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This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

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Revision	Action	Time	User	Comment
106202	view	12:09, 16 August 2019	MaintBot	HMDB identifier normalization
104246	view	18:45, 11 May 2019	Egonw	Removed a copy/paste error.
104245	view	18:44, 11 May 2019	Egonw	Removed the RHEA: prefix from the identifier.
104031	view	17:43, 25 April 2019	IreneHemel	Modified description
103578	view	10:17, 18 March 2019	EviSchoenmaker	Layout adjustment
103563	view	09:55, 15 March 2019	BrittPieters	Changed gene product to proteins
103391	view	19:08, 25 February 2019	DeSl	Updated ID for N-acetylaspartate (was annotated with protein ID, not metabolite ID).
103389	view	15:33, 25 February 2019	DeSl	Removed weird signs in lit. ref
103317	view	09:15, 22 February 2019	BrittPieters	Test for CHEBI adaptations
103253	view	15:27, 18 February 2019	BrittPieters	Added Antiquitin
103246	view	10:27, 18 February 2019	BrittPieters	Changes in Rhea ID
103241	view	09:49, 18 February 2019	BrittPieters	Change Rhea ID
103231	view	08:53, 18 February 2019	BrittPieters	Added reference
103229	view	08:48, 18 February 2019	BrittPieters	Added reference
103228	view	08:40, 18 February 2019	BrittPieters	Ontology Term : 'lysine degradation pathway' added !
103226	view	08:38, 18 February 2019	BrittPieters	Ontology Term : 'organic acidemia' added !
103221	view	08:31, 18 February 2019	BrittPieters	Modified description
103220	view	08:30, 18 February 2019	BrittPieters	Added comments Denise
103214	view	14:33, 17 February 2019	DeSl	Changed arrows for diseases to graphical interactions, some layout changes.
103181	view	15:02, 15 February 2019	BrittPieters	Modified description
103174	view	14:47, 15 February 2019	EviSchoenmaker	Arrow, boxes and overal layout changes
103159	view	13:59, 15 February 2019	BrittPieters	Added references
103149	view	11:49, 15 February 2019	BrittPieters	Added references
103145	view	09:38, 15 February 2019	BrittPieters	Added interactions
103142	view	09:14, 15 February 2019	BrittPieters	Added Rehia id's
103132	view	14:53, 14 February 2019	BrittPieters	Modified description
103124	view	17:50, 13 February 2019	DeSl	Modified title
103112	view	13:19, 13 February 2019	BrittPieters	Addition of references
103111	view	13:09, 13 February 2019	BrittPieters	Ontology Term : 'D-2-hydroxyglutaric aciduria' added !
103110	view	13:08, 13 February 2019	BrittPieters	Ontology Term : '2-hydroxyglutaric aciduria' added !
103109	view	13:08, 13 February 2019	BrittPieters	Ontology Term : 'glutaric aciduria type I pathway' added !
103108	view	13:07, 13 February 2019	BrittPieters	Ontology Term : 'Canavan disease' added !
103107	view	13:06, 13 February 2019	BrittPieters	Modified description
103105	view	13:01, 13 February 2019	BrittPieters	Modified title
103104	view	13:01, 13 February 2019	BrittPieters	Modified description
103103	view	12:56, 13 February 2019	BrittPieters	New pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/e/ec/WP4519_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/e/ec/WP4519_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106202)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}

Cerebral Organic Acidurias, including diseases (Homo sapiens)

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@@ Line 3: / Line 3: @@
    <Comment Source="WikiPathways-description">This pathway shows disorders related to the accumulation of organic acids in body fluids, resulting in cerebral organic acidurias. Symptoms often include mental or motor retardation, difficulties while moving and epilepsy. For all but one disorder, current treatment options have been proven ineffective. Disorders resulting from an enzyme defect are highlighted in pink. This pathway was inspired by Chapter 8 of the book of Blau (ISBN 3642403360 (978-3642403361)).</Comment>
    <BiopaxRef>e43</BiopaxRef>
-   <Graphics BoardWidth="1577.5798406477809" BoardHeight="896.3057819214607"/>
+   <Graphics BoardWidth="1577.5798406477809" BoardHeight="893.357960182693" />
    <DataNode TextLabel="hydroxylysine" GraphId="b8260" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:60175"/>
+     <Xref Database="ChEBI" ID="CHEBI:60175" />
    </DataNode>
    <DataNode TextLabel="Antiquitin" GraphId="e0325" Type="Protein">
-     <Graphics CenterX="1093.0" CenterY="278.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle"/>
+     <Graphics CenterX="1093.0" CenterY="278.0" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" />
-     <Xref Database="Ensembl" ID="ENSG00000164904"/>
+     <Xref Database="Ensembl" ID="ENSG00000164904" />
    </DataNode>
    <DataNode TextLabel="Tryptophan" GraphId="e0847" Type="Metabolite">
-     <Graphics CenterX="1431.8489038973069" CenterY="356.53228366018106" Width="90.0" Height="25.0" ZOrder="32768" FontSize="12" Valign="Middle" Color="0000ff"/>
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-     <Xref Database="ChEBI" ID="CHEBI:16828"/>
+     <Xref Database="ChEBI" ID="CHEBI:16828" />
    </DataNode>
    <DataNode TextLabel="Glutaric acid" GraphId="f1d18" Type="Metabolite">
-     <Graphics CenterX="1433.8306607396544" CenterY="392.25165622412896" Width="90.0" Height="25.0" ZOrder="32823" FontSize="12" Valign="Middle" Color="0000ff"/>
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-     <Xref Database="ChEBI" ID="CHEBI:17859"/>
+     <Xref Database="ChEBI" ID="CHEBI:17859" />
    </DataNode>
-   <DataNode TextLabel="Glutaconyl &#10;coenzyme A" GraphId="fc378" Type="Metabolite">
+   <DataNode TextLabel="Glutaconyl &#xA;coenzyme A" GraphId="fc378" Type="Metabolite">
-     <Graphics CenterX="1232.8304014178784" CenterY="563.7788096771629" Width="94.31489591080752" Height="31.335194547361688" ZOrder="32824" FontSize="12" Valign="Middle" Color="0000ff"/>
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-     <Xref Database="PubChem-compound" ID="9543050"/>
+     <Xref Database="PubChem-compound" ID="9543050" />
