EGF/EGFR Signaling Pathway (Homo sapiens)

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SHC1IP3DAGPIP2PIP2PIP3Internalization, degradation and recycling of EGFRNUNFKBEGFR signal transduction pathwayReleaseCYRegulation 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 bodies/LysozomeHRASVAV2GTPPSP1PEPS8MEF2CRPS6KA3MAPK3MAPK1MAPK9PMAPK8PMAPK7MAP2K2MAP2K1NUCYCYNUNUNUCYNUCYCYEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinmRNAProteinReceptorLigandDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage


Description

No description

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
111019view14:22, 30 June 2020L DupuisConverted interaction lines in legend to graphical lines
106392view21:27, 28 August 2019KhanspersModified description
105574view06:29, 9 August 2019KhanspersModified description
79266view20:32, 19 March 2015ZariChenged Identifier for PXN
78502view10:29, 7 January 2015MaintBotadded missing graphIds
72106view22:03, 24 October 2013AlexanderPicoadded xrefs
71357view18:35, 17 October 2013MaintBotAutomated update of data sources
70625view21:22, 16 August 2013MaintBotUpdated xrefs from Anatoly Urisman
67174view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
63177view20:30, 8 May 2013MaintBotUpdating gpml version
47973view14:23, 23 April 2012NetPathModified description
44600view21:09, 21 September 2011KhanspersUpdating content to NetSlim
44120view20:50, 24 August 2011KhanspersReverted to version '23:15, 1 March 2011' by Khanspers
44017view22:41, 22 August 2011Khanspers
44009view22:10, 22 August 2011KhanspersModified description
44008view22:05, 22 August 2011KhanspersModified description
44007view22:03, 22 August 2011KhanspersModified description
44006view22:00, 22 August 2011KhanspersUpdating pathway from NetSlim
41034view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35716view23:27, 12 February 2010AlexanderPico
35432view11:23, 12 February 2010MichielChanged literature reference
35428view11:06, 12 February 2010MichielAdded literature reference
35300view23:23, 11 February 2010NsalomonisModified description
21600view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:EGFR1 NetPath 4]] moved to [[Pathway:WP437]]: Moved to stable identifier
7996view13:46, 7 January 2008MaintBot[[Pathway:Human:EGFR1 NetPath 4]] moved to [[Pathway:Homo sapiens:EGFR1 NetPath 4]]: Renaming species
7621view16:05, 18 December 2007MaintBotfixed category names
7215view12:33, 4 November 2007MaintBotAdded categories to GPML
6309view22:17, 22 May 2007A.Pandeygpml file for [[Human:EGFR1_NetPath_4]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABI1GeneProduct10006 (Entrez Gene)
ABL1GeneProduct25 (Entrez Gene)
AKT1Protein207 (Entrez Gene)
AP2A1Protein160 (Entrez Gene)
AP2B1Protein163 (Entrez Gene)
AP2M1Protein1173 (Entrez Gene)
AP2S1Protein1175 (Entrez Gene)
ARF6GeneProduct382 (Entrez Gene)
ARHGEF1Protein9138 (Entrez Gene)
ASAP1GeneProduct50807
ATF1GeneProduct466 (Entrez Gene)
ATXN2GeneProduct6311 (Entrez Gene)
AURKAGeneProduct6790 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
CAV1Protein857 (Entrez Gene)
CAV2GeneProduct858
CBLGeneProduct867
CBLBGeneProduct868 (Enzyme Nomenclature)
CBLCGeneProduct23624 (Entrez Gene)
CDC42Protein998 (Entrez Gene)
CFL1Protein1072 (Entrez Gene)
COX2GeneProduct
CREB1GeneProduct1385 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CSKGeneProduct1445 (Entrez Gene)
DNM1Protein1759 (Entrez Gene)
DOK2Protein9046 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956
EGFRGeneProduct1956 (Entrez Gene)
EIF4EBP1GeneProduct1978
ELK1GeneProduct2002 (Entrez Gene)
