Ethanol metabolism resulting in production of ROS by CYP2E1 (Homo sapiens)

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PPSIPromoterAREsiRNASP600125ROSNucleusPKCζ siRNAMAFKacetaldehydeNFE2L2ethanolSP1MAFFU0126Protein kinase CDiallyl sulfideCYP2E1Vitamin CstaurosporineMAP2K2MAP2K1MAPK8MAFGCYP2E1PSP1CYP2E1NFE2L2


Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes.

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Ontology Terms



  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC


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106788view13:26, 17 September 2019MaintBotHMDB identifier normalization
104897view15:37, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98054view06:02, 13 July 2018Fehrhartfixed greek character
98053view06:00, 13 July 2018Fehrhartlayout
97869view12:01, 12 June 2018Marvin M2Modified description
97427view14:26, 16 May 2018AdoBioInfoHomo sapiens pathway was missing the list with substrates, woops.
97426view14:21, 16 May 2018AdoBioInfoAdded a sweet elbow arrow to fix an unconnected line. And added a reference, because y'all love references.
97154view08:04, 2 May 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97142view11:56, 1 May 2018AdoBioInfoNew pathway

External references


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NameTypeDatabase referenceComment
CYP2E1GeneProductENSG00000130649 (Ensembl)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
MAFFGeneProductENSG00000185022 (Ensembl)
MAFGGeneProductENSG00000197063 (Ensembl)
MAFKGeneProductENSG00000198517 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
Protein kinase CProteinA0A087X0I9 (Uniprot-TrEMBL)
SP1GeneProductENSG00000185591 (Ensembl)
U0126MetaboliteCHEBI:64208 (ChEBI)
Vitamin CMetaboliteCHEBI:38290 (ChEBI)
acetaldehydeMetaboliteCHEBI:15343 (ChEBI)
ethanolMetaboliteCHEBI:16236 (ChEBI)
staurosporineMetaboliteCHEBI:57491 (ChEBI)

Annotated Interactions

No annotated interactions

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