    </DataNode>
    <DataNode TextLabel="3-Hydroxyglutaric acid" GraphId="dd953" Type="Metabolite">
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-     <Xref Database="HMDB" ID="HMDB00428"/>
+     <Xref Database="HMDB" ID="HMDB0000428" />
    </DataNode>
    <DataNode TextLabel="FAD" GraphId="ad576" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:16238"/>
+     <Xref Database="ChEBI" ID="CHEBI:16238" />
    </DataNode>
    <DataNode TextLabel="TCA cycle" GraphId="b971a" Type="Pathway">
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-     <Xref Database="WikiPathways" ID="WP78"/>
+     <Xref Database="WikiPathways" ID="WP78" />
    </DataNode>
    <DataNode TextLabel="NADPH" GraphId="af50c" Type="Metabolite" GroupRef="ceb1c">
-     <Graphics CenterX="342.5999999999999" CenterY="451.66666666666674" Width="60.0" Height="25.0" ZOrder="32829" FontSize="12" Valign="Middle" Color="0000ff"/>
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-     <Xref Database="ChEBI" ID="CHEBI:16474"/>
+     <Xref Database="ChEBI" ID="CHEBI:16474" />
    </DataNode>
    <DataNode TextLabel="IDH2" GraphId="b80b7" Type="Protein">
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-     <Xref Database="Ensembl" ID="ENSG00000182054"/>
+     <Xref Database="Ensembl" ID="ENSG00000182054" />
    </DataNode>
    <DataNode TextLabel="D-2-hydroxyglutarate dehydrogenase" GraphId="ed416" Type="Protein">
-     <Graphics CenterX="687.3153787499987" CenterY="581.5256312500014" Width="204.0" Height="25.0" ZOrder="32831" FontSize="12" Valign="Middle"/>
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-     <Xref Database="Uniprot-TrEMBL" ID="B5MCV2"/>
+     <Xref Database="Uniprot-TrEMBL" ID="B5MCV2" />
    </DataNode>
    <DataNode TextLabel="Acetyl coenzyme A" GraphId="c30f3" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:15351"/>
+     <Xref Database="ChEBI" ID="CHEBI:15351" />
    </DataNode>
    <DataNode TextLabel="glutaryl-coenzyme A" GraphId="f73bd" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:15524"/>
+     <Xref Database="ChEBI" ID="CHEBI:15524" />
    </DataNode>
    <DataNode TextLabel="L-2-Aminoadipic acid" GraphId="b5625" Type="Metabolite">
-     <Graphics CenterX="1232.8304014178784" CenterY="311.603115335318" Width="124.89518961572725" Height="25.0" ZOrder="32834" FontSize="12" Valign="Middle" Color="0000ff"/>
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-     <Xref Database="ChEBI" ID="CHEBI:37024"/>
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    </DataNode>
    <DataNode TextLabel="FADH2" GraphId="f1214" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:17877"/>
+     <Xref Database="ChEBI" ID="CHEBI:17877" />
    </DataNode>
    <DataNode TextLabel="Glutaconic acid" GraphId="c052c" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:24309"/>
+     <Xref Database="ChEBI" ID="CHEBI:24309" />
    </DataNode>
    <DataNode TextLabel="NADPH+" GraphId="f41e0" Type="Metabolite">
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-     <Xref Database="HMDB" ID="HMDB00221"/>
+     <Xref Database="HMDB" ID="HMDB0000221" />
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    <DataNode TextLabel="L-2-Hydroxyglutaric acid" GraphId="acf8f" Type="Metabolite">
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-     <Xref Database="HMDB" ID="HMDB00694"/>
+     <Xref Database="HMDB" ID="HMDB0000694" />
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    <DataNode TextLabel="NADH" GraphId="b9634" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:16908"/>
+     <Xref Database="ChEBI" ID="CHEBI:16908" />
    </DataNode>
    <DataNode TextLabel="2-Oxoadipic acid" GraphId="ec409" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:15753"/>
+     <Xref Database="ChEBI" ID="CHEBI:15753" />
    </DataNode>
    <DataNode TextLabel="L2HGDH" GraphId="d4841" Type="Protein">
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-     <Xref Database="Ensembl" ID="ENSG00000087299"/>
+     <Xref Database="Ensembl" ID="ENSG00000087299" />
    </DataNode>
    <DataNode TextLabel="L-N-Acetylaspartate" GraphId="a90f9" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:21547"/>
+     <Xref Database="ChEBI" ID="CHEBI:21547" />
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    <DataNode TextLabel="H+" GraphId="a7412" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:15378"/>
+     <Xref Database="ChEBI" ID="CHEBI:15378" />
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    <DataNode TextLabel="L-malDH" GraphId="af719" Type="Protein">
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-     <Xref Database="Uniprot-TrEMBL" ID="A0A024R4K3"/>
+     <Xref Database="Uniprot-TrEMBL" ID="A0A024R4K3" />
    </DataNode>
    <DataNode TextLabel="Saccharopine pathway" GraphId="f4dce" Type="Pathway">
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-     <Xref Database="WikiPathways" ID="WP4228"/>
+     <Xref Database="WikiPathways" ID="WP4228" />
    </DataNode>
-   <DataNode TextLabel="Hydroxyacid-oxoacid &#10;transhydrogenase" GraphId="b71e0" Type="Protein">
+   <DataNode TextLabel="Hydroxyacid-oxoacid &#xA;transhydrogenase" GraphId="b71e0" Type="Protein">
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-     <Xref Database="Uniprot-TrEMBL" ID="B4DFI7"/>
+     <Xref Database="Uniprot-TrEMBL" ID="B4DFI7" />
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    <DataNode TextLabel="Aspartate" GraphId="e9a82" Type="Metabolite">
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-     <Xref Database="ChEBI" ID="CHEBI:17053"/>
+     <Xref Database="ChEBI" ID="CHEBI:17053" />
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    <DataNode TextLabel="Glutaryl-Coenzyme A dehydrogenase" GraphId="ffe83" Type="Protein">
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-      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0060159</bp:ID>
-      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
-    </bp:openControlledVocabulary>
