Cerebral Organic Acidurias, including diseases (Homo sapiens)

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   <Comment Source="WikiPathways-description">This pathway shows disorders related to the accumulation of organic acids in body fluids, resulting in cerebral organic acidurias. Symptoms often include mental or motor retardation, difficulties while moving and epilepsy. For all but one disorder, current treatment options have been proven ineffective. Disorders resulting from an enzyme defect are highlighted in pink. This pathway was inspired by Chapter 8 of the book of Blau (ISBN 3642403360 (978-3642403361)).</Comment>
   <Comment Source="WikiPathways-description">This pathway shows disorders related to the accumulation of organic acids in body fluids, resulting in cerebral organic acidurias. Symptoms often include mental or motor retardation, difficulties while moving and epilepsy. For all but one disorder, current treatment options have been proven ineffective. Disorders resulting from an enzyme defect are highlighted in pink. This pathway was inspired by Chapter 8 of the book of Blau (ISBN 3642403360 (978-3642403361)).</Comment>
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       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1964</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hedlund GL</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BANKER BQ</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Longo N</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ROBERTSON JT</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pasquali M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">VICTOR M</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glutaric aciduria type I pathway</bp:TERM>
+
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-hydroxyglutaric aciduria</bp:TERM>
-
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002306</bp:ID>
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       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0050573</bp:ID>
-
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
+
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a07">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a07">
Line 582: Line 592:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stokke O</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Stokke O</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jellum E</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jellum E</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ac8">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19524112</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells.</bp:TITLE>
 +
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Neurochem Int</bp:SOURCE>
 +
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arun P</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moffett JR</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Namboodiri AM</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2-hydroxyglutaric aciduria</bp:TERM>
+
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D-2-hydroxyglutaric aciduria</bp:TERM>
-
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0050573</bp:ID>
+
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0050575</bp:ID>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eca">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="dc4">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6774165</bp:ID>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16602100</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D-2-hydroxyglutaric aciduria: case report and biochemical studies.</bp:TITLE>
+
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Glutaric acidemia type 1.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Inherit Metab Dis</bp:SOURCE>
+
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Am J Med Genet C Semin Med Genet</bp:SOURCE>
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1980</bp:YEAR>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chalmers RA</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lawson AM</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watts RW</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tavill AS</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kamerling JP</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hey E</bp:AUTHORS>
+
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ogilvie D</bp:AUTHORS>
+
-
    </bp:PublicationXref>
+
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d04">
+
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16005139</bp:ID>
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-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
+
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase.</bp:TITLE>
+
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
+
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rzem R</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hedlund GL</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Schaftingen E</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Longo N</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Veiga-da-Cunha M</bp:AUTHORS>
+
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pasquali M</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">organic acidemia</bp:TERM>
 
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0060159</bp:ID>
 
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
 
-
    </bp:openControlledVocabulary>
 
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e43">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="e43">
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> ''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases'''</bp:TITLE>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"> ''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases'''</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
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       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:SOURCE>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(ISBN 978-3-642-40337-8)</bp:SOURCE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">(ISBN 978-3-642-40337-8)</bp:SOURCE>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-642-40337-8</bp:SOURCE>
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-642-40337-8</bp:SOURCE>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"/>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string"></bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">''Physician's Guidee to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases''</bp:TITLE>
Line 646: Line 647:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dionisi-Vici</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Dionisi-Vici</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carlo</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Carlo</bp:AUTHORS>
-
    </bp:PublicationXref>
 
-
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ac8">
 
-
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19524112</bp:ID>
 
-
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 
-
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells.</bp:TITLE>
 
-
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Neurochem Int</bp:SOURCE>
 
-
      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Arun P</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Moffett JR</bp:AUTHORS>
 
-
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Namboodiri AM</bp:AUTHORS>
 
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c79">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c79">
Line 687: Line 678:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Salomons GS</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Salomons GS</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
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    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D-2-hydroxyglutaric aciduria</bp:TERM>
 
