EGF/EGFR Signaling Pathway (Homo sapiens)

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SHC1DAGPIP3PIP2Internalization, degradation and recycling of EGFRIP3PIP2CYNUCYNFKB pathwayRegulation of actin polymerizationEGF/EGFR Signaling PathwayCa2+ERK1/2, ERK5, p38MAPK, JNK and NFKB mediated gene expressionNUReleaseNUNUCYNUCYMAPK14JUNDFOSBIQSEC1PEBP1JUNSTAT3CDC42ELK4AP2S1RAC1SPRY2SH3KBP1PTK6SH3GL2PRKCBSTAM2PCNATWIST1FOXO4CSKPTPN11NCK1PLD1EGFREGFRPLCE1ERBB2RALGDSUSP8RALAARHGEF1BCAR1CRKPTPN5GAB2STAMBPPTPRRPLD2MAP2K1INPPL1GRB10MAPK8VAV1PLCG1INPP5DABL1RPS6KB1SOS1EGFPRKCAPLSCR1AP2B1DOK2NOS3STAT1SP1PIK3C2BFOSRPS6KA2ATF1PRKCIARF6MAP3K2MAP3K1ERRFI1JAK2BRAFRASA1GRB2EPN1STXBP1SOS2RIN1VAV3PTPN12ROCK1PIAS3GJA1ASAP1MAP2K5PTENPRKCDMAP3K3RPS6KA5RPS6KA3HGSABI1EPS8SHC1EIF4EBP1RICTORE2F1PRKCZSTAMFOXO1STAT5BMAPK1RAB5ARALBP1DNM1MAP2K2COX2MAP4K1KRASNEDD4NCOA3AP2A1GAB1EGFRCAMK2AMAPK3SYNJ1MAPK9PTK2BMYBL2GRIM19REPS2AKT1SH2D2ASH3GL3MAPK7CREB1ITCHATXN2RAP1AMAP3K4TNK2LIMK2PIK3R2MTORHRASCRKLIQGAP1USP6NLELK1NEDD8STAT5APIK3R1RPS6KA1CAV2RAF1NCK2JAK1EPS15SRCMEF2DEPS15L1PDPK1VAV2CAV1AURKASTMN1RALBPLSCR1PGTPPGTPPPpGTPPUbGTPPPPPPPPGTPPPPPPPPPPPPPPPPPPPPPPPPPPPPPGTPUbPPPGTPGTPPPPPPPEGFREGFRCBLBCBLCBLCSRCPGRB2PSOS1RALBP1CBLBCBLPCBLCPLD1PAK1PSTAT3STAT1PPSTAT5BPSTAT5APCFL1PTK2PEGFAP2M1PIAS3MEF2ASRCPXNEndosome/Multivesicular bodies/LysozomeHRASVAV2GTPPSP1PEPS8MEF2CRPS6KA3MAPK3MAPK1MAPK9PMAPK8PMAPK7MAP2K2MAP2K1NUCYCYNUNUNUCYNUCYCYProtein - protein dissociationReceptorProteinEnzyme ComplexmRNAProteinProteinLigandSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMolecule