DNA Replication (Danio rerio)

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1, 2Orc ComplexCdt1Mcm4Cdc6Orc5p180RFC36Orc5Mcm3Orc2RFC Heteropentamer:RNA primer-DNA primer:RNA primer-DNA primerMcm6p49Degraded by proteasome in cytosolDegraded by proteasome in cytosolCdt1Phosphorylated Cdc6RNA primer-DNA primerPre-replicative complexATPp70ATPMcm10Mcm5Cdt1CTP2. Activation of the pre-replicative complexOrc1dCTPOrc complexCdt1Pre-replicative complexRNA Primer1. Assembly of the pre-replicative complexPCNA homotrimerDNA polymerase alpha: primase: origin complexDNA polymerase alpha: primase: origin complexMcm6RFC Heteropentamer:RNA primer-DNA primerADPMcm5Orc complexRFC140RFC37Orc2RFC38ATPOrc3dGTPOrc3p58DNA PolymeraseMcm2Orc35. Leading/lagging strand synthesisRNA primer-DNA primer:origin duplex:PCNAOrc complexATPGTPCdc6Mcm4UbiquitinMcm 4,6,7 trimer forms and associatesOrc2Mcm73. DNA replication initiationOrc4PrimaseOrc complexPhosphorylated Orc1Processive complexUbiquitinPhosphorylation of Mcm 2-7 complexOrigin4. Switching of origins to post-replicative stateUbiquitinated Orc1UTPdATPOrc5Cdc6Orc4Cdc6GemininMcm7Cdt1Orc2Orc3RFC40Ubiquitinated Cdc6Mcm2dUTPaMcm3with the replication forkADPzgc:77841pold2UBCPOLD1POLEzgc:110810mcm2orc3lzgc:56264rpa2MCM10POLE2POLD3RPA4ASKorc1POLD4zgc:110727prim1gmnnzgc:56310CDC6pcnarpa1zgc:85772zgc:101602mcm4rfc4ORC2MCM6mcm5rfc5POLA1RFC1orc6mcm3UBA52zgc:77827rfc3CDT1zgc:56598MCM7POLA2


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


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GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


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91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


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NameTypeDatabase referenceComment
CDC6GeneProductENSDARG00000009942 (Ensembl)
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2GeneProductENSDARG00000101465 (Ensembl)
POLA1GeneProductENSDARG00000045308 (Ensembl)
POLA2GeneProductENSDARG00000015070 (Ensembl)
POLD1GeneProduct556456 (Entrez Gene)
POLD3GeneProductENSDARG00000076169 (Ensembl)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RFC1GeneProductENSDARG00000054799 (Ensembl)
UBA52GeneProduct641289 (Entrez Gene)
UBCGeneProductENSDARG00000102632 (Ensembl)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1GeneProductENSDARG00000039217 (Ensembl)
orc3lGeneProduct334315 (Entrez Gene)
orc6GeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProductENSDARG00000095046 (Ensembl)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

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