EGF/EGFR Signaling Pathway (Homo sapiens)

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Revision as of 23:23, 11 February 2010 by Nsalomonis (Talk | contribs)
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AcetylationPMCYMAMACYPMCYPMPMProteins in a complex interactionNUMolecular associationRecruitmentPhosphorylationCYEnzyme complexPalmitoylationPMNUNUNUCYCYGlycosylationReaction through unknown mechanisms/moleculesMACYAutophosphorylationCYPMMethylationCYReceptorNUMAMAActivationNUNUNUCYProteolytic cleavageMAMACYNucleusDAutodephosphorylationPMMADPMMAMAPMERExtracellularGene SymbolDephosphorylationENCYDeacetylationCYMAPMMAUbiquitinationNUMAPMNUCYPMCYNUMACYENCYCYMACYNUMAENPMMTInhibitionCYPMCYCYLigandDeubiquitinationGOPMPlasma membraneNUCYMAPMCYMADemethylationMolecule in the pathwayCYMACYPMTranslocationMACYDesumoylationCYMAMitochondrionEndosomeCYNUCYPMAccession Number : NetPath 4; cellmap:4NUEndoplasmic reticulumGolgi apparatus(Protein-protein interaction)NUNUPMCYCYControlSumoylationCYDNUECPMCytoplasmPMNUNUPMCYCYCREB1JUNDSHC1AKT1SNRPD2HDAC1SHOC2VAV3CAV1SMAD3RAB5APLEC1EPS15SP1CBLBDUSP1KRT8STAT3EPS8GIT1GAB1SH2D3CPLSCR1STAT1SOS1HRASPRKCACAV2EEF1A1PLD1GRB7PTPN11PIK3R1DIP13BEGFGRB2VAV1MAP2K3CBLCMAPK1PTPN6MAP2K2MAPK14BCAR1EGFRSH3GL2FOXO1APTK6HIST3H3STAT5BRALGDSKRT18GRB10PLCG2PTPN5STXBP1USP6NLCTNND1NRASPIK3C2BPTPN12ELK4RIPK1MAP3K3EEF1A1CRKLRPS6KA3ABI1SRCMAP2K1ZNF259CASP9CRKMAPK1CEBPAJAK1GRB14PRKCB1TNIP1SH3GL2REPS2APPLSH3BGRLPLD1MAPK8DOK2MAP2K1MTA2MAP2K5FOXO1AREPS1ARF4EGFNCK2GAB2SOS2PXNPLD2BCAR1JUNELF3MAPK3FOSRPS6KA1SOCS1MAP3K4MCF2PAK1PITPNAPRKCACDC42MAP3K2PTPN6KLF11ITCHMAP3K2ELK1AP2A1SMAD2PRKAR1ASTAT2STAT2CSKPTK2BSMAD2ELF3MAP3K14DUSP1CEBPBPRKCMNDUFA13MAPK7PIK3R2JAK2ARF4SNCAWNK1RALBP1RBBP7APPLEGFRRAC1CBLPLCG1GJA1RGS16ERRFI1YWHABPIK3CGRAF1SPRY2MAP3K1PIK3CBDNM1PEBP1PLCG1SIN3ARAF1SH3GL3PRKCISOCS3SH3KBP1PLCG2STAT5AHDZNF259PTPRREGFRSTAT3SMAD3TGIFTNK2KRAS2RPS6KA2DIP13BRASA1SH2D3CSTXBP1SHC1ARAFMAP2K7INPPL1KRT7RFXANKPRKCZNCK1EGFRAPPLSTAT1RPS6KA5PIK3CADDEF1STAT3GAB1EPS15L1STAT5APIK3CDCAMK2AMYCHAT1EPPK1EPS15ATF1EGFEPN1SPRY2PRKCGARF4VAV2CEACAM1PKN2STAT1RALBRPS6KA3KRT17HIP1WASLPIK3R3


