DNA Replication (Danio rerio)

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1, 2Orc2Orc complex1. Assembly of the pre-replicative complexMcm6Cdc6PrimaseRFC Heteropentamer:RNA primer-DNA primer:Degraded by proteasome in cytosolRNA primer-DNA primerRNA primer-DNA primer:origin duplex:PCNAMcm6GemininADPProcessive complexPhosphorylation of Mcm 2-7 complexCdt1Pre-replicative complexMcm3Mcm 4,6,7 trimer forms and associatesCdt1Mcm2PCNA homotrimerOrc2Orc2GTPp58DNA PolymerasedATPRFC36Orc complexCTPMcm3Orc3Orc53. DNA replication initiationUbiquitinated Cdc6Mcm4Cdc6Degraded by proteasome in cytosolUbiquitinated Orc1aCdt1RFC140RNA PrimerOrc3Cdt1Mcm10Mcm5Orc5Orc complexMcm7Mcm2DNA polymerase alpha: primase: origin complexPre-replicative complexOrc52. Activation of the pre-replicative complexdUTPdCTPMcm4p70Cdc6Phosphorylated Orc1Orc1p180RFC Heteropentamer:RNA primer-DNA primerOriginADPMcm7RFC37UbiquitinMcm5Orc4RNA primer-DNA primerATPOrc ComplexPhosphorylated Cdc6Cdt1ATP4. Switching of origins to post-replicative stateOrc3dGTPRFC385. Leading/lagging strand synthesisATPCdc6Ubiquitinwith the replication forkOrc complexOrc2Orc4UTPp49RFC40Orc3DNA polymerase alpha: primase: origin complexATPorc6lrfc5MCM6mcm4mcm5mcm3POLD4orc3lUBA52zgc:110810orc1lrpa1pcnazgc:110727zgc:101602ORC2Lzgc:56264rpa2zgc:85772zgc:56310mcm2rfc4POLE2zgc:77841RPA4ASKgmnnpold2POLD1MCM10CDT1RFC1POLEPOLD3CDC6rfc3zgc:56598POLAMCM7UBCzgc:77827prim1


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


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GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


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91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


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NameTypeDatabase referenceComment
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
POLD1GeneProduct556456 (Entrez Gene)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
UBA52GeneProduct641289 (Entrez Gene)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

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