DNA Replication (Danio rerio)

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1, 2ATPdUTPMcm5Orc5Orc2Mcm6GTPUbiquitinCdc6Phosphorylated Cdc6ADPOriginMcm43. DNA replication initiationOrc2Processive complexMcm75. Leading/lagging strand synthesisdGTPMcm 4,6,7 trimer forms and associatesADPOrc5Mcm5p58RFC Heteropentamer:RNA primer-DNA primer:p180Mcm10Mcm6RFC36RFC Heteropentamer:RNA primer-DNA primerATPRFC37RNA primer-DNA primerUTPOrc3Orc1CTPGemininDNA PolymeraseOrc34. Switching of origins to post-replicative statePre-replicative complexp49ATPRFC381. Assembly of the pre-replicative complexUbiquitinated Orc1Cdt1RNA primer-DNA primerHOMOLOGY MAPPMcm2Pre-replicative complexwith the replication forkaOrc2Cdc6DNA polymerase alpha: primase: origin complexRFC40Cdt1Orc complexPrimaseUbiquitinated Cdc6Orc ComplexdATPPhosphorylated Orc1Mcm7Orc complexPhosphorylation of Mcm 2-7 complexMcm3RNA primer-DNA primer:origin duplex:PCNAOrc2RFC140Degraded by proteasome in cytosolDegraded by proteasome in cytosolCdt1Cdc6Orc3Orc5Cdc6Cdt1UbiquitindCTPMcm3PCNA homotrimerOrc complexDNA polymerase alpha: primase: origin complexMcm4Orc3Orc4p70Orc complexOrc4Cdt1RNA Primer2. Activation of the pre-replicative complexATPMcm2POLD1POLD4gmnnPOLD3prim1POLE2ORC2LUBA52orc3lorc1lzgc:77827RFC1rfc5orc6lzgc:85772rpa1mcm2ASKRPA4mcm3zgc:110727POLECDC6zgc:101602zgc:56310zgc:77841mcm4zgc:56598rpa2rfc3UBCzgc:110810POLApcnaMCM10rfc4mcm5MCM6zgc:56264pold2MCM7CDT1


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


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GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


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91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


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NameTypeDatabase referenceComment
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
POLD1GeneProduct556456 (Entrez Gene)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
UBA52GeneProduct641289 (Entrez Gene)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

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