Vitamin D in inflammatory diseases (Homo sapiens)

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1, 2T-cell receptoractivationTGFB receptoractivationProinflammatory cytokines,oxidative stress,UV light,Bacterial products e.g. LPSDNACortisolCalcineurinVitamin DNucleusCell stress (UV-light, heat),proinflammatory cytokinesgrowth factorsIL6 and TNF expressioninflammation, apoptosis, cell growth, cell differentiationInductionp38TNFIL6IkKBIkBAMAP2K3IkKASMAD4PPP3R1NFkBRELARXRMAP2K6NFATSMAD3MAP3K1MKP1IkKGPPP3CAPVDRVDRMed14GCRVDRSMAD3NFATPPRELANFkBIkBAPRXRDNADNADNAInduction


Vitamin D in inflammatory diseases. Inhibition of the p38 MAP kinase pathway. Proinflammatory stimuli lead to p38MAP kinase phosphorylation and activation which subsequently induces expression of many proinflammatory proteins. MED14 is part of the mediator complex involved in the regulation of transcriptional initiation and it was found to form a complex with VDR and mediate ligand-dependent enhancement of transcription by the VDR. SMAD, NFAT and NFκB signaling and modulation of these signaling pathways by VDR/RXR.

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Ontology Terms



  1. Wöbke TK, Sorg BL, Steinhilber D; ''Vitamin D in inflammatory diseases.''; Front Physiol, 2014 PubMed Europe PMC Scholia
  2. Lawrence T; ''The nuclear factor NF-kappaB pathwayin inflammation.''; Cold Spring Harb Perspect Biol, 2009 PubMed Europe PMC Scholia


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112969view09:12, 24 October 2020DeSlUpdating ID for cortisol to avoid duplicate mappings
108315view10:26, 5 December 2019EgonwModified description
108314view10:26, 5 December 2019EgonwFixed char encoding issues and some spelling errors.
107171view14:25, 17 September 2019MaintBotChEBI identifier normalization
103405view10:18, 27 February 2019LaurentAlligned genes, arrows etc.
103404view10:12, 27 February 2019LaurentUpdated gene states
103133view19:26, 14 February 2019KhanspersModified description
102528view01:28, 4 January 2019Khanspersconverted appropriate interactions to graphical lines
102270view22:23, 16 December 2018AndraOntology Term : 'infectious disease pathway' added !
102269view22:23, 16 December 2018AndraOntology Term : 'vitamin D metabolic pathway' added !
102268view22:22, 16 December 2018AndraOntology Term : 'disease by infectious agent' added !
102267view22:19, 16 December 2018Andraconnected unconnected line
102262view15:50, 15 December 2018EgonwConverted to labels to metabolite data nodes.
102257view15:40, 13 December 2018LaurentModified description
102256view15:38, 13 December 2018LaurentNew pathway

External references


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NameTypeDatabase referenceComment
CortisolMetabolite17650 (ChEBI)
GCRGeneProduct2908 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IkBAGeneProduct4792 (Entrez Gene)
IkKAGeneProduct1147 (Entrez Gene)
IkKBGeneProduct3551 (Entrez Gene)
IkKGGeneProduct8517 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MKP1GeneProduct1843 (Entrez Gene)
Med14GeneProduct9282 (Entrez Gene)
NFATGeneProduct4772 (Entrez Gene)
NFkBGeneProduct4790 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RXRGeneProduct6256 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
VDRGeneProduct7421 (Entrez Gene)
Vitamin DMetabolite27300 (ChEBI)
p38GeneProduct1432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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