Eicosanoid metabolism via Lipo Oxygenases (LOX) (Mus musculus)

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Alox5LTA4Arachidonic acidCyp4a105-HEDHLta4h15-HpETE15-HETE8-HpETE8-HETE15-oxoETEAlox15LXA4Hpgd12-HpETE12-HETE12-oxoETEAlox12HXB3HXA3TXA3TXB3HXEH12-HEDHLXB4LTB412-epi-LTB46-trans-12-epi-delta-LTB46-trans-delta-LTB4LTC4LTD4LTE4EXC4EXD4EXE420-hydroxy-LTB420-carboxy-LTB418-carboxy-dinor-LTB411-trans-LTC411-trans-LTD411-trans-LTE45-HpETE5-HETE5-oxoETE15-oxo-LXA413,14-dihydro-15-oxo-LXA412-oxo-LTB4Ltc4sCyp4a12aCyp4a12bCyp4f14Cyp4f18Acox1Acox2Acox3EhhadhAcaa1aGgt1Ggt5Dpep1Dpep2Ptgr1Ptgr2Alox12Alox5Ptgr1Ptgr2HpgdAlox5


This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [1].

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX), lipooxygenases(LOX), or cytochrome P450 monooxygenases (CYP).

This pathway visualises the second route, via LOX.

Quality Tags

Ontology Terms



  1. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC Scholia
  2. Moreno JJ; ''New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  3. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''''; , PubMed Europe PMC Scholia


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106329view08:41, 21 August 2019DeSlAdded general LipidMaps publication.
106273view14:31, 19 August 2019DeSlModified description
106272view14:31, 19 August 2019DeSlModified description
102924view12:46, 29 January 2019DeSlConnected interactions differently for readability
102923view12:43, 29 January 2019DeSlLast layout changes
102921view12:38, 29 January 2019DeSlAdded info from second lit. ref
102917view14:53, 28 January 2019DeSlAdded info from lit ref
102916view12:35, 28 January 2019DeSlChanged layout, checked all reactions according to LipidMaps drawing
102894view16:14, 26 January 2019EgonwModified description
102889view15:48, 25 January 2019DeSlModified title
102887view15:46, 25 January 2019DeSlOntology Term : 'eicosanoid metabolic pathway' added !
102886view15:46, 25 January 2019DeSlOntology Term : 'PW:0000002' removed !
102885view15:46, 25 January 2019DeSlOntology Term : 'lipoxygenase mediated pathway of arachidonic acid metabolism' added !
102880view15:45, 25 January 2019DeSlModified description
102878view15:44, 25 January 2019DeSlModified description
98608view12:41, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98578view15:54, 17 September 2018EoinfahyNew pathway

External references


View all...
NameTypeDatabase referenceComment
11-trans-LTC4MetaboliteLMFA03020020 (LIPID MAPS)
11-trans-LTD4MetaboliteLMFA03020021 (LIPID MAPS)
11-trans-LTE4MetaboliteLMFA03020022 (LIPID MAPS)
12-HETEMetaboliteLMFA03060088 (LIPID MAPS)
12-HpETEMetaboliteLMFA03060013 (LIPID MAPS)
12-epi-LTB4MetaboliteLMFA03020015 (LIPID MAPS)
12-oxo-LTB4MetaboliteLMFA03020024 (LIPID MAPS)
12-oxoETEMetaboliteLMFA03060019 (LIPID MAPS)
13,14-dihydro- 15-oxo-LXA4MetaboliteLMFA03040008 (LIPID MAPS)
15-HETEMetaboliteLMFA03060087 (LIPID MAPS)
15-HpETEMetaboliteLMFA03060014 (LIPID MAPS)
15-oxo-LXA4MetaboliteLMFA03040009 (LIPID MAPS)
15-oxoETEMetaboliteLMFA03060051 (LIPID MAPS)
18-carboxy- dinor-LTB4MetaboliteLMFA03020057 (LIPID MAPS)
20-carboxy-LTB4MetaboliteLMFA03020016 (LIPID MAPS)
20-hydroxy-LTB4MetaboliteLMFA03020018 (LIPID MAPS)
5-HETEMetaboliteLMFA03060084 (LIPID MAPS)
5-HpETEMetaboliteLMFA03060108 (LIPID MAPS)
5-oxoETEMetaboliteLMFA03060011 (LIPID MAPS)
6-trans-12-epi-delta-LTB4MetaboliteLMFA03020014 (LIPID MAPS)
6-trans-delta-LTB4MetaboliteLMFA03020013 (LIPID MAPS)
8-HETEMetaboliteLMFA03060086 (LIPID MAPS)
8-HpETEMetaboliteLMFA03060073 (LIPID MAPS)
Acaa1aGeneProduct113868 (Entrez Gene)
Acox1GeneProduct11430 (Entrez Gene)
Acox2GeneProduct93732 (Entrez Gene)
Acox3GeneProduct80911 (Entrez Gene)
Alox12GeneProduct11684 (Entrez Gene)
Alox15GeneProduct11687 (Entrez Gene)
Alox5GeneProduct11689 (Entrez Gene)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Cyp4a10GeneProduct13117 (Entrez Gene)
Cyp4a12aGeneProduct277753 (Entrez Gene)
Cyp4a12bGeneProduct13118 (Entrez Gene)
Cyp4f14GeneProduct64385 (Entrez Gene)
Cyp4f18GeneProduct72054 (Entrez Gene)
Dpep1GeneProduct13479 (Entrez Gene)
Dpep2GeneProduct319446 (Entrez Gene)
EXC4MetaboliteLMFA03020031 (LIPID MAPS)
EXD4MetaboliteLMFA03020032 (LIPID MAPS)
EXE4MetaboliteLMFA03020033 (LIPID MAPS)
EhhadhGeneProduct74147 (Entrez Gene)
Ggt1GeneProduct14598 (Entrez Gene)
Ggt5GeneProduct23887 (Entrez Gene)
HXA3MetaboliteLMFA03090005 (LIPID MAPS)
HXB3MetaboliteLMFA03090003 (LIPID MAPS)
HpgdGeneProduct15446 (Entrez Gene)
LTA4MetaboliteLMFA03020023 (LIPID MAPS)
LTB4MetaboliteLMFA03020001 (LIPID MAPS)
LTC4MetaboliteLMFA03020003 (LIPID MAPS)
LTD4MetaboliteLMFA03020006 (LIPID MAPS)
LTE4MetaboliteLMFA03020002 (LIPID MAPS)
LXA4MetaboliteLMFA03040001 (LIPID MAPS)
LXB4MetaboliteLMFA03040002 (LIPID MAPS)
Lta4hGeneProduct16993 (Entrez Gene)
Ltc4sGeneProduct17001 (Entrez Gene)
Ptgr1GeneProduct67103 (Entrez Gene) AKA Ltb4dh
Ptgr2GeneProduct77219 (Entrez Gene) AKA Zadh1
TXA3MetaboliteLMFA03030005 (LIPID MAPS)
TXB3MetaboliteLMFA03030006 (LIPID MAPS)

Annotated Interactions

No annotated interactions

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