Thermogenesis (Homo sapiens)

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NucleusBrown or beige adipocytemTORC1Lipid dropletSympathetic nervous systemLow AMP/ATPHypothalamic AMPKSecretedHeatComplexesI II III IVcGMPGCGCPT1AACTL6BRPTORADRB3CPT2ACSL1RHEBPPARGGRB2PPARGC1AGNASATF2NADHSLC25A20ANPcAMPEstradiol-17betaPLIN1L-noradrenalineCREB3BMP8AH+RPS6MAP3K5KDM3BKDM1ACarnitineZNF516Regulation oflipolysis in adipocyteRPS6KA3DGRPS6KA6UCP1fatty acidCoenzyme AHRASARID1BH+PRDM16NicotineADPUCP1Acyl-CoASIRT6PRKG13,3',5'-TriiodothyroninemTOR SignalingPathwayFADH2RPS6KB1FRS2PRKAG22-ArachidonoylglycerolRPS6KA1AcylcarnitinecAMP SignalingPathwayFGF21TSC1GlycerolMGLLSLC25A29TGMGAcetyl-CoAElectron Transport ChainArachidonylethanolamidePRKAG3PRKACAFGF21RPS6KA2TCA CyclePNPLA2ADCY1PPPPPADCY2ADCY3ADCY5ADCY6ADCY7ADCY8ADCY9ADCY4ADCY10CNR1NPR1KLBFGFR1BNPSOS1SOS2KRASNRASTSC2PMTORMLST8AKT1S1RPS6KB2PPRKG2LIPEPPRKACBPRKACGMAPK SignalingPathwayMAP2K3PMAPK14PMAPK11PMAPK13PMAPK12PCREB1CREB3L4CREB3L2CREB3L3CREB3L1CREB5KDM3AACTBSMARCA2SMARCA4SMARCB1SMARCC1SMARCC2SMARCD1SMARCD2SMARCD3SMARCE1ACTG1DPF3DPF1ARID1AACTL6AUCP1fatty acidATPAcyl-CoAAcylcarnitineCoenzyme ACarnitineH+ACSL3ACSL4ACSL5ACSL6CPT1BCPT1COxidativePhosphorylationATPaseH+H+H+H+HypothalamusColdOverfeedingPRKAA1PRKAA2PRKAB1PRKAB2PRKAG1EndocannabinoidsBMP8B


Description

Thermogenesis is an essential process of heat production in warm-blooded animals and some plants.