      <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e43">
-       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
+       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
        <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
        <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> ''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases'''</bp:TITLE>
-       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
+       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
        <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
-       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
+       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
        <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
        <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
        <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(ISBN 978-3-642-40337-8)</bp:SOURCE>
        <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
-       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
+       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
        <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
        <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
        <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-642-40337-8</bp:SOURCE>
        <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
-       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
+       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
        <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
        <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
@@ Line 646: / Line 647: @@
        <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dionisi-Vici</bp:AUTHORS>
        <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carlo</bp:AUTHORS>
-    </bp:PublicationXref>
-    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ac8">
-      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19524112</bp:ID>
-      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells.</bp:TITLE>
-      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Neurochem Int</bp:SOURCE>
-      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arun P</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moffett JR</bp:AUTHORS>
-      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Namboodiri AM</bp:AUTHORS>
      </bp:PublicationXref>
      <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c79">
@@ Line 687: / Line 678: @@
        <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Salomons GS</bp:AUTHORS>
      </bp:PublicationXref>
-    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D-2-hydroxyglutaric aciduria</bp:TERM>
-      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0050575</bp:ID>
-      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
-    </bp:openControlledVocabulary>
      <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b39">
        <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7564239</bp:ID>
@@ Line 709: / Line 695: @@
        <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Superti-Furga A</bp:AUTHORS>
      </bp:PublicationXref>
-     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c4d">
+     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eca">
-       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14239091</bp:ID>
+       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6774165</bp:ID>
        <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SPONGY DEGENERATION OF THE CENTRAL NERVOUS SYSTEM IN INFANCY.</bp:TITLE>
+       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D-2-hydroxyglutaric aciduria: case report and biochemical studies.</bp:TITLE>
-       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Neurology</bp:SOURCE>
+      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Inherit Metab Dis</bp:SOURCE>
-       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1964</bp:YEAR>
+      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1980</bp:YEAR>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BANKER BQ</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chalmers RA</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ROBERTSON JT</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lawson AM</bp:AUTHORS>
-       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">VICTOR M</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watts RW</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tavill AS</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kamerling JP</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hey E</bp:AUTHORS>
+      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ogilvie D</bp:AUTHORS>
+    </bp:PublicationXref>
+    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d04">
+      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16005139</bp:ID>
+      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase.</bp:TITLE>
+       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
+       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rzem R</bp:AUTHORS>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Schaftingen E</bp:AUTHORS>
+       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Veiga-da-Cunha M</bp:AUTHORS>
      </bp:PublicationXref>
      <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
@@ Line 725: / Line 725: @@
      </bp:openControlledVocabulary>
      <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Canavan disease</bp:TERM>
+       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glutaric aciduria type I pathway</bp:TERM>
-       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:3613</bp:ID>
+       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002306</bp:ID>
-       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
+       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
      </bp:openControlledVocabulary>
    </Biopax>
 </Pathway>