DNA Replication (Danio rerio)

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Mcm4Orc5ATPPre-replicative complexp180Orc4RNA PrimerPrimaseMcm7Mcm6Ubiquitinated Cdc6RNA primer-DNA primerdGTPCdt1dCTPATP3. DNA replication initiationDNA polymerase alpha: primase: origin complexHOMOLOGY MAPPMcm7RNA primer-DNA primer5. Leading/lagging strand synthesisGemininADPProcessive complexGTPOrc3Orc2Orc complexOrc4Orc3aOrc complexMcm3DNA PolymeraseMcm10p58Cdt1RNA primer-DNA primer:origin duplex:PCNAUbiquitinPhosphorylated Cdc6Orc5ATPCdc64. Switching of origins to post-replicative stateOrc complexOrc ComplexMcm 4,6,7 trimer forms and associatesOrc2Mcm4Orc5Phosphorylated Orc1RFC37RFC40PCNA homotrimerdATPMcm5Orc3Phosphorylation of Mcm 2-7 complexdUTPRFC Heteropentamer:RNA primer-DNA primerOrc1Cdc61. Assembly of the pre-replicative complexUbiquitinated Orc1Mcm2Orc3ATPDegraded by proteasome in cytosolOriginCdt1Cdt1Mcm5Cdt1Mcm2RFC38Degraded by proteasome in cytosolADPwith the replication forkRFC140UTPMcm3UbiquitinCdc6Orc22. Activation of the pre-replicative complexRFC Heteropentamer:RNA primer-DNA primer:p70RFC36CTPOrc complexp49Orc2Cdc6Pre-replicative complexMcm6DNA polymerase alpha: primase: origin complexUBA52rpa2orc6lRFC1orc3lzgc:110810CDC6CDT1ASKrfc5RPA4mcm2mcm3rpa1rfc4prim1zgc:110727POLD4zgc:56310MCM10UBCpcnaPOLD1POLEzgc:77841zgc:77827zgc:56598rfc3zgc:101602POLApold2orc1lMCM7mcm4MCM6zgc:85772ORC2Lmcm5gmnnPOLE2zgc:56264POLD3


DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]


GenMAPP notes 
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms



  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia


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91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references


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NameTypeDatabase referenceComment
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
POLD1GeneProduct556456 (Entrez Gene)
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
UBA52GeneProduct641289 (Entrez Gene)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1lGeneProduct335020 (Entrez Gene)
orc3lGeneProduct334315 (Entrez Gene)
orc6lGeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProduct368733 (Entrez Gene)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

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