PDGFRα and STMN1 cooperate to exacerbate the cytotoxic effects of vinblastine (Mus musculus)

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1Spindle assembly checkpoint(SAC)PolymerizationVinblastinePdgfraStmn1Mitotic slippageApoptosisDepolymerizationStmn1PP



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  1. Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, Ligon KL, Sarkaria JN, Gygi SP, Michor F, Mitchison TJ, Charest A; ''A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine.''; Nat Commun, 2018 PubMed Europe PMC Scholia


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98995view12:02, 20 October 2018EgonwReplaced a secondary ChEBI identifier.
98993view23:23, 19 October 2018KhanspersOntology Term : 'cell cycle pathway' added !
98992view23:22, 19 October 2018KhanspersOntology Term : 'glioblastoma multiforme' added !
98991view23:20, 19 October 2018KhanspersModified description
98990view23:20, 19 October 2018KhanspersModified description
98989view23:09, 19 October 2018KhanspersNew pathway

External references


NameTypeDatabase referenceComment
PdgfraGeneProductENSMUSG00000029231 (Ensembl)
Stmn1GeneProductENSMUSG00000028832 (Ensembl)
VinblastineMetaboliteCHEBI:9983 (ChEBI)

Annotated Interactions

No annotated interactions

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