Description

"The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module." Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
111019view14:22, 30 June 2020L DupuisConverted interaction lines in legend to graphical lines
106392view21:27, 28 August 2019KhanspersModified description
105574view06:29, 9 August 2019KhanspersModified description
79266view20:32, 19 March 2015ZariChenged Identifier for PXN
78502view10:29, 7 January 2015MaintBotadded missing graphIds
72106view22:03, 24 October 2013AlexanderPicoadded xrefs
71357view18:35, 17 October 2013MaintBotAutomated update of data sources
70625view21:22, 16 August 2013MaintBotUpdated xrefs from Anatoly Urisman
67174view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
63177view20:30, 8 May 2013MaintBotUpdating gpml version
47973view14:23, 23 April 2012NetPathModified description
44600view21:09, 21 September 2011KhanspersUpdating content to NetSlim
44120view20:50, 24 August 2011KhanspersReverted to version '23:15, 1 March 2011' by Khanspers
44017view22:41, 22 August 2011Khanspers
44009view22:10, 22 August 2011KhanspersModified description
44008view22:05, 22 August 2011KhanspersModified description
44007view22:03, 22 August 2011KhanspersModified description
44006view22:00, 22 August 2011KhanspersUpdating pathway from NetSlim
41034view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35716view23:27, 12 February 2010AlexanderPico
35432view11:23, 12 February 2010MichielChanged literature reference
35428view11:06, 12 February 2010MichielAdded literature reference
35300view23:23, 11 February 2010NsalomonisModified description
21600view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:EGFR1 NetPath 4]] moved to [[Pathway:WP437]]: Moved to stable identifier
7996view13:46, 7 January 2008MaintBot[[Pathway:Human:EGFR1 NetPath 4]] moved to [[Pathway:Homo sapiens:EGFR1 NetPath 4]]: Renaming species
7621view16:05, 18 December 2007MaintBotfixed category names
7215view12:33, 4 November 2007MaintBotAdded categories to GPML
6309view22:17, 22 May 2007A.Pandeygpml file for [[Human:EGFR1_NetPath_4]]

External references

DataNodes

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NameTypeDatabase referenceComment
ABI1GeneProduct10006 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
AP2A1GeneProduct160 (Entrez Gene)
APPLGeneProduct26060 (Entrez Gene)
ARAFGeneProduct369 (Entrez Gene)
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ATF1GeneProduct466 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
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DIP13BGeneProduct55198 (Entrez Gene)
DNM1GeneProduct1759 (Entrez Gene)
DOK2GeneProduct9046 (Entrez Gene)
DUSP1GeneProduct1843 (Entrez Gene)
EEF1A1GeneProduct1915 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
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JUNGeneProduct3725 (Entrez Gene)
JUNDGeneProduct3727 (Entrez Gene)
KLF11GeneProduct8462 (Entrez Gene)
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KRT17GeneProduct3872 (Entrez Gene)
KRT18GeneProduct3875 (Entrez Gene)
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PTK2BGeneProduct2185 (Entrez Gene)
PTK6GeneProduct5753 (Entrez Gene)
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RAC1GeneProduct5879 (Entrez Gene)
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RALBGeneProduct5899 (Entrez Gene)
RALBP1GeneProduct10928 (Entrez Gene)
RALGDSGeneProduct5900 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RBBP7GeneProduct5931 (Entrez Gene)
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RFXANKGeneProduct8625 (Entrez Gene)
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RIPK1GeneProduct8737 (Entrez Gene)
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RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
SH2D3CGeneProduct10044 (Entrez Gene)
SH3BGRLGeneProduct6451 (Entrez Gene)
SH3GL2GeneProduct6456 (Entrez Gene)
SH3GL3GeneProduct6457 (Entrez Gene)
SH3KBP1GeneProduct30011 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
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SIN3AGeneProduct25942 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SNCAGeneProduct6622 (Entrez Gene)
SNRPD2GeneProduct6633 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
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SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
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WNK1GeneProduct65125 (Entrez Gene)
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ZNF259GeneProduct8882 (Entrez Gene)

Annotated Interactions

No annotated interactions
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