DNA Replication (Danio rerio)

From WikiPathways

Revision as of 05:32, 6 July 2013 by MaintBot (Talk | contribs)
Jump to: navigation, search
1, 2Orc24. Switching of origins to post-replicative state3. DNA replication initiationMcm3Mcm7RFC Heteropentamer:RNA primer-DNA primer:ATPUbiquitinated Orc1Degraded by proteasome in cytosolPCNA homotrimerMcm3Cdt1Ubiquitin5. Leading/lagging strand synthesisMcm10GemininDNA PolymeraseCdt1RFC40Cdt1Cdc6RFC Heteropentamer:RNA primer-DNA primerOriginUbiquitinDNA polymerase alpha: primase: origin complexADPRNA primer-DNA primer:origin duplex:PCNAdGTPp70Orc complexDNA polymerase alpha: primase: origin complex1. Assembly of the pre-replicative complexOrc3HOMOLOGY MAPPPre-replicative complexPhosphorylated Cdc6Mcm2Orc2Ubiquitinated Cdc6ADPPrimaseCdc6RFC38UTPwith the replication forkMcm5Orc ComplexCdc6Orc complexOrc1Orc complexMcm4Pre-replicative complexPhosphorylation of Mcm 2-7 complex2. Activation of the pre-replicative complexOrc2adCTPATPMcm2p49Orc4dUTPOrc5p58Orc2Mcm5RNA primer-DNA primerMcm4p180RFC140Orc complexOrc3Degraded by proteasome in cytosolGTPMcm6ATPCdc6RNA primer-DNA primerMcm6Orc4RNA PrimerRFC36Mcm7Orc3Cdt1dATPMcm 4,6,7 trimer forms and associatesProcessive complexOrc5Orc3CTPATPRFC37Orc5Cdt1Phosphorylated Orc1zgc:85772zgc:56598CDT1MCM6UBA52mcm5pold2POLE2gmnnrfc4zgc:77827ASKzgc:110810POLApcnaPOLEzgc:101602UBCORC2Lmcm4zgc:77841prim1MCM10RFC1orc1lrpa1POLD3mcm2orc6lrfc3zgc:110727zgc:56264rpa2POLD4rfc5MCM7zgc:56310mcm3POLD1CDC6orc3lRPA4


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


GenMAPP notes 
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


View all...
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


View all...
NameTypeDatabase referenceComment
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
POLD1GeneProduct556456 (Entrez Gene)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
UBA52GeneProduct641289 (Entrez Gene)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools