MAPK Cascade (Rattus norvegicus)

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1GiGqActivatedRap1GAPGb and GgApoptosisStress Activated PathwaysGrowth and MitogenesisNucleusp38 MAPK PathwayJunMap3k2Mapk3Map2NrasRasa3HrasMap2k6Map3k12Raf1Map2k4Map2k7Plcb3RrasMapk12Map2k1BrafMap2k2KrasElk1GDPMapk14Map3k3Map3k1ArafMapk10Mapk1GTPMBPMap2k3Map2k4RapGAPIISipa1


No description


This pathway was inferred from Homo sapiens pathway WP422(r21570) with a 87% conversion rate.

Quality Tags

Ontology Terms



  1. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC Scholia
  2. Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia


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95772view14:24, 19 January 2018MkutmonHomology conversion update
71797view20:33, 17 October 2013MaintBotAutomated update of data sources
71304view16:59, 17 October 2013MaintBotAutomated update of data sources
69419view19:02, 8 July 2013MaintBotUpdated to 2013 gpml schema
67439view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
62850view05:06, 3 May 2013MaintBotUpdated UniProt data source
41742view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
35462view11:54, 12 February 2010MichielAdded ref
34115view19:25, 9 December 2009MaintBotAutomatic update of empty xrefs
32434view17:14, 15 August 2009MaintBotFixed text labels
32103view13:46, 14 August 2009MaintBotFixed group labels
31455view21:12, 13 August 2009MaintBotFixed text labels
30956view00:44, 30 July 2009MaintBotConverted from Homo sapiens
21618view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:MAPK Cascade]] moved to [[Pathway:WP446]]: Moved to stable identifier
8246view13:46, 7 January 2008MaintBot[[Pathway:Rat:MAPK Cascade]] moved to [[Pathway:Rattus norvegicus:MAPK Cascade]]: Renaming species
7743view16:14, 18 December 2007MaintBotfixed category names
7276view12:41, 4 November 2007MaintBotAdded categories to GPML
19507view22:20, 22 May 2007I.Reyesgpml file for [[Rat:MAPK_Cascade]]
6573view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:MAPK_Cascade]]

External references


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NameTypeDatabase referenceComment
ArafGeneProduct64363 (Entrez Gene)
BrafGeneProduct114486 (Entrez Gene)
Elk1GeneProduct314436 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
KrasGeneProduct24525 (Entrez Gene)
MBPGeneProduct24547 (Entrez Gene)
Map2GeneProduct25595 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Map2k3GeneProduct303200 (Entrez Gene)
Map2k4GeneProduct287398 (Entrez Gene)
Map2k6GeneProduct114495 (Entrez Gene)
Map2k7GeneProduct363855 (Entrez Gene)
Map3k1GeneProduct116667 (Entrez Gene)
Map3k12GeneProduct25579 (Entrez Gene)
Map3k2GeneProduct171492 (Entrez Gene)
Map3k3GeneProduct303604 (Entrez Gene)
Mapk10GeneProduct25272 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk12GeneProduct60352 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
NrasGeneProduct24605 (Entrez Gene)
Plcb3GeneProduct29322 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
Rasa3GeneProduct29372 (Entrez Gene)
RrasGeneProduct361568 (Entrez Gene)
Sipa1GeneProduct361710 (Entrez Gene) not confirmed SwissProt ID - mu: SPA1 MOUSE

Annotated Interactions

No annotated interactions
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