miRNA degrading enzymes (Homo sapiens)

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1, 25'-PmiRNAPNPT1RRP41XRN13'-P


"In cultured human cells, ribosomal RNA processing protein 41 (RRP41) and polynucleotide phosphorylase (PNPT1) degrade specific miRNAs in the 3'-to-5'direction." Großhans H. et al 2012


"MicroRNAs (miRNAs) are short (∼22 nucleotide) RNAs that are important for the regulation of numerous biological processes. Accordingly, the expression of miRNAs is itself tightly controlled by mechanisms acting at the level of transcription as well as processing of miRNA precursors. Recently, active degradation of mature miRNAs has been identified as another mechanism that is important for miRNA homeostasis. Here we review the molecular factors and cellular conditions that promote miRNA turnover. We also discuss what is known about the physiological relevance of miRNA decay." Großhans H. et al 2012

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  1. Rüegger S, Großhans H; ''MicroRNA turnover: when, how, and why.''; Trends Biochem Sci, 2012 PubMed Europe PMC Scholia
  2. Zhang Z, Qin YW, Brewer G, Jing Q; ''MicroRNA degradation and turnover: regulating the regulators.''; Wiley Interdiscip Rev RNA, 2012 PubMed Europe PMC Scholia


97927view08:57, 25 June 2018MadeomugaModified description
97923view08:47, 25 June 2018MadeomugaNew pathway

External references


NameTypeDatabase referenceComment
PNPT1GeneProductENSG00000138035 (Ensembl)
RRP41GeneProductQ9NPD3 (Uniprot-TrEMBL)
XRN1GeneProductENSG00000114127 (Ensembl)

Annotated Interactions

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