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0050575</bp:ID>
 
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
 
-
    </bp:openControlledVocabulary>
 
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b39">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b39">
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7564239</bp:ID>
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">7564239</bp:ID>
Line 709: Line 695:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Superti-Furga A</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Superti-Furga A</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c4d">
+
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="eca">
-
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">14239091</bp:ID>
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       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">6774165</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
-
       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">SPONGY DEGENERATION OF THE CENTRAL NERVOUS SYSTEM IN INFANCY.</bp:TITLE>
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       <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">D-2-hydroxyglutaric aciduria: case report and biochemical studies.</bp:TITLE>
-
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Neurology</bp:SOURCE>
+
      <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">J Inherit Metab Dis</bp:SOURCE>
-
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1964</bp:YEAR>
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      <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">1980</bp:YEAR>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">BANKER BQ</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Chalmers RA</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ROBERTSON JT</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lawson AM</bp:AUTHORS>
-
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">VICTOR M</bp:AUTHORS>
+
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watts RW</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tavill AS</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kamerling JP</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hey E</bp:AUTHORS>
 +
      <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ogilvie D</bp:AUTHORS>
 +
    </bp:PublicationXref>
 +
    <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d04">
 +
      <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">16005139</bp:ID>
 +
      <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
 +
      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase.</bp:TITLE>
 +
       <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biochimie</bp:SOURCE>
 +
       <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2006</bp:YEAR>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rzem R</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Van Schaftingen E</bp:AUTHORS>
 +
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Veiga-da-Cunha M</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
Line 725: Line 725:
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Canavan disease</bp:TERM>
+
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">glutaric aciduria type I pathway</bp:TERM>
-
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:3613</bp:ID>
+
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002306</bp:ID>
-
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
+
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
106202view12:09, 16 August 2019MaintBotHMDB identifier normalization
104246view18:45, 11 May 2019EgonwRemoved a copy/paste error.
104245view18:44, 11 May 2019EgonwRemoved the RHEA: prefix from the identifier.
104031view17:43, 25 April 2019IreneHemelModified description
103578view10:17, 18 March 2019EviSchoenmakerLayout adjustment
103563view09:55, 15 March 2019BrittPietersChanged gene product to proteins
103391view19:08, 25 February 2019DeSlUpdated ID for N-acetylaspartate (was annotated with protein ID, not metabolite ID).
103389view15:33, 25 February 2019DeSlRemoved weird signs in lit. ref
103317view09:15, 22 February 2019BrittPietersTest for CHEBI adaptations
103253view15:27, 18 February 2019BrittPietersAdded Antiquitin
103246view10:27, 18 February 2019BrittPietersChanges in Rhea ID
103241view09:49, 18 February 2019BrittPietersChange Rhea ID
103231view08:53, 18 February 2019BrittPietersAdded reference
103229view08:48, 18 February 2019BrittPietersAdded reference
103228view08:40, 18 February 2019BrittPietersOntology Term : 'lysine degradation pathway' added !
103226view08:38, 18 February 2019BrittPietersOntology Term : 'organic acidemia' added !
103221view08:31, 18 February 2019BrittPietersModified description
103220view08:30, 18 February 2019BrittPietersAdded comments Denise
103214view14:33, 17 February 2019DeSlChanged arrows for diseases to graphical interactions, some layout changes.
103181view15:02, 15 February 2019BrittPietersModified description
103174view14:47, 15 February 2019EviSchoenmakerArrow, boxes and overal layout changes
103159view13:59, 15 February 2019BrittPietersAdded references
103149view11:49, 15 February 2019BrittPietersAdded references
103145view09:38, 15 February 2019BrittPietersAdded interactions
103142view09:14, 15 February 2019BrittPietersAdded Rehia id's
103132view14:53, 14 February 2019BrittPietersModified description
103124view17:50, 13 February 2019DeSlModified title
103112view13:19, 13 February 2019BrittPietersAddition of references
103111view13:09, 13 February 2019BrittPietersOntology Term : 'D-2-hydroxyglutaric aciduria' added !
103110view13:08, 13 February 2019BrittPietersOntology Term : '2-hydroxyglutaric aciduria' added !
103109view13:08, 13 February 2019BrittPietersOntology Term : 'glutaric aciduria type I pathway' added !
103108view13:07, 13 February 2019BrittPietersOntology Term : 'Canavan disease' added !
103107view13:06, 13 February 2019BrittPietersModified description
103105view13:01, 13 February 2019BrittPietersModified title
103104view13:01, 13 February 2019BrittPietersModified description
103103view12:56, 13 February 2019BrittPietersNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/e/ec/WP4519_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/e/ec/WP4519_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106202)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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