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Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
106178view12:07, 16 August 2019MaintBotHMDB identifier normalization
102774view08:51, 24 January 2019EgonwMissed one.
102772view21:11, 23 January 2019EgonwFixed the casing of two ChEBI identifiers (prefix should be CHEBI: instead of ChEBI:)
98055view06:12, 13 July 2018Fehrhartadded ID for MAPK signaling pathway
98002view10:12, 30 June 2018EgonwAdded an identifier for endocannabinoids.
98001view09:22, 30 June 2018EgonwI missed one :(
98000view08:15, 30 June 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97999view20:05, 29 June 2018KhanspersOntology Term : 'electron transport chain pathway' added !
97998view20:04, 29 June 2018KhanspersOntology Term : 'brown fat cell' added !
97997view20:04, 29 June 2018KhanspersOntology Term : 'beige adipocyte' added !
97996view20:03, 29 June 2018KhanspersAdded endocannabinoids etc
97995view19:43, 29 June 2018Khansperswork in progress
97994view19:24, 29 June 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-ArachidonoylglycerolMetaboliteCHEBI:34261 (ChEBI)
3,3',5'-TriiodothyronineMetaboliteCHEBI:11684 (ChEBI)
ACSL1GeneProductENSG00000151726 (Ensembl)
ACSL3GeneProductENSG00000123983 (Ensembl)
ACSL4GeneProductENSG00000068366 (Ensembl)
ACSL5GeneProductENSG00000197142 (Ensembl)
ACSL6GeneProductENSG00000164398 (Ensembl)
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTL6AGeneProductENSG00000136518 (Ensembl)
ACTL6BGeneProductENSG00000077080 (Ensembl)
ADCY10GeneProductENSG00000143199 (Ensembl)
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY2GeneProduct108 (Entrez Gene)
ADCY3GeneProduct109 (Entrez Gene)
ADCY4GeneProductENSG00000129467 (Ensembl)
ADCY5GeneProductENSG00000173175 (Ensembl)
ADCY6GeneProductENSG00000174233 (Ensembl)
ADCY7GeneProductENSG00000121281 (Ensembl)
ADCY8GeneProductENSG00000155897 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
ADPMetaboliteCHEBI:2342 (ChEBI)
ADRB3GeneProductENSG00000188778 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
ANPMetaboliteCHEBI:80233 (ChEBI)
ARID1AGeneProductENSG00000117713 (Ensembl)
ARID1BGeneProductENSG00000049618 (Ensembl)
ATF2GeneProductENSG00000115966 (Ensembl)
ATPMetaboliteCHEBI:2359 (ChEBI)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
Acyl-CoAMetaboliteCHEBI:2455 (ChEBI)
AcylcarnitineMetaboliteChEBI:75659 (ChEBI)
ArachidonylethanolamideMetaboliteCHEBI:2700 (ChEBI)
BMP8AGeneProductENSG00000183682 (Ensembl)
BMP8BGeneProductENSG00000116985 (Ensembl)
BNPMetaboliteCHEBI:80234 (ChEBI)
CNR1GeneProductENSG00000118432 (Ensembl)
CPT1AGeneProductENSG00000110090 (Ensembl)
CPT1BGeneProductENSG00000205560 (Ensembl)
CPT1CGeneProductENSG00000169169 (Ensembl)
CPT2GeneProductENSG00000157184 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
CREB3GeneProductENSG00000107175 (Ensembl)
CREB3L1GeneProduct90993 (Entrez Gene)
CREB3L2GeneProductENSG00000182158 (Ensembl)
CREB3L3GeneProductENSG00000060566 (Ensembl)
CREB3L4GeneProductENSG00000143578 (Ensembl)
CREB5GeneProductENSG00000146592 (Ensembl)
CarnitineMetaboliteCHEBI:3424 (ChEBI)
Coenzyme AMetaboliteCHEBI:3771 (ChEBI)
DGMetaboliteCHEBI:4481 (ChEBI)
DPF1GeneProductENSG00000011332 (Ensembl)
DPF3GeneProductENSG00000205683 (Ensembl)
Electron Transport ChainPathwayWP111 (WikiPathways)
Estradiol-17betaMetaboliteCHEBI:4864 (ChEBI)
FADH2MetaboliteCHEBI:4957 (ChEBI)
FGF21GeneProductENSG00000105550 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FRS2GeneProductENSG00000166225 (Ensembl)
GCGGeneProductENSG00000115263 (Ensembl)
GNASGeneProductENSG00000087460 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GlycerolMetaboliteCHEBI:5448 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
HRASGeneProductENSG00000174775 (Ensembl)
KDM1AGeneProductENSG00000004487 (Ensembl)
KDM3AGeneProductENSG00000115548 (Ensembl)
KDM3BGeneProductENSG00000120733 (Ensembl)
KLBGeneProductENSG00000134962 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
L-noradrenalineMetaboliteCHEBI:18357 (ChEBI)
LIPEGeneProductENSG00000079435 (Ensembl)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAPK Signaling PathwayPathway
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MGMetaboliteCHEBI:35759 (ChEBI)
MGLLGeneProductENSG00000074416 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
NADHMetaboliteCHEBI:7423 (ChEBI)
NPR1GeneProductENSG00000169418 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
NicotineMetaboliteCHEBI:17688 (ChEBI)
Oxidative PhosphorylationPathwayWP623 (WikiPathways)
PLIN1GeneProductENSG00000166819 (Ensembl)
PNPLA2GeneProductENSG00000177666 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRDM16GeneProductENSG00000142611 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PRKG1GeneProductENSG00000185532 (Ensembl)
PRKG2GeneProductENSG00000138669 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RPS6GeneProductENSG00000137154 (Ensembl)
RPS6KA1GeneProductENSG00000117676 (Ensembl)
RPS6KA2GeneProductENSG00000071242 (Ensembl)
RPS6KA3GeneProductENSG00000177189 (Ensembl)
RPS6KA6GeneProductENSG00000072133 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPS6KB2GeneProductENSG00000175634 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
Regulation of

lipolysis in

adipocyte
Pathway
SIRT6GeneProductENSG00000077463 (Ensembl)
SLC25A20GeneProductENSG00000178537 (Ensembl)
SLC25A29GeneProductENSG00000197119 (Ensembl)
SMARCA2GeneProductENSG00000080503 (Ensembl)
SMARCA4GeneProductENSG00000127616 (Ensembl)
SMARCB1GeneProductENSG00000099956 (Ensembl)
SMARCC1GeneProductENSG00000173473 (Ensembl)
SMARCC2GeneProductENSG00000139613 (Ensembl)
SMARCD1GeneProductENSG00000066117 (Ensembl)
SMARCD2GeneProductENSG00000108604 (Ensembl)
SMARCD3GeneProductENSG00000082014 (Ensembl)
SMARCE1GeneProductENSG00000073584 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCA CyclePathwayWP78 (WikiPathways)
TGMetaboliteCHEBI:75844 (ChEBI)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
UCP1GeneProductENSG00000109424 (Ensembl)
ZNF516GeneProductENSG00000101493 (Ensembl)
cAMP Signaling PathwayPathway
cAMPMetaboliteCHEBI:1325 (ChEBI)
cGMPMetaboliteCHEBI:1327 (ChEBI)
fatty acidMetaboliteCHEBI:35366 (ChEBI)
mTOR Signaling PathwayPathwayWP1471 (WikiPathways)

Annotated Interactions

No annotated interactions

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