DNA Replication (Danio rerio)

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1, 2ADPdATPMcm5Orc4Orc3Mcm7UTPwith the replication forkCdt1Ubiquitinated Orc1Phosphorylated Cdc6Orc3Mcm6Pre-replicative complexOrc3Orc complex4. Switching of origins to post-replicative stateOrc complexdUTPUbiquitinp49Orc2HOMOLOGY MAPPp70RNA primer-DNA primer:origin duplex:PCNARFC36Cdt1Mcm7RFC37ATPRNA PrimerRFC38RNA primer-DNA primerATPRFC Heteropentamer:RNA primer-DNA primerOrc3GTPCdc6aOrc55. Leading/lagging strand synthesis1. Assembly of the pre-replicative complexp58PCNA homotrimerRFC40Mcm2Ubiquitinated Cdc6GemininATPMcm32. Activation of the pre-replicative complexOrc2Pre-replicative complexCdc6Cdt1DNA polymerase alpha: primase: origin complexRFC140Phosphorylation of Mcm 2-7 complexMcm5DNA PolymeraseDegraded by proteasome in cytosolCdc6Phosphorylated Orc1OriginUbiquitinOrc ComplexOrc complexDNA polymerase alpha: primase: origin complexMcm4PrimaseOrc5Mcm 4,6,7 trimer forms and associatesDegraded by proteasome in cytosolRNA primer-DNA primerMcm2Cdc6Orc2Orc4Cdt1Cdt1ATPdGTPMcm4RFC Heteropentamer:RNA primer-DNA primer:Orc complexCTPMcm6Orc5Orc2p180Processive complexOrc1Mcm10dCTP3. DNA replication initiationADPMcm3CDC6POLD1CDT1POLD4zgc:110727POLEzgc:77827zgc:56310MCM6ORC2Lorc6lzgc:85772pcnarfc4gmnnorc1lzgc:56264MCM7zgc:101602POLAmcm2POLE2orc3lUBCrpa1RPA4rfc5mcm3zgc:77841zgc:110810rpa2RFC1prim1ASKzgc:56598rfc3mcm4mcm5pold2POLD3MCM10UBA52


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


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GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


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91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


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NameTypeDatabase referenceComment
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
POLD1GeneProduct556456 (Entrez Gene)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
UBA52GeneProduct641289 (Entrez Gene)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

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