Wnt signaling (Homo sapiens)

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Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.

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Ontology Terms



  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC Scholia


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116549view12:48, 7 May 2021EweitzModified title
115436view10:55, 19 February 2021DeSlRemoved last modified item + licence
114092view09:11, 22 December 2020EgonwThree more pathways clickable
106791view13:27, 17 September 2019MaintBotHMDB identifier normalization
106439view23:28, 28 August 2019KhanspersModified description
105468view05:15, 8 August 2019KhanspersModified description
102324view08:26, 20 December 2018FehrhartChanged title due to overlap with other pathway
94896view20:49, 11 October 2017Khanspersadded state information
94895view20:34, 11 October 2017Khanspersdetails
94894view20:23, 11 October 2017Khanspersdefined central part
94893view20:06, 11 October 2017KhanspersAdded PCP arm
94892view19:49, 11 October 2017Khanspersadded PCP arm
94891view19:29, 11 October 2017Khanspersoverhaul in progress
94871view20:45, 10 October 2017Khanspersoverhaul in progress
94854view23:37, 9 October 2017Khanspersoverhaul in progress
94851view23:05, 9 October 2017Khanspersoverhaul in progress
90292view23:11, 2 November 2016AlexanderPicoOntology Term : 'Wnt signaling, canonical pathway' added !
79854view13:40, 20 April 2015Mkutmonfixed unconnected lines
79528view11:10, 24 March 2015Zariadded ID for LRP5,LRP6,KREM1,RYK,ROR1 and ROR2
78532view10:30, 7 January 2015MaintBotadded missing graphIds
71365view18:36, 17 October 2013MaintBotAutomated update of data sources
70035view02:00, 12 July 2013AlexanderPicoFixed pathway xrefs
68920view17:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
45008view17:39, 6 October 2011KhanspersOntology Term : 'Wnt signaling pathway' added !
43042view21:46, 30 May 2011EwexlerMYWNT
43041view21:38, 30 May 2011EwexlerMYWNT
43040view21:28, 30 May 2011EwexlerPeriodical save, work in progress
43000view07:22, 26 May 2011Thomaschanged arrow types for catenin -> TCF interaction
41067view23:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
38838view17:23, 24 September 2010Khanspers
38682view17:51, 23 September 2010KhanspersLinked to pathways, changed t-bar to mim-inhibition and changed compartment graphics
37766view22:30, 1 July 2010KhanspersAdded nucleus
35114view13:21, 11 February 2010Thomasadded literature
35105view13:14, 11 February 2010ThomasModified description
33134view22:16, 26 October 2009Khansperswork on connectors
32428view17:12, 15 August 2009MaintBotFixed text labels
32091view13:42, 14 August 2009MaintBotFixed group labels
28695view01:36, 25 February 2009AlexanderPicoredefined complexes and groups
21582view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Wnt signaling]] moved to [[Pathway:WP428]]: Moved to stable identifier
14075view10:19, 21 May 2008MartijnVanIerselall linked up
13294view18:20, 17 May 2008AlexanderPicogrouped and reconnected top half
12982view10:59, 17 May 2008MaintBotSticky edges patch by Sjoerd
8488view13:46, 7 January 2008MaintBot[[Pathway:Human:Wnt signaling]] moved to [[Pathway:Homo sapiens:Wnt signaling]]: Renaming species
7860view16:24, 18 December 2007MaintBotfixed category names
7318view12:42, 4 November 2007MaintBotAdded categories to GPML
6406view22:18, 22 May 2007M.Liebermangpml file for [[Human:Wnt_signaling]]

External references


View all...
NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183
APCGeneProduct324 (Entrez Gene)
AXIN1GeneProduct8312 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CSNK1EGeneProduct1454 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
FBXW2GeneProduct26190 (Entrez Gene)
FOSL1GeneProduct8061 (Entrez Gene)
FRAT1GeneProduct10023 (Entrez Gene)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
JUNGeneProduct3725 (Entrez Gene)
LDLRGeneProduct3949 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
PAFAH1B1GeneProduct5048 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PPP2R5CGeneProduct5527 (Entrez Gene)
PPP2R5EGeneProduct5529 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCEGeneProduct5581 (Entrez Gene)
PRKCGGeneProduct5582 (Entrez Gene)
PRKCHGeneProduct5583 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PRKD1GeneProduct5587 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
TCF-1/LEFGeneProductHs.371279 (UniGene)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)

Annotated Interactions

No annotated interactions

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