line 646: | Line 647: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dionisi-Vici</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dionisi-Vici</bp:AUTHORS> | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carlo</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carlo</bp:AUTHORS> | ||
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</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c79"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c79"> | ||
Line 687: | Line 678: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Salomons GS</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Salomons GS</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
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- | |||
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- | |||
- | |||
<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b39"> | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b39"> | ||
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7564239</bp:ID> | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7564239</bp:ID> | ||
Line 709: | Line 695: | ||
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Superti-Furga A</bp:AUTHORS> | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Superti-Furga A</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
- | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id=" | + | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eca"> |
- | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6774165</bp:ID> |
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
- | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D-2-hydroxyglutaric aciduria: case report and biochemical studies.</bp:TITLE> |
- | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Inherit Metab Dis</bp:SOURCE> |
- | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1980</bp:YEAR> |
- | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chalmers RA</bp:AUTHORS> |
- | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lawson AM</bp:AUTHORS> |
- | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watts RW</bp:AUTHORS> |
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tavill AS</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kamerling JP</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hey E</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ogilvie D</bp:AUTHORS> | ||
+ | </bp:PublicationXref> | ||
+ | <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d04"> | ||
+ | <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16005139</bp:ID> | ||
+ | <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | ||
+ | <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase.</bp:TITLE> | ||
+ | <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE> | ||
+ | <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rzem R</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Schaftingen E</bp:AUTHORS> | ||
+ | <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Veiga-da-Cunha M</bp:AUTHORS> | ||
</bp:PublicationXref> | </bp:PublicationXref> | ||
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | ||
Line 725: | Line 725: | ||
</bp:openControlledVocabulary> | </bp:openControlledVocabulary> | ||
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | ||
- | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glutaric aciduria type I pathway</bp:TERM> |
- | <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002306</bp:ID> |
- | <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> | + | <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology> |
</bp:openControlledVocabulary> | </bp:openControlledVocabulary> | ||
</Biopax> | </Biopax> | ||
</Pathway> | </Pathway> |
Revision as of 12:09, 16 August 2019
Error rendering pathway page
This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.
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Error details
exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/e/ec/WP4519_prev.svg: <BR>Status:1 <BR>Message:Exception in thread "main" java.lang.NullPointerException at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source) at org.pathvisio.core.Engine.importPathway(Unknown Source) at org.pathvisio.core.util.Converter.main(Unknown Source) <BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/e/ec/WP4519_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255 Stack trace: #0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...') #1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg') #2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg') #3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState)) #4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array) #5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array) #6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106202) #7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true) #8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true) #9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...') #10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision() #11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false) #12 /var/www/wikipathways/includes/Wiki.php(437): Article->view() #13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest)) #14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest)) #15 {main}