DNA Replication (Danio rerio)

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1, 2Orc55. Leading/lagging strand synthesisPre-replicative complexMcm4Orc ComplexRNA primer-DNA primer:origin duplex:PCNAPCNA homotrimerUbiquitinated Cdc6Degraded by proteasome in cytosolRFC Heteropentamer:RNA primer-DNA primer:Mcm4Cdt1ATPOrc complexCdt1Cdc6aMcm2RFC140Mcm10Cdt1ATPOrc3with the replication forkCTPp49PrimasedUTPp180Processive complexDNA polymerase alpha: primase: origin complexMcm2OriginOrc22. Activation of the pre-replicative complexUbiquitinated Orc1Mcm3Cdc6Degraded by proteasome in cytosolPhosphorylated Cdc6DNA PolymeraseCdt1RFC40ATPOrc2HOMOLOGY MAPPCdc6Cdt1Mcm5Orc3Orc complexMcm61. Assembly of the pre-replicative complexDNA polymerase alpha: primase: origin complex3. DNA replication initiationOrc3Pre-replicative complexdGTPRNA PrimerMcm3p58Orc2dATPOrc4p70Orc3Mcm5ATPMcm6RFC36Mcm 4,6,7 trimer forms and associatesOrc complexOrc5RNA primer-DNA primerUTPMcm7ADPCdc6RNA primer-DNA primerMcm7Orc1dCTPRFC374. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primerGemininPhosphorylated Orc1UbiquitinOrc complexOrc4Orc5GTPADPRFC38Orc2Phosphorylation of Mcm 2-7 complexUbiquitinorc1lzgc:77841UBA52mcm5MCM6mcm4POLD3POLECDT1rfc3zgc:85772zgc:101602RFC1prim1ASKorc3lrpa1zgc:77827mcm3rfc5zgc:110727zgc:56598zgc:56310pcnaorc6lzgc:56264POLD4MCM7gmnnzgc:110810POLE2pold2POLD1rfc4MCM10RPA4mcm2CDC6UBCORC2Lrpa2POLA


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


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GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


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91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


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NameTypeDatabase referenceComment
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
POLD1GeneProduct556456 (Entrez Gene)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
UBA52GeneProduct641289 (Entrez Gene)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

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