DNA Replication (Danio rerio)

From WikiPathways

Revision as of 15:49, 11 February 2010 by Thomas (Talk | contribs)
Jump to: navigation, search
1, 2Ubiquitinated Orc1UbiquitinCdc6ATP5. Leading/lagging strand synthesisRNA PrimerOrc3Mcm3Degraded by proteasome in cytosolUbiquitinated Cdc6Orc5Orc ComplexMcm2Orc4Orc complexOrc complexOrc complexPhosphorylated Orc1Orc2p70Orc5RFC36OriginDNA PolymeraseRFC38DNA polymerase alpha: primase: origin complexCdc6RFC40RFC Heteropentamer:RNA primer-DNA primer:dGTPRFC140ADPdCTPPCNA homotrimerOrc4ATPMcm10Orc32. Activation of the pre-replicative complexOrc1Processive complexMcm3p180RNA primer-DNA primer:origin duplex:PCNAMcm 4,6,7 trimer forms and associatesMcm4Degraded by proteasome in cytosolCdt1p49Mcm6Pre-replicative complexRFC Heteropentamer:RNA primer-DNA primer3. DNA replication initiationCdt1GemininGTPUbiquitinDNA polymerase alpha: primase: origin complexHOMOLOGY MAPPPre-replicative complexRNA primer-DNA primerMcm2ATPOrc2ADPCdt1Mcm5CTPMcm7aOrc3with the replication forkRNA primer-DNA primerATPMcm4Cdt1Orc2Orc3Cdt1Cdc6Phosphorylated Cdc6dATPMcm7PrimaseMcm5UTP4. Switching of origins to post-replicative stateOrc2Cdc6RFC37Orc complexOrc5Phosphorylation of Mcm 2-7 complexdUTP1. Assembly of the pre-replicative complexp58Mcm6UBCMCM6CDC6POLEORC2Lorc1lPOLAmcm4zgc:85772CDT1orc6lzgc:101602zgc:110810UBA52gmnnPOLD3zgc:56598zgc:56264zgc:110727MCM10orc3lzgc:77827zgc:56310pold2prim1rfc3RPA4MCM7rfc4pcnaASKPOLE2rpa1rfc5RFC1mcm2rpa2mcm3POLD4POLD1zgc:77841mcm5


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


GenMAPP notes 
GenMAPP remarks 
Based on www.genomeknowledge.org

Quality Tags

Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


View all...
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


View all...
NameTypeDatabase referenceComment
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
POLD1GeneProduct556456 (Entrez Gene)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
UBA52GeneProduct641289 (Entrez Gene)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools