Ethanol metabolism resulting in production of ROS by CYP2E1 (Homo sapiens)

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1PPSIsiRNASP600125ROSPKCζ siRNAPromoterARENucleusNFE2L2Protein kinase CDiallyl sulfideSP1MAP2K2CYP2E1MAP2K1MAFFU0126MAPK8ethanolMAFKCYP2E1acetaldehydeVitamin CMAFGstaurosporinePSP1CYP2E1NFE2L2Stressors converted by CYP2E12-Difluoromethoxy-2,2-difluoroaceticacidfluorideEnfluraneHalothaneSevoflurane6-hydroxychlorzoxazoneisofluraneNAPQImethoxyfluraneacetaminophenchlorzoxazonetrifluoroacetic acidSubstrateOutcome metabolitefluoridefluoride


Description

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106788view13:26, 17 September 2019MaintBotHMDB identifier normalization
104897view15:37, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98054view06:02, 13 July 2018Fehrhartfixed greek character
98053view06:00, 13 July 2018Fehrhartlayout
97869view12:01, 12 June 2018Marvin M2Modified description
97427view14:26, 16 May 2018AdoBioInfoHomo sapiens pathway was missing the list with substrates, woops.
97426view14:21, 16 May 2018AdoBioInfoAdded a sweet elbow arrow to fix an unconnected line. And added a reference, because y'all love references.
97154view08:04, 2 May 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97142view11:56, 1 May 2018AdoBioInfoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-hydroxychlorzoxazoneMetaboliteHMDB60998 (HMDB)
CYP2E1GeneProductENSG00000130649 (Ensembl)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
EnfluraneMetaboliteHMDB14373 (HMDB)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
MAFFGeneProductENSG00000185022 (Ensembl)
MAFGGeneProductENSG00000197063 (Ensembl)
MAFKGeneProductENSG00000198517 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
NAPQIMetaboliteCHEBI:29132 (ChEBI)
NFE2L2GeneProductENSG00000116044 (Ensembl)
Protein kinase CProteinA0A087X0I9 (Uniprot-TrEMBL)
SP1GeneProductENSG00000185591 (Ensembl)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
U0126MetaboliteCHEBI:64208 (ChEBI)
Vitamin CMetaboliteCHEBI:38290 (ChEBI)
acetaldehydeMetaboliteCHEBI:15343 (ChEBI)
acetaminophenMetaboliteCHEBI:46195 (ChEBI)
chlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
ethanolMetaboliteCHEBI:16236 (ChEBI)
fluorideMetaboliteCHEBI:17051 (ChEBI)
isofluraneMetaboliteCHEBI:6015 (ChEBI)
methoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
staurosporineMetaboliteCHEBI:57491 (ChEBI)
trifluoroacetic acidMetaboliteCHEBI:45892 (ChEBI)

Annotated Interactions

No annotated interactions

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