Non-genomic actions of 1,25 dihydroxyvitamin D3 (Homo sapiens)

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1Plasma membraneStressTranscription of:Cell death?TLR2/4/8ligandsTranscription of anti-viral genesPLCB3STAT1IFI27LPLCB1CD40LGPIK3CBPRKCGRXRBPIK3CDPIK3C3OAS3TLR4JAK1PIK3CACaMK2DIFNR gammaAKT1DAGVDRPIK3CGAAIKK2PIK3R5Caveolin-1OAS2STAT2PLCB425DPLCG1PRKCEPRKCATLR8PRKCQAKT2PLCE1CaMK2GETS1PIK3R3PLCG2PLCD1PMAMED1PLA2G1BPIK3R2PIK3C2APRKCBSP3AKT3RXRGPIK3C2G1,25DCaMK2BRXRAIFI44LISG15TLR2VSECaMK2ACYP27B1OAS1PIK3R1PIK3R4PLCD4PLCD3PLCB2PIK3C2BPRKCDRSAD2PRKCH25DVDRnCD40INF gammaINF alphaIFNR alphaCYP27B1VDRTYK2STAT2STAT1AA1,25DVDRm/nVDRVDRnSP1VDRcJUNVDR transcriptionKRASHRASNRASMAPK3MAPK1MAPK7MAPK8MAPK9PKC zetaVDRnNFKB1RELBNFKB2NFKB1RELBNFKB2MAPK8MAPK9TNFR1TNFMAPK11MAPK14MAPK13MAPK12MAPK11MAPK14MAPK13MAPK12Gene transcriptionCYP24A1CAMPDEFB4ANOD2VDRCCL2CXCL8IL-6Gene transcriptionNucleusIon channels


Description

The pathway summarizes the knowlegde on the non-genomic actions of the hormonally active form of vitamin D, 1,25 dihydroxyvitamin D3. It is based the pathway figure published by Hii CS and Ferrante (Nutrients, 2016).

Quality Tags

Ontology Terms

 

Bibliography

  1. Hii CS, Ferrante A; ''The Non-Genomic Actions of Vitamin D.''; Nutrients, 2016 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107169view14:25, 17 September 2019MaintBotChEBI identifier normalization
98497view08:39, 13 September 2018SusanModified description
98496view08:26, 13 September 2018SusanModified description
98495view08:23, 13 September 2018SusanOntology Term : 'vitamin D signaling pathway' added !
98494view08:20, 13 September 2018SusanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1,25DMetaboliteHMDB0001903 (HMDB)
25DMetaboliteHMDB0003550 (HMDB)
AAMetaboliteHMDB0001043 (HMDB)
AKT1GeneProductENSG00000142208 (GenBank)
AKT2GeneProductENSG00000105221 (GenBank)
AKT3GeneProductENSG00000117020 (GenBank)
CAMPGeneProductENSG00000164047 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CD40GeneProductENSG00000101017 (Ensembl)
CD40LGGeneProductENSG00000102245 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CYP24A1GeneProductENSG00000019186 (Ensembl)
CYP27B1GeneProductENSG00000111012 (Ensembl)
CaMK2AGeneProductENSG00000070808 (Ensembl)
CaMK2BGeneProductENSG00000058404 (Ensembl)
CaMK2DGeneProductENSG00000145349 (Ensembl)
CaMK2GGeneProductENSG00000148660 (Ensembl)
Caveolin-1ProteinQ03135 (Uniprot-TrEMBL)
DAGGeneProduct
DEFB4AGeneProductENSG00000171711 (Ensembl)
ETS1GeneProductENSG00000134954 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IFI27LGeneProductENSG00000119632 (Ensembl)
IFI44LGeneProductENSG00000137959 (Ensembl)
IFNR alphaGeneProduct
IFNR gammaGeneProduct
IKK2GeneProductENSG00000104365 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
INF alphaProteinP01563 (Uniprot-TrEMBL)
INF gammaProteinP01579 (Uniprot-TrEMBL)
ISG15GeneProductENSG00000187608 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK7GeneProductENSG00000166484 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MED1GeneProductENSG00000125686 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NOD2GeneProductENSG00000167207 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
OAS1GeneProductENSG00000089127  (Ensembl)
OAS2GeneProductENSG00000111335 (Ensembl)
OAS3GeneProductENSG00000111331  (Ensembl)
PIK3C2AGeneProductENSG00000011405 (GenBank)
PIK3C2BGeneProductENSG00000133056 (GenBank)
PIK3C2GGeneProductENSG00000139144  (GenBank)
PIK3C3GeneProductENSG00000078142  (GenBank)
PIK3CAGeneProductENSG00000121879 (GenBank)
PIK3CBGeneProductENSG00000051382 (GenBank)
PIK3CDGeneProductENSG00000171608 (GenBank)
PIK3CGGeneProductENSG00000105851 (GenBank)
PIK3R1GeneProductENSG00000145675 (GenBank)
PIK3R2GeneProductENSG00000105647 (GenBank)
PIK3R3GeneProductENSG00000117461 (GenBank)
PIK3R4GeneProductENSG00000196455 (GenBank)
PIK3R5GeneProductENSG00000141506 (GenBank)
PKC zetaGeneProductENSG00000067606 (Ensembl)
PLA2G1BGeneProductENSG00000170890 (GenBank)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PLCD1GeneProductENSG00000187091 (Ensembl)
PLCD3GeneProductENSG00000187091 (Ensembl)
PLCD4GeneProductENSG00000187091 (Ensembl)
PLCE1GeneProductENSG00000138193 (Ensembl)
PLCG1GeneProductENSG00000187091 (Ensembl)
PLCG2GeneProductENSG00000197943 (Ensembl)
PMAMetabolite37537 (ChEBI)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
PRKCDGeneProductENSG00000163932 (Ensembl)
PRKCEGeneProductENSG00000171132 (Ensembl)
PRKCGGeneProductENSG00000126583 (Ensembl)
PRKCHGeneProductENSG00000027075 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RELBGeneProductENSG00000104856 (Ensembl)
RSAD2GeneProductENSG00000134321 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SP3GeneProductENSG00000172845 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFR1GeneProductENSG00000067182 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)
VDRGeneProductENSG00000111424 (Ensembl)
VDRm/nGeneProductENSG00000111424 (Ensembl)
VDRnGeneProductENSG00000111424 (Ensembl)
VSEGeneProductVSE
cJUNGeneProductENSG00000177606 (Ensembl)

Annotated Interactions

No annotated interactions

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