Ethanol metabolism resulting in production of ROS by CYP2E1 (Rattus norvegicus)

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1NucleusSP600125PromotersiRNA2-Difluoromethoxy-2,2-difluoroacetic acidStressors converted by CYP2E1PPSIROSAREPKCζ siRNAMafkMaffSevofluraneMap2k2EthanolHalothaneacetaldehydeTrifluoroacetic acidAcetaminophenNfe2l26-HydroxychlorzoxazoneVitamin CIsofluraneFluorideCyp2e1NAPQIMapk8ChlorzoxazoneU0126Protein kinase CMap2k1EnfluraneSp1MethoxyfluraneMafgDiallyl sulfideStaurosporinePSp1Nfe2l2SubstrateOutcome metaboliteFluorideFluorideCyp2e1Cyp2e1


Description

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for human and mouse.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106992view13:45, 17 September 2019MaintBotHMDB identifier normalization
104896view15:37, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98052view05:54, 13 July 2018Fehrhartlayout
98051view05:52, 13 July 2018Fehrhartsome layout work
97871view12:02, 12 June 2018Marvin M2Modified description
97141view11:53, 1 May 2018AdoBioInfoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
6-HydroxychlorzoxazoneMetaboliteHMDB60998 (HMDB)
AcetaminophenMetaboliteCHEBI:46195 (ChEBI)
ChlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
Cyp2e1GeneProductENSRNOG00000012458 (Ensembl)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
EnfluraneMetaboliteHMDB14373 (HMDB)
EthanolMetaboliteCHEBI:16236 (ChEBI)
FluorideMetaboliteCHEBI:17051 (ChEBI)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
IsofluraneMetaboliteCHEBI:6015 (ChEBI)
MaffGeneProductENSRNOG00000012886 (Ensembl)
MafgGeneProductENSRNOG00000036697 (Ensembl)
MafkGeneProductENSRNOG00000001277 (Ensembl)
Map2k1GeneProductENSRNOG00000010176 (Ensembl)
Map2k2GeneProductENSRNOG00000020005 (Ensembl)
Mapk8GeneProductENSRNOG00000020155 (Ensembl)
MethoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
NAPQIMetaboliteCHEBI:29132 (ChEBI)
Nfe2l2GeneProductENSRNOG00000001548 (Ensembl)
Protein kinase CProteinA0A0G2K5Q0 (Uniprot-TrEMBL)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
Sp1GeneProductENSRNOG00000014084 (Ensembl)
StaurosporineMetaboliteCHEBI:57491 (ChEBI)
Trifluoroacetic acidMetaboliteCHEBI:45892 (ChEBI)
U0126MetaboliteCHEBI:64208 (ChEBI)
Vitamin CMetaboliteCHEBI:38290 (ChEBI)
acetaldehydeMetaboliteCHEBI:15343 (ChEBI)

Annotated Interactions

No annotated interactions

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