ELK4GeneProduct2005 (Entrez Gene)
EPN1Protein29924 (Entrez Gene)
EPS15GeneProduct2060 (Entrez Gene)
EPS15L1Protein58513 (Entrez Gene)
EPS8GeneProduct2059 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
ERRFI1GeneProduct54206 (Entrez Gene)
FOSProtein2353 (Entrez Gene)
FOSBProtein2354 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO4GeneProduct4303 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GAB2GeneProduct9846 (Entrez Gene)
GJA1GeneProduct2697 (Entrez Gene)
GRB10GeneProduct2887
GRB2Protein2885 (Entrez Gene)
GRIM19GeneProduct51079 (Entrez Gene)
HGSGeneProduct9146 (Entrez Gene)
HRASGeneProduct3265
INPP5DProtein3635 (Entrez Gene)
INPPL1Protein3636 (Entrez Gene)
IQGAP1GeneProduct8826 (Entrez Gene)
IQSEC1GeneProduct9922 (Entrez Gene)
ITCHProtein83737 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
JUNDProtein3727 (Entrez Gene)
KRASProtein3845 (Entrez Gene)
LIMK2Protein3985 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP4K1Protein11184 (Entrez Gene)
MAPK14Protein1432 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5596 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8Protein5599 (Entrez Gene)
MAPK9Protein5601 (Entrez Gene)
MEF2AProtein207 (Entrez Gene)
MEF2CProtein5605 (Entrez Gene)
MEF2DGeneProduct160 (Entrez Gene)
MTORProtein207 (Entrez Gene)
MYBL2GeneProduct4605 (Entrez Gene)
NCK1GeneProduct4690 (Entrez Gene)
NCK2GeneProduct8440 (Entrez Gene)
NCOA3GeneProduct
NEDD4GeneProduct4737
NEDD8GeneProduct4738 (Entrez Gene)
NOS3GeneProduct
PAK1GeneProduct5338
PCNAGeneProduct5111 (Entrez Gene)
PDPK1Protein5170 (Entrez Gene)
PEBP1GeneProduct5037 (Entrez Gene)
PIAS3GeneProduct10401 (Entrez Gene)
PIK3C2BGeneProduct5287 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PIK3R2Protein5296 (Entrez Gene)
PLCE1Protein51196 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PLD1Protein5337 (Entrez Gene)
PLD2GeneProduct5338
PLSCR1GeneProduct5359 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCBGeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PTENGeneProduct5728 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTK6GeneProduct5753 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN12GeneProduct5782 (Entrez Gene)
PTPN5GeneProduct84867 (Entrez Gene)
PTPRRGeneProduct5801
PXNGeneProduct38326 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
ProteinProtein
RAB5AProtein5868 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RALAProtein5898 (Entrez Gene)
RALBProtein5899 (Entrez Gene)
RALBP1Protein10928 (Entrez Gene)
RALGDSProtein5900 (Entrez Gene)
RAP1AProtein5906 (Entrez Gene)
RASA15921 (Entrez Gene)
REPS2Protein9185 (Entrez Gene)
RICTORGeneProduct253260 (Entrez Gene)
RIN1Protein9610 (Entrez Gene)
ROCK1Protein
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
SH2D2AGeneProduct9047 (Entrez Gene)
SH3GL2GeneProduct6456 (Entrez Gene)
SH3GL3GeneProduct6457 (Entrez Gene)
SH3KBP1Protein30011 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SP1GeneProduct6667 (Entrez Gene)
SPRY2GeneProduct10253 (Entrez Gene)
SRCGeneProduct6714
STAM2Protein10254 (Entrez Gene)
STAMProtein8027 (Entrez Gene)
STAMBPGeneProduct10617 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
STXBP1GeneProduct6812 (Entrez Gene)
SYNJ1GeneProduct8867 (Entrez Gene)
TNK2GeneProduct10188 (Entrez Gene)
TWIST1GeneProduct7291 (Entrez Gene)
USP6NLProtein9712 (Entrez Gene)
USP8GeneProduct9101 (Entrez Gene)
VAV1Protein7409 (Entrez Gene)
VAV2Protein7410 (Entrez Gene)
VAV3Protein10451 (Entrez Gene)
mRNAProtein

Annotated Interactions

No annotated interactions

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