Vitamin D in inflammatory diseases (Homo sapiens)

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1, 2IL6 and TNF expressioninflammation, apoptosis, cell growth, cell differentiationCalcineurinCell stress (UV-light, heat),proinflammatory cytokinesgrowth factorsTGFB receptoractivationProinflammatory cytokines,oxidative stress,UV light,Bacterial products e.g. LPSVitamin DT-cell receptoractivationInductionNucleusDNACortisolPPP3CASMAD4NFkBIkBARXRMKP1RELAIkKAIkKBMAP2K3NFATIkKGTNFPPP3R1MAP2K6p38MAP3K1IL6SMAD3PVDRVDRMed14GCRVDRSMAD3NFATPPRELANFkBIkBARXRPDNADNADNAInduction


Vitamin D in inflammatory diseases. Inhibition of the p38 MAP kinase pathway. Proinflammatory stimuli lead to p38MAP kinase phosphorylation and activation which subsequently induces expression of many proinflammatory proteins. MED14 is part of the mediator complex involved in the regulation of transcriptional initiation and it was found to form a complex with VDR and mediate ligand-dependent enhancement of transcription by the VDR. SMAD, NFAT and NFκB signaling and modulation of these signaling pathways by VDR/RXR.

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Ontology Terms



  1. Wöbke TK, Sorg BL, Steinhilber D; ''Vitamin D in inflammatory diseases.''; Front Physiol, 2014 PubMed Europe PMC
  2. Lawrence T; ''The nuclear factor NF-kappaB pathwayin inflammation.''; Cold Spring Harb Perspect Biol, 2009 PubMed Europe PMC


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107171view14:25, 17 September 2019MaintBotChEBI identifier normalization
103405view10:18, 27 February 2019LaurentAlligned genes, arrows etc.
103404view10:12, 27 February 2019LaurentUpdated gene states
103133view19:26, 14 February 2019KhanspersModified description
102528view01:28, 4 January 2019Khanspersconverted appropriate interactions to graphical lines
102270view22:23, 16 December 2018AndraOntology Term : 'infectious disease pathway' added !
102269view22:23, 16 December 2018AndraOntology Term : 'vitamin D metabolic pathway' added !
102268view22:22, 16 December 2018AndraOntology Term : 'disease by infectious agent' added !
102267view22:19, 16 December 2018Andraconnected unconnected line
102262view15:50, 15 December 2018EgonwConverted to labels to metabolite data nodes.
102257view15:40, 13 December 2018LaurentModified description
102256view15:38, 13 December 2018LaurentNew pathway

External references


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NameTypeDatabase referenceComment
CortisolMetaboliteCHEBI:17650 (ChEBI)
GCRGeneProduct2908 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IkBAGeneProduct4792 (Entrez Gene)
IkKAGeneProduct1147 (Entrez Gene)
IkKBGeneProduct3551 (Entrez Gene)
IkKGGeneProduct8517 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MKP1GeneProduct1843 (Entrez Gene)
Med14GeneProduct9282 (Entrez Gene)
NFATGeneProduct4772 (Entrez Gene)
NFkBGeneProduct4790 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RXRGeneProduct6256 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
VDRGeneProduct7421 (Entrez Gene)
Vitamin DMetaboliteCHEBI:27300 (ChEBI)
p38GeneProduct1432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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