DNA Replication (Danio rerio)

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Mcm2Cdt1Degraded by proteasome in cytosolMcm7Mcm 4,6,7 trimer forms and associatesGemininUbiquitinPre-replicative complexOrc2Mcm4Mcm3ADPOrc2p180ADPPhosphorylation of Mcm 2-7 complexATPPhosphorylated Orc1Mcm6Orc5RNA PrimerOrc complexp70Mcm5DNA polymerase alpha: primase: origin complexRNA primer-DNA primerHOMOLOGY MAPPdUTPPrimaseCdc6Cdc6Cdt1Mcm2Orc3Orc complex1. Assembly of the pre-replicative complexGTPRFC40Cdt13. DNA replication initiationPCNA homotrimerRNA primer-DNA primerOrc3RFC36Mcm10Orc complexMcm6ATPOrc1Processive complexOrc2Ubiquitinated Cdc6with the replication forkOrc3Pre-replicative complexUbiquitinated Orc1Orc4ATPPhosphorylated Cdc6DNA PolymeraseCdc6Mcm7Orc ComplexATPCdc6Orc4ap58Orc5CTPUTPOrigin4. Switching of origins to post-replicative state5. Leading/lagging strand synthesisOrc2p49RFC37RFC Heteropentamer:RNA primer-DNA primer:RFC Heteropentamer:RNA primer-DNA primerdATPCdt1Degraded by proteasome in cytosolDNA polymerase alpha: primase: origin complexOrc5Orc3Mcm42. Activation of the pre-replicative complexRFC140UbiquitindGTPMcm5RFC38RNA primer-DNA primer:origin duplex:PCNACdt1Mcm3Orc complexdCTPprim1MCM7RPA4POLE2mcm4pold2gmnnzgc:56264mcm2POLD4ASKorc3lrfc4rfc5CDC6rpa2zgc:101602zgc:77827zgc:85772zgc:110727POLEzgc:110810POLD3orc6lpcnaUBA52RFC1rpa1POLD1ORC2Lmcm5zgc:56310rfc3zgc:77841MCM10MCM6CDT1zgc:56598mcm3orc1lUBCPOLA


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia


GenMAPP notes 
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


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91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


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NameTypeDatabase referenceComment
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
POLD1GeneProduct556456 (Entrez Gene)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
UBA52GeneProduct641289 (Entrez Gene)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

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