Vitamin D in inflammatory diseases (Homo sapiens)

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1, 2InductionT-cell receptoractivationCell stress (UV-light, heat),proinflammatory cytokinesgrowth factorsIL6 and TNF expressioninflammation, apoptosis, cell growth, cell differentiationProinflammatory cytokines,oxidative stress,UV light,Bacterial products e.g. LPSVitamin DCortisolCalcineurinDNATGFB receptoractivationNucleusMAP3K1MAP2K6RXRSMAD3p38NFkBMAP2K3SMAD4IkBAPPP3CAPPP3R1MKP1IL6TNFIkKBRELAIkKGIkKANFATVDRVDRMed14GCRVDRSMAD3NFATRELANFkBIkBARXRDNADNADNAInductionPPPPP


Description

Vitamin D in inflammatory diseases.

Inhibition of the p38 MAP kinase pathway. Proinflammatory stimuli lead to p38 MAP kinase phosphorylation and activation which subsequently induces expression of many proinflammatory proteins. MED14 is part of the mediator complex involved in the regulation of transcriptional initiation and it was found to form a complex with VDR and mediate ligand-dependent enhancement of transcription by the VDR. SMAD, NFAT and NFκB signaling and modulation of these

signaling pathways by VDR/RXR.

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Ontology Terms

 

Bibliography

  1. Wöbke TK, Sorg BL, Steinhilber D; ''Vitamin D in inflammatory diseases.''; Front Physiol, 2014 PubMed Europe PMC
  2. Lawrence T; ''The nuclear factor NF-kappaB pathwayin inflammation.''; Cold Spring Harb Perspect Biol, 2009 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107171view14:25, 17 September 2019MaintBotChEBI identifier normalization
103405view10:18, 27 February 2019LaurentAlligned genes, arrows etc.
103404view10:12, 27 February 2019LaurentUpdated gene states
103133view19:26, 14 February 2019KhanspersModified description
102528view01:28, 4 January 2019Khanspersconverted appropriate interactions to graphical lines
102270view22:23, 16 December 2018AndraOntology Term : 'infectious disease pathway' added !
102269view22:23, 16 December 2018AndraOntology Term : 'vitamin D metabolic pathway' added !
102268view22:22, 16 December 2018AndraOntology Term : 'disease by infectious agent' added !
102267view22:19, 16 December 2018Andraconnected unconnected line
102262view15:50, 15 December 2018EgonwConverted to labels to metabolite data nodes.
102257view15:40, 13 December 2018LaurentModified description
102256view15:38, 13 December 2018LaurentNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CortisolMetabolite17650 (ChEBI)
GCRGeneProduct2908 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IkBAGeneProduct4792 (Entrez Gene)
IkKAGeneProduct1147 (Entrez Gene)
IkKBGeneProduct3551 (Entrez Gene)
IkKGGeneProduct8517 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MKP1GeneProduct1843 (Entrez Gene)
Med14GeneProduct9282 (Entrez Gene)
NFATGeneProduct4772 (Entrez Gene)
NFkBGeneProduct4790 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RXRGeneProduct6256 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
VDRGeneProduct7421 (Entrez Gene)
Vitamin DMetabolite27300 (ChEBI)
p38GeneProduct1432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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